Helical flow as fluid dynamic signature for atherogenesis risk in aortocoronary bypass. A numeric study

Morbiducci, Umberto; Ponzini, Raffaele; Grigioni, Mauro; Redaelli, Alberto

doi:10.1016/j.jbiomech.2006.02.017

Cited by 163 publications

(151 citation statements)

References 58 publications

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“…The swirl inducer inherently creates helical flow which is established in the literature to constitutes an important flow signature in vessels. 29 In fact, recent literature has indicated that helical flow in the aortic arch, originated by its complex curvature amongst other complex anatomical traits, 9,19 plays a key role in promoting physiologically advantageous phenomena such as improved vascular washout and relatively uniform WSS distributions 28 as well as avoidance of turbulence development. 30 Given that aortic arches cannulated using today's state-of-the-art end-hole type cannulae are associated with a highly non-physiological flow fields, the design of outflow tips which facilitate physiologic helical aortic flows is of the essence.…”

Section: The Swirl Inducer Designmentioning

confidence: 99%

Aortic Outflow Cannula Tip Design and Orientation Impacts Cerebral Perfusion During Pediatric Cardiopulmonary Bypass Procedures

et al. 2013

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Abstract-Poor perfusion of the aortic arch is a suspected cause for peri-and post-operative neurological complications associated with cardiopulmonary bypass (CPB). High-speed jets from 8 to 10FR pediatric/neonatal cannulae delivering 1 L/min of blood can accrue sub-lethal hemolytic damage while also subjecting the aorta to non-physiologic flow conditions that compromise cerebral perfusion. Therefore, we emphasize the importance of cannulation strategy and hypothesize engineering better CPB perfusion through a redesigned aortic cannula tip. This study employs computational fluid dynamics to investigate novel diffuser-tipped aortic cannulae for shape sensitivity to cerebral perfusion, in an in silico cross-clamped aortic arch model modeled with fixed outflow resistances. 17 parametrically altered configurations of an 8FR end-hole and several diffuser cone angled tips in combination with jet incidence angles toward or away from the head-neck vessels were studied. Experimental pressure-flow characterizations were also conducted on these cannula tip designs. An 8FR end-hole aortic cannula delivering 1 L/min along the transverse aortic arch was found to give rise to backflow from the brachicephalic artery (BCA), irrespective of angular orientation, for the chosen ascending aortic insertion location. Parametric alteration of the cannula tip to include a diffuser cone angle (tested up to 7°) eliminated BCA backflow for any tested angle of jet incidence. Experiments revealed that a 1 cm long 10°diffuser cone tip demonstrated the best pressure-flow performance improvement in contrast with either an end-hole tip or diffuser cone angles greater than 10°. Performance further improved when the diffuser was preceded by an expanded four-lobe swirl inducer attachment-a novel component. In conclusion, aortic cannula orientation is crucial in determining net head-neck perfusion but precise angulations and insertion-depths are difficult to achieve practically. Altering the cannula tip to include a diffuser cone angle has been shown for the first time to have potential in ensuring a net positive outflow at the BCA. Cannula insertion distanced from the BCA inlet may also avoid backflow owing to the Venturi effect, but the diffuser tipped cannula design presents a promising solution to mitigate this issue irrespective of in vivo cannula tip orientation.

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Section: The Swirl Inducer Designmentioning

confidence: 99%

Aortic Outflow Cannula Tip Design and Orientation Impacts Cerebral Perfusion During Pediatric Cardiopulmonary Bypass Procedures

et al. 2013

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“…It may be interesting to note that the linear or curvilinear translation of a vortex results in a spiral flow known as a helix. 3,45,46 Circulation of Blood Through the Right Atrium and Ventricle…”

Section: Vorticity Analysis Of Right Atrial Flowmentioning

confidence: 99%

Cardiac Flow Analysis Applied to Phase Contrast Magnetic Resonance Imaging of the Heart

et al. 2009

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Abstract-Phase contrast magnetic resonance imaging is performed to produce flow fields of blood in the heart. The aim of this study is to demonstrate the state of change in swirling blood flow within cardiac chambers and to quantify it for clinical analysis. Velocity fields based on the projection of the three dimensional blood flow onto multiple planes are scanned. The flow patterns can be illustrated using streamlines and vector plots to show the blood dynamical behavior at every cardiac phase. Large-scale vortices can be observed in the heart chambers, and we have developed a technique for characterizing their locations and strength. From our results, we are able to acquire an indication of the changes in blood swirls over one cardiac cycle by using temporal vorticity fields of the cardiac flow. This can improve our understanding of blood dynamics within the heart that may have implications in blood circulation efficiency. The results presented in this paper can establish a set of reference data to compare with unusual flow patterns due to cardiac abnormalities. The calibration of other flow-imaging modalities can also be achieved using this well-established velocityencoding standard.

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“…The role of computational hemodynamics is fundamental to aid in the prognosis and diagnosis of cardiovascular diseases due the well-known correlation between the localization of these pathologies and hemodynamic quantities such as blood flow velocity, pressure, boundary layer separation and wall shear stress [4,6,7,11]. Among many types of approaches available in the field of computational hemodynamics and considering the potential clinical use of these models, the trade-off between quality of results and computational burden is a key aspect.…”

Section: Introductionmentioning

confidence: 99%

An efficient method for the numerical solution of blood flow in 3D bifurcated regions

Alvarez¹,

Blanco²,

Feijóo³

2018

Proceeding Series of the Brazilian Society of Computational and Applied Mathematics

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Abstract. From the point of view of the potential clinical use of computational hemodynamic, it is mandatory to get the computational time of simulation each time closer to real clinical needs. Spending hours and even days to solve accurately one single cardiac cycle of the whole cardiovascular system is unfeasible on daily practice. In this sense, in this work we study the transversally enriched pipe element method (TEPEM) as an effective alternative to solve the Navier-Stokes equations in bifurcated domains with enough accuracy to provide clinically relevant information but at a significantly reduced time.

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Helical flow as fluid dynamic signature for atherogenesis risk in aortocoronary bypass. A numeric study

Cited by 163 publications

References 58 publications

Aortic Outflow Cannula Tip Design and Orientation Impacts Cerebral Perfusion During Pediatric Cardiopulmonary Bypass Procedures

Aortic Outflow Cannula Tip Design and Orientation Impacts Cerebral Perfusion During Pediatric Cardiopulmonary Bypass Procedures

Cardiac Flow Analysis Applied to Phase Contrast Magnetic Resonance Imaging of the Heart

An efficient method for the numerical solution of blood flow in 3D bifurcated regions

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