Heilpflanzenporträt: Strophanthus

Shah, Yatin

doi:10.1055/s-0030-1270925

Cited by 1 publication

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“…The traditional uses of Strophanthus seeds in heart conditions were presumably peroral [8][9][10]. Although the general (particularly the oral) use of Strophanthus preparations is currently marginalized by academic medicine [15,44,45], some scientific reports and papers describe the advantages of this therapy based on medical experience and practice [13,15,17,18,46]. In the past, the Strophanthus tincture (that, as demonstrated here, should contain saponins) was found to be more effective than isolated ouabain in an oral application [5].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, some pharmaceutical companies still supply pure ouabain and other Strophanthus glycosides. A homeopathic mother tincture from S. gratus seeds (Q, D1; drug-to-solvent ratio (DSR) 1 : 10) and its equivalent on-prescription preparations (to be made in pharmacies) are available and recommended for oral use under medical supervision in Germany [15,17]. Moreover, Strophanthus seeds are easily available via the Internet, often accompanied by tips on preparing them as homemade medicines [15,18] of unknown efficacy and toxicity.…”

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confidence: 99%

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An in-depth look into a well-known herbal drug: Fingerprinting, isolation, identification, and content estimation of saponins in different Strophanthus seeds

Włodarczyk

Gleńsk

2021

Planta Med

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Seeds of Strophanthus species are known as a source of rapid-acting cardenolides. These water-soluble glycosides are listed as the sole critical constituents of this raw herbal drug. A non-standard cardioprotective medication with ouabain-containing oral remedies has become popular in Europe as a result of the withdrawal of corresponding registered drugs from the market. However, the bioequivalence of pure ouabain solutions, tinctures, and home-made extracts from Strophanthus seeds is unknown. Thus, this study aimed to update the information on the composition of Strophanthus seeds used for this purpose. The distribution of two main saponins and about 90 previously unreported compounds, tentatively identified as saponins in eleven Strophanthus species, was systematically evaluated by ultra-high-performance liquid chromatography mass spectrometry (UHPLC-MS) and -MS/MS. Seeds of S. gratus were selected to isolate the dominant unreported triterpenoids, bidesmosides of echinocystic and oleanolic acid. Their structures were established by HRMS, MS/MS, as well as by NMR techniques. The total saponin content, estimated by UHPLC-MS, was up to 1%. The detected saponins could influence the peroral bioavailability of hardly absorbable Strophanthus cardenolides and exhibit their own activity. This finding may be relevant when Strophanthus preparations (containing both saponins and cardiac glycosides) are used, particularly when homemade preparations are administered.

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