Hedgehog pathway signaling in cervical carcinoma and outcome after chemoradiation

Chaudary, Naz; Pintilie, Melania; Hedley, David W.; Fyles, Anthony; Milosevic, Michael; Clarke, Blaise A.; Hill, Richard P.; Mackay, Helen

doi:10.1002/cncr.26635

Cited by 52 publications

(47 citation statements)

References 38 publications

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“…The expression of SMO mRNA is enhanced in the tumor nests of the nodular basal cell carcinoma (BCC), especially at the advancing portions, but is under the detectable level in the superficial BCC cases examined, indicating that smo mRNA expression might be associated with BCC tumor progression (Tojo et al,1999). Aberrant expression SMO is common in human pancreatic carcinoma tissues and is associated with the low-level differentiation of tumor tissue, which indicat that SMO plays a fundamental role in pancreas tumorigenesis (Shao et al, 2006).The risk of local recurrence of cervical carcinoma after chemoradiation is also associated with the up-regulation of SMO (Chaudary et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Expression of Smoothened Protein in Colon Cancer and its Prognostic Value for Postoperative Liver Metastasis

Ding

Wang²,

Zhao³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Asian Pacific J Cancer Prev, 13, 4001-4005 IntroductionColon cancer is one of the most common cancers in the world and has a high propensity for liver metastasis (Ochiai et al., 2008;Jemal et al., 2010;Yassin et al., 2010;Soydinc et al., 2011). The major cause of death from colon cancer is liver metastasis, which is usually resistant to conventional therapies (Fidler, 1990). 35%-55% of patients with colon cancer will develop liver metastases during the course of illness. Survival following hepatic resection of colorectal metastasis now approaches 35%-50%. However, the recurrence rate in 5 years is as high as approximately 65% (Mayo and Pawlik, 2009). Early treatment targeting colon cancer liver metastatic foci might be important for improving patient survival. To date, the precise mechanisms leading to liver metastasis in colon cancer remains unknown, and biomarkers for liver metastasis are still lacking.The hedgehog (Hh) signaling pathway is known to play essential roles in multiple aspects of embryonic development. Hh protein binds to its receptor human patched 1 homologue (PTCH1), and relieves PTCH1's inhibition on smoothened (SMO), allowing SMO to signal downstream to glioma-associated oncogene homolog (Gli) transcriptional factors, which activates the target genes

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Section: Discussionmentioning

confidence: 99%

Expression of Smoothened Protein in Colon Cancer and its Prognostic Value for Postoperative Liver Metastasis

Ding

Wang²,

Zhao³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Later, it was shown that overexpression of DVL-1, an upstream regulator that prevents sequestration of β-catenin, resulted in constitutively active Wnt signaling and promoted tumorigenesis (Okino et al 2003). High nuclear expression of GLI, the downstream mediator of Hh, and other components of this pathway are overexpressed in cervical cancer and have been implicated in tumor recurrence (Xuan et al 2006;Chaudary et al 2012). These studies represent individual contribution of signaling pathways in cervical cancer.…”

Section: Stem Cell Signaling In Cervical Cancermentioning

confidence: 95%

Cervical Cancer Stem Cells and Their Association with Human Papillomavirus: Are They Ready as Anticancer Targets?

Vishnoi

Tyagi

Singh

et al. 2014

Multi-Targeted Approach to Treatment of Cancer

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Despite well-established human papillomavirus (HPV)-mediated etiology of cervical cancer, it has remained a major cause of cancer-related mortality of women from developing countries. Factors that contribute to high mortality rate primarily include disease diagnosis in advanced stages and failure of conventional treatment offered to these patients resulting in tumor relapse. Cancer stem cells (CSCs), in spite of controversies on their existence, are emerging as important players that initiate and maintain the tumor phenotype, govern tumor relapse, and chemo-/radioresistance, and thus considered as main factor that decides the treatment outcome. Recent studies provide evidence not only for presence of CSCs but

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“…For example, Hedgehog signaling pathway has been reported to be associated with small-cell lung cancer, pancreatic adenocarcinoma, and prostate cancer [38][39][40]. Hedgehog genes are detected in most cervical cancers, and the Hedgehog pathway plays a critical role in repopulation following chemoradiation [41]. Therefore, these genes are likely to be involved in the development and progression of cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Identifying Molecular Markers of Cervical Cancer Based on Competing Endogenous RNA Network Analysis

Qin

Gao

Yang

et al. 2019

Gynecol Obstet Invest

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Aim: Recurrence being a major challenge for the treatment of cervical cancer, we aimed at identifying novel molecular markers of cervical cancer to improve recurrence prediction. Methods: Cervical cancer samples were obtained from the Cancer Genome Atlas. Prognosis-associated long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs between recurrent and nonrecurrent samples were acquired using expression analysis. Regulatory relationships among these prognosis-associated RNAs were predicted and used to construct a competing endogenous RNA (ceRNA) network. Key prognostic lncRNAs, miRNAs, and mRNAs were identified using the ceRNA network, followed by the Kaplan-Meier survival analysis to reveal the influence of these key prognostic RNAs on prognosis. Results: In total, 15 lncRNAs, 10 miRNAs, and 348 mRNAs were identified as significant prognosis-associated molecules. The cervical cancer-related ceRNA network contained 13 prognosis-associated lncRNAs, 5 prognosis-associated miRNAs, and 120 prognosis-associated mRNAs. Key prognostic lncRNAs, miRNAs, and mRNAs were further identified using the ceRNA network. The key prognostic lncRNAs included H19 and HOTAIR, those for miRNAs included hsa-miR-133b, hsa-miR-138, and hsa-miR-301b, and those for mRNAs included Wnt family member 2, fibroblast growth factor 7, fibronectin 1, synaptic vesicle glycoprotein 2A, and bone morphogenetic protein 7. Conclusion: The key prognostic lncRNAs, miRNAs, and mRNAs may serve as potential molecular markers for recurrence prediction and may contribute to the treatment of cervical cancer.

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Hedgehog pathway signaling in cervical carcinoma and outcome after chemoradiation

Cited by 52 publications

References 38 publications

Expression of Smoothened Protein in Colon Cancer and its Prognostic Value for Postoperative Liver Metastasis

Expression of Smoothened Protein in Colon Cancer and its Prognostic Value for Postoperative Liver Metastasis

Cervical Cancer Stem Cells and Their Association with Human Papillomavirus: Are They Ready as Anticancer Targets?

Identifying Molecular Markers of Cervical Cancer Based on Competing Endogenous RNA Network Analysis

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