Helicobacter heilmannii s.l. and peptic ulcer disease – A rare cause

Linhares, Marisa; Pereira, Flávio; Ramos, Diana; Sousa, Rui

doi:10.1016/j.gastrohep.2020.06.035

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“…2 Although H. heilmannii are distinct from the more commonly known Helicobacter pylori (H. pylori), the bacteria have been associated with similar symptoms, including dyspepsia and abdominal pain, as well as micro-and macroscopic inflammation in humans. [3][4][5] Gastric carcinoma, and mucosa-associated lymphoid tissue (MALT) lymphoma, though rare, have also been associated with the infection. 6,7 The diagnosis of H. heilmannii requires identification of the spiral-shaped bacteria during histologic examination of gastric mucosal biopsies obtained during an endoscopy.…”

Section: Introductionmentioning

confidence: 99%

“…Since Dent et al first reported on the presence of H. heilmannii in humans in 1987, 1 several subtypes ( H. suis, H. felis, H. bizzozeronii, H. salomonis, H. cynogastricus , and H. baculiformis ) have been identified using 16S RNA analysis 2 . Although H. heilmannii are distinct from the more commonly known Helicobacter pylori ( H. pylori ), the bacteria have been associated with similar symptoms, including dyspepsia and abdominal pain, as well as micro‐ and macroscopic inflammation in humans 3–5 . Gastric carcinoma, and mucosa‐associated lymphoid tissue (MALT) lymphoma, though rare, have also been associated with the infection 6,7 …”

Section: Introductionmentioning

confidence: 99%

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Clinical presentation and outcomes of Helicobacter heilmannii gastritis in children in the New England region of the United States

Chang,

Gluchowski,

Abu Alfa

et al. 2023

J. pediatr. gastroenterol. nutr.

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ObjectiveTo describe the clinical, endoscopic, histologic, and treatment outcomes of Helicobacter heilmannii (H. heilmannii) associated gastritis in children in the New England region of the United States.MethodsRetrospective study of children (1–18 years) with H. heilmannii identified on gastric mucosal biopsies from two pediatric centers over a 21‐year period, January 2000–December 2021. Cases were identified by querying pathology databases at each institution. Demographic and clinical data were obtained from the medical record. Endoscopic and histologic findings were extracted from endoscopy and pathology reports, respectively.ResultsThirty‐eight children were diagnosed with H. heilmannii‐associated gastritis during the study period. The mean age at diagnosis was 10.1 ± 5.3 years, and 25/38 (66%) cases were male. Abdominal pain (32%) and nausea with or without vomiting (26%) were the most common symptoms. Thirty‐two children (84%) had endoscopic findings including gastric nodularity (55%) and erythema (26%). All children had histologic signs of chronic gastritis, including those with normal endoscopic exams. Antibiotic regimens used for treating Helicobacter pylori were frequently prescribed. Of the 17 children who underwent a follow‐up endoscopy (range 2–68 months), 15 (88%) did not have H. heilmannii identified on gastric biopsies.ConclusionH. heilmannii was an infrequent but potential cause of epigastric abdominal pain and nausea in our cohort of New England children. While morphologically distinct from H. pylori, the bacteria can result in similar endoscopic and histologic findings of nodularity and chronic gastritis, respectively. The rate of eradication, as assessed by histology following treatment with H. pylori therapies, was below the 90% recommended goal for antimicrobial therapies.

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