Helicobacter heilmannii and gastric cancer

Morgner, Andrea; Bayerdörffer, Ekkehard; Meining, Alexander; Stolte, Manfred; Kroher, G.

doi:10.1016/s0140-6736(95)91364-5

Cited by 72 publications

(57 citation statements)

References 5 publications

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“…Since then, H. heilmannii s.l. infection has been reported in cases of peptic ulcer disease [19,24,39,50] , gastric carcinoma [50][51][52] , and gastric MALT lymphoma [21,50,53] . Infected patients may be asymptomatic or present dyspeptic symptoms, such as chronic epigastric pain, nausea, vomiting, heartburn, dysphagia, and post-prandial discomfort [11,19,50,54] .…”

Section: H Heilmannii Sl-associated Diseases In Humansmentioning

confidence: 99%

Helicobacter heilmannii sensu lato: An overview of the infection in humans

Bento-Miranda

Figueiredo

2014

WJG

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Helicobacter heilmannii sensu lato (H. heilmannii s.l.) is a group of gastric non-Helicobacter pylori Helicobacter species that are morphologically indistinguishable from each other. H. heilmannii s.l. infect the stomach of several animals and may have zoonotic potential. Although the prevalence of these infections in humans is low, they are associated with gastric pathology, including mucosa-associated lymphoid tissue lymphoma, making them a significant health issue. Here, the taxonomy, epidemiology, microbiology, diagnosis, and treatment of these infections will be reviewed. The gastric pathology associated with H. heilmannii s.l. infections in humans will also be addressed. Finally, the features of the complete bacterial genomes available and studies on species-specific pathogenesis will be reviewed. The understanding of the mechanisms that underlie gastric disease development mediated by the different bacterial species that constitute H. heilmannii s.l. is essential for developing strategies for prevention and treatment of these infections. Core tip: Helicobacter heilmannii sensu lato is a group of non-Helicobacter pylori Helicobacter species that infect the stomach of animals and humans. In the human stomach, these infections are associated with several pathologies, but it is currently unknown whether certain species are more often associated with a certain disease outcome than others. The access to bacterial genomes together with the availability of increasing numbers of in vitro isolates will allow significant advances in the understanding of species-specific bacteria-host interactions in disease pathogenesis and will be essential for future development of strategies to prevent and treat these infections.

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Section: H Heilmannii Sl-associated Diseases In Humansmentioning

confidence: 99%

Helicobacter heilmannii sensu lato: An overview of the infection in humans

Bento-Miranda

Figueiredo

2014

WJG

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“…They were provisionally named "H. heilmannii" after the German pathologist Konrad Heilmann, who first studied the pathology associated with these microorganisms (101). "H. heilmannii" has also been associated with gastritis (40), gastric ulcers (41), and gastric MALT lymphoma (153) but not with gastric adenocarcinoma. Further research on "H. heilmannii" has been seriously hampered by the very fastidious nature of these microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

et al. 2009

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SUMMARY Helicobacters other than Helicobacter pylori have been associated with gastritis, gastric ulcers, and gastric mucosa-associated lymphoid tissue lymphoma in humans. These very fastidious microorganisms with a typical large spiral-shaped morphology were provisionally designated “H. heilmannii,” but in fact they comprise at least five different Helicobacter species, all of which are known to colonize the gastric mucosa of animals. H. suis, which has been isolated from the stomachs of pigs, is the most prevalent gastric non-H. pylori Helicobacter species in humans. Other gastric non-H. pylori helicobacters colonizing the human stomach are H. felis, H. salomonis, H. bizzozeronii, and the still-uncultivable “Candidatus Helicobacter heilmannii.” These microorganisms are often detected in the stomachs of dogs and cats. “Candidatus Helicobacter bovis” is highly prevalent in the abomasums of cattle but has only occasionally been detected in the stomachs of humans. There are clear indications that gastric non-H. pylori Helicobacter infections in humans originate from animals, and it is likely that transmission to humans occurs through direct contact. Little is known about the virulence factors of these microorganisms. The recent successes with in vitro isolation of non-H. pylori helicobacters from domestic animals open new perspectives for studying these microorganisms and their interactions with the host.

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“…Although H. heilmannii infection is rare in humans, it is considered to be of medical importance because of its association with gastritis, gastric ulcer, carcinoma, and mucosa-associated lymphoid tissue lymphoma (15)(16)(17)(18). In contrast to H. pylori infection, H. heilmannii more frequently colonizes the antral gastric mucosa.…”

Section: Introductionmentioning

confidence: 99%

<a name="home"></a>The role of IFN-gamma and IL-4 in gastric mucosa inflammation associated with Helicobacter heilmannii type 1 infection

Cinque

Rocha

Correa-Oliveira

et al. 2006

Braz J Med Biol Res

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Although Helicobacter heilmannii infection is less common than H. pylori infection in humans, it is considered to be of medical importance because of its association with gastritis, gastric ulcer, carcinoma, and mucosa-associated lymphoid tissue lymphoma of the stomach. However, there have been no studies evaluating the role of the Th cell response in H. heilmannii gastric infection. We evaluated the participation of pro-inflammatory and anti-inflammatory cytokines, IFN-γ and IL-4, in H. heilmannii gastric infection in genetically IFN-γ-or IL-4-deficient mice. The serum IFN-γ and IL-4 concentrations were determined by ELISA. The gastric polymorphonuclear infiltrate was higher (P = 0.007) in H. heilmannii-positive than in H. heilmanniinegative wild-type (WT) C57BL/6 mice, whereas no significant inflammation was demonstrable in the stomach of H. heilmannii-positive IFN-γ -/-C57BL/6 mice. The degree of gastric inflammatory cells, especially in oxyntic mucosa, was also higher (P = 0.007) in infected IL-4 -/-than in WT BALB/c mice. Serum IFN-γ levels were significantly higher in IL-4 -/-than in WT BALB/c mice, independently of H. heilmannii-positive or -negative status. Although no difference in serum IFN-γ levels was seen between H. heilmannii-positive (11.3 ± 3.07 pg/mL, mean ± SD) and -negative (11.07 ± 3.5 pg/mL) WT BALB/c mice, in the group of IL-4 -/-animals, the serum concentration of IFN-γ was significantly higher in the infected ones (38.16 ± 10.5 pg/ mL, P = 0.04). In contrast, serum IL-4 levels were significantly decreased in H. heilmannii-positive (N = 10) WT BALB/c animals compared to the negative (N = 10) animals. In conclusion, H. heilmannii infection induces a predominantly Th1 immune response, with IFN-γ playing a central role in gastric inflammation.

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Helicobacter heilmannii and gastric cancer

Cited by 72 publications

References 5 publications

Helicobacter heilmannii sensu lato: An overview of the infection in humans

Helicobacter heilmannii sensu lato: An overview of the infection in humans

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

<a name="home"></a>The role of IFN-gamma and IL-4 in gastric mucosa inflammation associated with Helicobacter heilmannii type 1 infection

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