Heck's disease: a diagnostic challenge

Turco, Martina; Magnaterra, Elisabetta; Bisanzi, Simonette; Cannistrà, Stefania; Paganini, Irene; Sani, Cristina; Pisano, L

doi:10.1111/ijd.16430

Cited by 1 publication

(2 citation statements)

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“…Agnew C et al reported a 5-year-old girl presented with papulonodular lesions on the labial mucosa, along with papillomatous nodules on the gingiva and tongue in 2017 [ 19 ]. The latest two gingiva-involved MEH cases were reported in 2023: Turco M et al described soft pedunculated papules located on the buccal mucosa, hard palate and oral commissures of a 12‐year‐old Peruvian girl, and revealed the presence of HPV-32 [ 20 ]. Santana-Gutierrez A et al present successful treatment of MEH on gingival, buccal mucosa and lips of a 14-year-old girl with intralesional immunotherapy [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…All lesions spontaneously resolved after 15 months Betz. SJ et al (2019) [ 5 ] A clinical image of generalized MEH lesions across the gingival of both arches was illustrated in the review without detailed information Turco M et al (2023) [ 20 ] 12, F buccal mucosa, hard palate, and oral commissures multiple exophytic papules of different sizes, having the same color as the surrounding epithelium HPV 32. PCR Not mentioned Santana-Gutierrez A et al (2023) [ 21 ] 14, F gingival, buccal mucosa, lips and tongue multiple mucosal-colored, soft papules Not mentioned Intralesional immunotherapy with MMR vaccine, combined with the application of TCA.…”

Section: Discussionmentioning

confidence: 99%

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Multifocal epithelial hyperplasia confined to the interdental papilla of an adult Chinese man: a rare case report and literature review

Wang,

Xu,

et al. 2023

BMC Oral Health

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Background Multifocal epithelial hyperplasia (MEH), or focal epithelial hypertension (FEH), or Heck’s disease, is an uncommon, benign oral mucosal disease associated with human papillomavirus infection. It is mostly observed in indigenous populations of the world, and has been rarely reported in China. However, previous research suggested there might be a greater prevalence of MEH in the Chinese population. While predominantly involves the lips, buccal mucosa and tongue, MEH was occasionally reported to affect the hard palate and gingiva as well. Case presentation This paper reports a case of extensive MEH lesions that confined to the interdental papilla of a Chinese male without detection of HPV, and summarizes the published gingiva-involved MEH reports from 1966 until present. The lesions were excised with an Er: YAG laser after scaling and root planning, no recurrence was observed after 6-month follow-up. Conclusions The present report illustrates the need for clinicians to be aware of rare presentations of MEH to facilitate a prompt diagnosis and proper management. More reports are encouraged to determine a correct prevalence rate of MEH in China.

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Section: Discussionmentioning

confidence: 99%