Helicobacter cinaedi-infected aneurysm and vertebral osteomyelitis in an immunocompetent patient

Toyoshima, Hirokazu; Tanigawa, Motoaki; Ishiguro, Chiaki; Tanaka, Hiroyuki; Nakanishi, Yuki; Sakabe, Shigetoshi

doi:10.1016/j.idcr.2022.e01426

Cited by 3 publications

(4 citation statements)

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“…20 Other presentations of H. cinaedi infection have also been reported, including hepatic cyst infection, 22 and infected abdominal aortic aneurysm with vertebral osteomyelitis. 23…”

Section: Discussionmentioning

confidence: 99%

“…20 Other presentations of H. cinaedi infection have also been reported, including hepatic cyst infection, 22 and infected abdominal aortic aneurysm with vertebral osteomyelitis. 23 We searched the English literature for reports on H. cinaedi bacteremia in children under 18 years old using the keywords "Helicobacter cinaedi" or "Campylobacter cinaedi" and bacteremia (PubMed search engine; January 02, 2023). We found 102 results, 7 of which were relevant to the pediatric age group.…”

Section: Discussionmentioning

confidence: 99%

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Helicobacter cinaedi Bacteremia in Children: A Case Report and Literature Review

Oren,

Temper,

Michael-Gayego

et al. 2024

Pediatric Infectious Disease Journal

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Helicobacter cinaedi is known to cause invasive infections in immunocompromised adults. Here we report the first case of H. cinaedi bacteremia in a child with nephrotic syndrome. The patient presented with a mild transient febrile illness that resolved spontaneously. We discuss the diagnostic challenges associated with this case and the microbiologic approach, including genomic analysis. Furthermore, we review the current case together with all previous pediatric cases (n = 6). Notably, all cases involved neonates or otherwise immunocompromised individuals and were characterized by severe disease with complicated infections (eg, meningitis, cholangitis and arthritis). H. cinaedi bacteremia in children is associated with a wide spectrum of clinical presentations ranging from mild to life-threatening conditions. This bacterium may be difficult to diagnose and require specialized methods.

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“…20 Other presentations of H. cinaedi infection have also been reported, including hepatic cyst infection, 22 and infected abdominal aortic aneurysm with vertebral osteomyelitis. 23…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Helicobacter cinaedi Bacteremia in Children: A Case Report and Literature Review

Oren,

Temper,

Michael-Gayego

et al. 2024

Pediatric Infectious Disease Journal

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“…Of the 27 identified publications, the authors found 15 published reports of discitis or NVO attributable exclusively to F . nucleatum [ 5 - 8 ]. To our knowledge, this is the first with an IVC thrombus.…”

Section: Discussionmentioning

confidence: 99%

Isolated Fusobacterium nucleatum Growth in the Blood Culture of a Middle-Aged Man With Lumbar Discitis, Surrounding Psoas Abscesses, and an Inferior Vena Cava Thrombus

Bomphrey,

Hayden,

Plant

2024

Cureus

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Pyogenic spinal infections (PSI) have an incidence of 0.5-2.2 cases per 100,000 population, though diagnosis can be delayed by up to three months. The incidence of Fusobacterium nucleatum bacteremia is rare, occurring in 0.22-0.34 cases per 100,000 population, whilst its implication in spinal infections is rarer still. A man in his 60s with a background of chronic lower back pain presented to the emergency department with a two-week history of worsening back pain associated with fever and difficulty voiding. He was initially managed as pyelonephritis due to the recent history of urinary tract infection (UTI) with fever and flank pain. However, there were radiculopathy and bilateral pain on hip flexion with reduced power on the right side. The light-touch sensation was reduced over the right hallux and distal L4 dermatome. These neurological deficits associated with deranged infective markers made a diagnosis of discitis plausible. Discitis and native vertebral osteomyelitis (NVO) should be suspected in patients reporting a fever and back pain of recent onset or increasing in severity. Once discitis was confirmed, the patient was subsequently tested for tuberculosis (TB) using a T-SPOT, human immunodeficiency virus (HIV), hepatitis B virus, and hepatitis C virus, with no positive findings, but in the days following, blood cultures yielded F. nucleatum . Guided by knowing the natural reservoirs in the body, establishing the source of F. nucleatum could be achieved through head and neck imaging and investigating the gastrointestinal tract for malignant or inflammatory processes.

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“…Later, the bacterium was found in other patient groups, including women and children ( Vandamme et al, 1990 ; Skirrow et al, 1993 ). Currently, both cases of H. cinaedi infection against a background of immunodeficiencies ( Saito et al, 2022 ; Roupie et al, 2023 ) and in immunocompetent patients have been reported ( Akiyama et al, 2021 ; Toyoshima et al, 2022 ).…”

Section: Pathologies Associated With the Bacterium Helicoba...mentioning

confidence: 99%

Helicobacter cinaedi bacterium association with atherosclerosis and other diseases

Voronina,

Arapidi

2024

Front. Microbiol.

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Helicobacter is a genus of spiral-shaped Gram-negative enterohepatic bacteria whose members are capable of causing bacteremia in humans. One of the poorly studied members of this genus is the bacterium Helicobacter cinaedi. This microorganism was first isolated from human fecal samples in 1984. Although it was long considered to be associated with only immunocompromised patients, more evidence in recent years has implicated H. cinaedi in causing serious pathologies in immunocompetent populations. In addition, H. cinaedi is also reported to be associated with a few chronic or severe illnesses, such as atherosclerosis, which in turn can lead to the development of other cardiovascular pathologies: one of the leading causes of mortality worldwide. Helicobacter cinaedi often goes unnoticed in standard diagnostic methods due to its slow growth under microaerobic conditions. This often leads to significant underdetection and hence undermines the role of this bacterium in the pathogenesis of various diseases and the extent of its spread in humans. In this review, we have compiled information on pathologies associated with H. cinaedi, the occurrence of the bacterium in humans and animals, and the latest developments in diagnosing the bacterium and treating associated diseases.

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Helicobacter cinaedi-infected aneurysm and vertebral osteomyelitis in an immunocompetent patient

Cited by 3 publications

References 4 publications

Helicobacter cinaedi Bacteremia in Children: A Case Report and Literature Review

Helicobacter cinaedi Bacteremia in Children: A Case Report and Literature Review

Isolated Fusobacterium nucleatum Growth in the Blood Culture of a Middle-Aged Man With Lumbar Discitis, Surrounding Psoas Abscesses, and an Inferior Vena Cava Thrombus

Helicobacter cinaedi bacterium association with atherosclerosis and other diseases

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