trolled by the dimensions of the protein cavity and by the level of loading, which is itself a function of ion concentration, uptake specificity and reaction kinetics. One possibility that we are now investigating concerns the role of the functional groups on the protein cavity surface in dictating the nature of the inorganic reactions. For example, the products studied to date lack long-range structure whilst corresponding products formed in the absence of ferritin are often crystalline; this may be a reflection of the nucleation processes occurring at the protein surface. If this is so, then the use of site-directed mutagenesis may be a method of fine-tuning this supramolecular assembly for tailored inorganic materials synthesis.