Helical rosette nanotubes: A biomimetic coating for orthopedics?

Chun, Ai Lin; Moralez, Jesus G.; Webster, Thomas J.; Fenniri, Hicham

doi:10.1016/j.biomaterials.2005.05.080

Cited by 69 publications

(8 citation statements)

References 17 publications

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“…Furthermore, our scaffold is mainly composed of denatured collagen, and is thus better representative of the structural collagen matrix present in many soft tissues. Although we observed limited viability at the highest concentration of PEDOT:PSS that was tested, we believe efforts to neutralize charges on the PSS chain using self-assembled rosette nanotubes, for example, ,− will improve cell viability and mechanical stiffness.…”

Section: Resultsmentioning

confidence: 79%

Electroconductive Gelatin Methacryloyl-PEDOT:PSS Composite Hydrogels: Design, Synthesis, and Properties

Spencer

Primbetova

Koppes

et al. 2018

ACS Biomater. Sci. Eng.

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135

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Electroconductive hydrogels are used in a wide range of biomedical applications, including electrodes for patient monitoring and electrotherapy, or as biosensors and electrochemical actuators. Approaches to design electroconductive hydrogels are often met with low biocompatibility and biodegradability, limiting their potential applications as biomaterials. In this study, composite hydrogels were prepared from a conducting polymer complex, poly(3,4-ethylenedioxythiophene):polystyrenesulfonate (PEDOT:PSS) dispersed within a photo-crosslinkable naturally derived hydrogel, gelatin methacryloyl (GelMA). To determine the impact of PEDOT:PSS loading on physical and microstructural properties and cellular responses, the electrical and mechanical properties, electrical properties, and biocompatibility of hydrogels loaded with 0−0.3% (w/v) PEDOT:PSS were evaluated and compared to GelMA control. Our results indicated that the properties of the hydrogels, such as mechanics, degradation, and swelling, could be tuned by changing the concentration of PEDOT:PSS. In particular, the impedance of hydrogels decreased from 449.0 kOhm for control GelMA to 281.2 and 261.0 kOhm for hydrogels containing 0.1% (w/v) and 0.3% (w/v) PEDOT:PSS at 1 Hz frequency, respectively. In addition, an ex vivo experiment demonstrated that the threshold voltage to stimulate contraction in explanted abdominal tissue connected by the composite hydrogels decreased from 9.3 ± 1.2 V for GelMA to 6.7 ± 1.5 V and 4.0 ± 1.0 V for hydrogels containing 0.1% (w/v) and 0.3% (w/v) PEDOT:PSS, respectively. In vitro studies showed that composite hydrogels containing 0.1% (w/v) PEDOT:PSS supported the viability and spreading of C2C12 myoblasts, comparable to GelMA controls. These results indicate the potential of our composite hydrogel as an electroconductive biomaterial.

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Section: Resultsmentioning

confidence: 79%

Electroconductive Gelatin Methacryloyl-PEDOT:PSS Composite Hydrogels: Design, Synthesis, and Properties

Spencer

Primbetova

Koppes

et al. 2018

ACS Biomater. Sci. Eng.

Self Cite

135

View full text Add to dashboard Cite

show abstract

“…A major advantage of anodic oxidation is the ability to precisely control the diameter and shape of the nanotubular arrays to the desired scale, meeting the demands of a specific application by precisely controlling the anodization parameters. In a number of studies on the cell responses to TiO 2 nanotubes, nanosize effects have been shown for a variety of cells [8]–[11]. Park et al reported that vitality, proliferation, migration, and differentiation of MSCs and hematopoietic stem cells, as well as the behavior of osteoblasts and osteoclasts were strongly affected by the nanometric scale TiO 2 surface topography with a specific response to nanotube diameters between 15 and 100 nm [12].…”

Section: Introductionmentioning

confidence: 99%

Both Enhanced Biocompatibility and Antibacterial Activity in Ag-Decorated TiO2 Nanotubes

et al. 2013

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In this study, Ag is electron-beam evaporated to modify the topography of anodic TiO2 nanotubes of different diameters to obtain an implant with enhanced antibacterial activity and biocompatibility. We found that highly hydrophilic as-grown TiO2 nanotubes became poorly hydrophilic with Ag incorporation; however they could effectively recover their wettability to some extent under ultraviolet light irradiation. The results obtained from antibacterial tests suggested that the Ag-decorated TiO2 nanotubes could greatly inhibit the growth of Staphylococcus aureus. In vitro biocompatibility evaluation indicated that fibroblast cells exhibited an obvious diameter-dependent behavior on both as-grown and Ag-decorated TiO2 nanotubes. Most importantly, of all samples, the smallest diameter (25-nm-diameter) Ag-decorated nanotubes exhibited the most obvious biological activity in promoting adhesion and proliferation of human fibroblasts, and this activity could be attributed to the highly irregular topography on a nanometric scale of the Ag-decorated nanotube surface. These experimental results demonstrate that by properly controlling the structural parameters of Ag-decorated TiO2 nanotubes, an implant surface can be produced that enhances biocompatibility and simultaneously boosts antibacterial activity.

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“…A major advantage of anodic oxidation is the feasibility to well control the diameter and shape of the nanotubular arrays to the desired length scale, meeting the demands of a specific application by precisely controlling the anodization parameters. In a number of studies on the cell response to TiO 2 nanotubes, nanosize effects have been demonstrated for a variety of cells [16-18]. Park et al reported that vitality, proliferation, migration, and differentiation of MSCs and hematopoietic stem cells, as well as the behavior of osteoblasts and osteoclasts, are strongly influenced by the nanoscale TiO 2 surface topography with a specific response to nanotube diameters between 15 and 100 nm [19].…”

Section: Introductionmentioning

confidence: 99%

Diameter-sensitive biocompatibility of anodic TiO2 nanotubes treated with supercritical CO2 fluid

et al. 2013

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This work reports on the diameter-sensitive biocompatibility of anodic TiO2 nanotubes with different nanotube diameters grown by a self-ordering process and subsequently treated with supercritical CO2 (ScCO2) fluid. We find that highly hydrophilic as-grown TiO2 nanotubes become hydrophobic after the ScCO2 treatment but can effectively recover their surface wettability under UV light irradiation as a result of photo-oxidation of C-H functional groups formed on the nanotube surface. It is demonstrated that human fibroblast cells show more obvious diameter-specific behavior on the ScCO2-treated TiO2 nanotubes than on the as-grown ones in the range of diameters of 15 to 100 nm. This result can be attributed to the removal of disordered Ti(OH)4 precipitates from the nanotube surface by the ScCO2 fluid, thus resulting in purer nanotube topography and stronger diameter dependence of cell activity. Furthermore, for the smallest diameter of 15 nm, ScCO2-treated TiO2 nanotubes reveal higher biocompatibility than the as-grown sample.

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Helical rosette nanotubes: A biomimetic coating for orthopedics?

Cited by 69 publications

References 17 publications

Electroconductive Gelatin Methacryloyl-PEDOT:PSS Composite Hydrogels: Design, Synthesis, and Properties

Electroconductive Gelatin Methacryloyl-PEDOT:PSS Composite Hydrogels: Design, Synthesis, and Properties

Both Enhanced Biocompatibility and Antibacterial Activity in Ag-Decorated TiO2 Nanotubes

Diameter-sensitive biocompatibility of anodic TiO2 nanotubes treated with supercritical CO2 fluid

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