Height and blood chemistry in adults with a history of developmental arsenic poisoning from contaminated milk powder

Yorifuji, Takashi; Matsuoka, Kenichi; Grandjean, Philippe

doi:10.1016/j.envres.2017.02.002

Cited by 3 publications

(3 citation statements)

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“…In addition, osteoresorptive arsenic intoxication (ORAI) is related to bone metabolism in patients chronically exposed to iAs [2]. The elevated ALP activity observed in the patient has been described in several epidemiological studies of CAsI [19][20][21] and it is probably caused by the competitive inhibition of phosphatases by arsenic [22][23][24]. In an experiment with growing and finishing pigs, high dietary arsenic elevated the activities of ALP, GGT, GPT, and decreased total protein, urea nitrogen, creatinine, triglycerides and average daily gain, as well as increasing feed gain ratio and the retention of copper, iron and zinc in the viscera [25].…”

Section: Discussionmentioning

confidence: 99%

A curious association of chronic homeopathic arsenic ingestion with nonspecific symptoms in a Swiss teenager

Dani¹

2019

Swiss Med Wkly

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Arsenic is a toxicant that has no dose threshold below which exposures are not harmful. Here I report a curious association of chronic homeopathic arsenic ingestion with nonspecific symptoms in a Swiss teenager. For about 4 years she had taken globules of a freely purchasable homeopathic remedy containing inorganic arsenic (iAs), infinitesimally diluted to D6 (average arsenic content per single globule: 0.85 ± 0.08 ng). In the previous 7 months she had taken 20 to 50 globules daily (average 30 ng arsenic daily). She complained of nausea, stomach and abdominal cramps, diarrhoea and flatulence, headache, dizziness, anxiety, difficulty concentrating, insomnia, snoring, leg cramps and fatigue, loss of appetite, increased thirst and sweating, reduced diuresis, weight gain, paleness and coolness of both hands with a furry feeling of the hands, eczema of the hands, arms and legs, conjunctivitis and irregular menstruation. The physical and laboratory examinations showed a body mass index of 30 kg/ m 2 , acne vulgaris, bilateral spotted leukonychia, eczema of hands, arms and legs, non-pitting oedema of the legs, elevated plasma alkaline phosphatase activity, folate deficiency and severe vitamin D3 insufficiency. The arsenic concentration in her blood was <0.013 µmol/l, and arsenic was undetectable in her scalp hair. The total iAs concentration was 116 nmol/l in the morning urine and 47 nmol/l in the afternoon urine. The urinary arsenic concentration decreased and the patient's complaints improved upon interruption of the arsenic globules, vitamin D3, thiamine and folic acid supplementation, and symptomatic therapy. It is concluded that an avoidable toxicant such as inorganic arsenic, for which no scientific safe dose threshold exists, should be avoided and not be found in over-the-counter medications.

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Section: Discussionmentioning

confidence: 99%

A curious association of chronic homeopathic arsenic ingestion with nonspecific symptoms in a Swiss teenager

Dani¹

2019

Swiss Med Wkly

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“…bifunctional monomer As(III)-ion-imprinted polymer, and the fitting results were analyzed to explore the adsorption process of the imprinted and non-imprinted polymers. The equation for the Langmuir isotherm adsorption model is shown in eqn (7), and the equation for the Freundlich isotherm adsorption model is shown in eqn (9).…”

Section: Adsorption Isotherms and Kinetics Studiesmentioning

confidence: 99%

“…7 This is because As( iii ) can combine with the sulfhydryl groups of more than 200 proteins in the human body, thus inhibiting the activity of these sulfhydryl-group-containing proteins. 8 Trace amounts of As( iii ) can inhibit the formation of red blood cells in humans, and short-term exposure to As( iii ) can cause diarrhea, vomiting and skin cancer, 9 while long-term exposure to As( iii ) can cause diseases of the human nervous system, reproductive system and cardiovascular system. 10 As early as 2008, the World Health Organization (WHO) changed the maximum allowable concentration of As( iii ) in drinking water from 50 μg L −1 to 10 μg L −1 .…”

Section: Introductionmentioning

confidence: 99%