ABSTRACT. The purpose of this study was to compare between the injection speed and iodine delivery rate in order to establish a concept for reproducible contrast timing in contrast-enhanced computed tomography (CT) for small animals. Clinically healthy beagle dogs were administered a nonionic iodinate contrast medium at a dose of 800 mgI/kg; they were divided into 3 groups (n=5, crossover method): in one group, the injection speed was fixed at 1.0 ml/sec, and in the second and third groups, the iodine delivery rate was fixed (the injection durations were 30 and 60 sec, respectively). The variation in scatter of the time to aortic and hepatic peak enhancement in the fixed iodine delivery groups was lower than that in the fixed injection speed group. These results suggest that in contrast-enhanced CT for small animals, the contrast medium should be injected at a fixed iodine delivery rate in order to provide reproducible contrast timing. KEY WORDS: canine, contrast medium, CT, injection speed, iodine delivery rate.J. Vet. Med. Sci. 70(10): 1027-1030, 2008 Computed tomography (CT) was first introduced in veterinary medicine in the 1980s [3]. The performance of CT improved thereafter, with a shorter scan time and better imaging quality, and CT is now one of the most valuable diagnostic tools, especially for oncological diseases [7]. In abdominal CT, contrast examination is quite important, since it differentiates between abnormal masses and normal tissue by indicating blood flow or vascular permeability, thereby providing diagnostic information. In human medicine, contrast studies with abdominal CT are considered useful in more than 95% cases for the diagnosis of mass lesions [6].The iodine concentration decreases soon after injection of intravenous contrast medium, because it is diluted in the vessels, distributed in the entire body, and excreted from the kidneys. Thus, the contrast effect is influenced by the time of scanning in that an optimal scan timing provides the greatest contrast enhancement. While a detailed contrastenhanced CT protocol is well established in human medicine, there are very few standards for the contrast enhancement protocol in small animals. The injection speed (in terms of ml/sec) is often standardized, but the iodine delivery rate is rarely set. Different volumes of contrast medium may alter the injection duration, and it may be difficult to set an appropriate scan timing. This study focused on the injection speed and iodine delivery rate in the case of normal beagles in order to establish a concept for reproducible contrast timing in contrast-enhanced CT for small animals.
MATERIALS AND METHODSFive clinically healthy beagle dogs (3-5 years old, 8.9-15.4 kg) were used in a crossover method, and the experiments were performed following the guidelines of the institutional policies for veterinary clinical investigations. The animals were starved for 12 hr before the CT study. A physical examination was conducted, and the complete blood count and serum chemistry profile (blood urea nitrogen,...