Height in relation to dementia death: individual participant meta-analysis of 18 UK prospective cohort studies

Russ, Tom C.; Kivimäki, Mika; Starr, John M.; Stamatakis, Emmanuel; Batty, G. David

doi:10.1192/bjp.bp.113.142984

Cited by 51 publications

(45 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There has been widespread interest in the association between height and cognitive ability from the development of preterm infants (Sammallahti et al 2014) to aging-related dementia (Russ et al 2014). Height is highly heritable, but is also considered to reflect early life events and is often regarded as a proxy for early brain development.…”

Section: Introductionmentioning

confidence: 99%

Brain structure mediates the association between height and cognitive ability

Vuoksimaa

Panizzon

Franz

et al. 2017

Preprint

View full text Add to dashboard Cite

Height and general cognitive ability are positively associated, but the underlying mechanisms of this relationship are not well understood. Both height and general cognitive ability are positively associated with brain size. Still, the neural substrate of the height-cognitive ability association is unclear. We used a sample of 515 middle-aged male twins with structural magnetic resonance imaging data to investigate whether the association between height and cognitive ability is mediated by cortical size. In addition to cortical volume, we used genetically, ontogenetically and phylogenetically distinct cortical metrics of total cortical surface area and mean cortical thickness. Height was positively associated with general cognitive ability and total cortical volume and cortical surface area, but not with mean cortical thickness. Mediation models indicated that the wellreplicated height-general cognitive ability association is accounted for by individual differences in total cortical volume and cortical surface area (highly heritable metrics related to global brain size), and that the genetic association between cortical surface area and general cognitive ability underlies the phenotypic height-general cognitive ability relationship.

show abstract

Section: Introductionmentioning

confidence: 99%

Brain structure mediates the association between height and cognitive ability

Vuoksimaa

Panizzon

Franz

et al. 2017

Preprint

View full text Add to dashboard Cite

show abstract

“…In the absence of studies with follow-up encompassing entire life-spans, identifying exposures which capture experiences from different stages of life are important in the investigation of life course effects on disease. For example, height—regarded as a marker of early life illness, adversity, nutrition or psychosocial stress9—has been shown to be associated with dementia 10. Pulmonary function is also affected by multiple factors throughout the life course, not merely in early life, notably smoking, and it has been suggested that decreased lung function is linked to both cardiovascular disease11 12 and cognitive decline,13–19 as well as to overall mortality 12 20 21.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary function as a risk factor for dementia death: an individual participant meta-analysis of six UK general population cohort studies

Russ

Starr

Stamatakis

et al. 2015

J Epidemiol Community Health

Self Cite

View full text Add to dashboard Cite

show abstract

“…Combined with a unique personal identification number, it is possible to link health examination surveys and other registries to investigate the association between a range of possible dementia-related risk factors, such as smoking, physical inactivity, hypertension and elevated cholesterol level, and dementia-related mortality. Observational studies have previously used dementia-related mortality as a proxy for clinical dementia diagnosis [15,16,17,18,19,20,21,22], but we are unaware of any case-control studies, or observational studies, that have used dementia-related mortality in combination with ApoE genotypes. There were two aims of our study.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Apolipoprotein E Genotypes, Lifestyle Factors and Future Risk of Dementia-Related Mortality: The Cohort of Norway (CONOR)

Strand

Rosness²,

Engedal³

et al. 2015

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background/Aims: Our aims were two-fold: firstly, to investigate the association and interaction between apolipoprotein E (ApoE), lifestyle risk factors and dementia-related mortality and, secondly, to examine if using dementia-related mortality yielded comparable risk estimates for the ApoE genotypes as reported in studies using a clinical dementia diagnosis as the end point. Methods: We used a nested case-control study with 561 cases drawn from dementia deaths in the Cohort of Norway (CONOR) and 584 alive controls. Results: ApoE ε4 carriers were at increased risk of dementia-related mortality compared to noncarriers [odds ratio (OR) 2.46, 95% confidence interval (CI) 1.93-3.13], and ε4 homozygotes were at particularly high risk (OR 7.86, 95% CI 3.80-13.8), while the ε2 type was associated with a lower risk. The highest risk of dementia-related mortality was found among ε4 carriers with more lifestyle risk factors (ε4 carriers who were smokers, hypertensive, physically inactive and diabetics) versus ε4 noncarriers without lifestyle risk factors (OR 15.4, 95% CI 4.37-52.4). The increased risk was additive, not multiplicative. Conclusions: Ensuring a healthy lifestyle is important to be able to prevent dementia in populations at large, but especially for ε4 carriers. Using dementia mortality gives comparable results for the ApoE-dementia association as studies using clinical dementia diagnoses.

show abstract

Height in relation to dementia death: individual participant meta-analysis of 18 UK prospective cohort studies

Abstract: Early-life circumstances, indexed by adult height, may influence later dementia risk.

Cited by 51 publications

References 41 publications

Brain structure mediates the association between height and cognitive ability

Brain structure mediates the association between height and cognitive ability

Pulmonary function as a risk factor for dementia death: an individual participant meta-analysis of six UK general population cohort studies

Interaction of Apolipoprotein E Genotypes, Lifestyle Factors and Future Risk of Dementia-Related Mortality: The Cohort of Norway (CONOR)

Contact Info

Product

Resources

About