Helicobacter pylori and autoimmune diseases

Faria, Carolina; Zakout, Raed; Araújo, Mascarenhas

doi:10.1016/j.biopha.2011.09.015

Cited by 11 publications

(8 citation statements)

References 45 publications

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“…For instance, infected individuals may mount a humoral and cellular immune response to bacterial constituents and products that might cross-react with epithelial cells of various organs. (For a comprehensive review on HP infection and autoimmunity, consult [18]. ) In a previous study, we showed that antibodies raised in rabbit against HP, as well as serum samples from HP-infected patients, recognized immunologically human sperm, suggesting the existence of an antigenic mimicry between HP antigens and sperm peptides [5].…”

Section: Resultsmentioning

confidence: 99%

CagA-PositiveHelicobacter pyloriInfection and Reduced Sperm Motility, Vitality, and Normal Morphology

et al. 2013

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Helicobacter pylori (HP) infection, particularly when caused by strains expressing CagA, may be considered a concomitant cause of male and female reduced fertility. This study explored, in 87 HP-infected males, the relationship between infection by CagA-positive HP strains and sperm parameters. HP infection and CagA status were determined by ELISA and Western blotting; semen analysis was performed following WHO guidelines. The amino acid sequence of human enzymes involved in glycolysis and oxidative metabolism were “blasted” with peptides expressed by HP J99. Thirty-seven patients (42.5%) were seropositive for CagA. Sperm motility (18% versus 32%; P < 0.01), sperm vitality (35% versus 48%; P < 0.01) and the percentage of sperm with normal forms (18% versus 22%; P < 0.05) in the CagA-positive group were significantly reduced versus those in the CagA-negative group. All the considered enzymes showed partial linear homology with HP peptides, but four enzymes aligned with four different segments of the same cag island protein. We hypothesize a relationship between infection by strains expressing CagA and decreased sperm quality. Potentially increased systemic levels of inflammatory cytokines that occur in infection by CagA-positive strains and autoimmune phenomena that involve molecular mimicry could explain the pathogenetic mechanism of alterations observed.

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Section: Resultsmentioning

confidence: 99%

CagA-PositiveHelicobacter pyloriInfection and Reduced Sperm Motility, Vitality, and Normal Morphology

et al. 2013

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“…H. pylori is a spiral-shaped, flagellated, gram-negative bacterium, and colonizes the stomach of about 50% of the world’s population [16]. It can cause dyspepsia, acute and chronic gastritis, peptic ulceration, mucosa associated lymphoid tissue lymphoma, and gastric adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of H. pylori infection in the Korean population above 16 years of age was 59.6% in 2005 [15]. Furthermore, extra-gastric diseases, especially autoimmune diseases that might be related to H. pylori infection have received attention recently [16,17]. However, data regarding the relationship between H. pylori infection and thyroid autoimmunity are limited in Asian populations, in which H. pylori infection is extremely prevalent.…”

Section: Introductionmentioning

confidence: 99%

Association between thyroid autoimmunity and Helicobacter pylori infection

Choi

Kim

et al. 2017

Korean J Intern Med

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Background/AimsThere have been controversial reports linking Helicobacter pylori infection to autoimmune thyroid disease (AITD). However, data regarding the relationship are limited for Asian populations, which have an extremely high prevalence of H. pylori infection. We performed this study to investigate the association between H. pylori infection and AITD in Koreans.MethodsThis study involved adults aged 30 to 70 years who had visited a health promotion center. A total of 5,502 subjects were analysed. Thyroid status was assessed by free thyroxine, thyroid stimulating hormone, and anti-thyroid peroxidase antibody (TPO-Ab). Immunoglobulin G (IgG) antibodies to H. pylori were measured as an indication of H. pylori infection. We compared the prevalence of TPO-Ab in subjects with and without H. pylori infection.ResultsH. pylori IgG antibodies were found in 2,875 subjects (52.3%), and TPO-Ab were found in 430 (7.8%). Individuals positive for H. pylori Ab were older than those negative for H. pylori Ab (p < 0.01). The proportion of females was significantly higher in the TPO-Ab positive group (41.0% vs. 64.2%, p < 0.01). Prevalence of TPO-Ab positivity was higher in subjects with H. pylori infection (8.6% vs. 7.00%, p = 0.03), and this association was significant after adjusting for age, sex, and body mass index (odds ratio, 1.02; 95% confidence interval, 1.00 to 1.03; p = 0.04).ConclusionsIn our study, prevalence of TPO-Ab positivity is more frequent in subjects with H. pylori infection. Our findings suggest H. pylori infection may play a role in the development of autoimmune thyroiditis.

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“…B-IRS is caused by circulating polyclonal autoantibodies directed against the insulin receptor, leading to severe insulin resistance with compensated hyperinsulinemia. The plasma glucose profile can show persistent hyperglycemia, fasting hypoglycemia and postprandial hyperglycemia, or fasting and postprandial spontaneous hypoglycemia without hyperglycemia [31,32]. The spontaneous transformation of hyperglycemia into hypoglycemia during the course of the disease commonly signifies a poor prognosis and may even be a cause of death in B-IRS [31,32].…”

Section: Discussionmentioning

confidence: 99%

“…The plasma glucose profile can show persistent hyperglycemia, fasting hypoglycemia and postprandial hyperglycemia, or fasting and postprandial spontaneous hypoglycemia without hyperglycemia [31,32]. The spontaneous transformation of hyperglycemia into hypoglycemia during the course of the disease commonly signifies a poor prognosis and may even be a cause of death in B-IRS [31,32]. The hyperglycemic phase is usually associated with significant weight loss, therefore most individuals are non-obese (BMI < 30 kg/m 2 ) at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Two Autoimmune Dysglycemia Syndromes: Insulin Autoimmune Syndrome (IAS) and Type B Insulin Resistance Syndrome (B-IRS)

Yang

Dou

et al. 2019

Horm Metab Res

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Insulin autoimmune syndrome (IAS) and type B insulin resistance syndrome (B-IRS) are rare autoimmune dysglycemia syndromes, but their treatment and prognosis are different. This study aimed to provide a basis for the clinical differential diagnosis of IAS and B-IRS. This was a retrospective study of the medical records of all patients diagnosed with IAS or B-IRS between January 2006 and March 2018 at the Chinese PLA General Hospital. Demographic, clinical, biochemistry, treatment, and follow-up data were examined. There were several different biochemical parameters between IAS (n=13) and B-IRS (n=6): white blood count (WBC, 7.05±3.06 vs. 2.70±0.73×109/l, p=0.004), platelet (249±56.6 vs. 111±68.0×109/l, p<0.001), serum creatine (59.0±17.8 vs. 43.1±7.05 μmol/l, p=0.013), serum albumin (42.3±5.17 vs. 33.6±3.40 g/l, p=0.002), triglyceride (median, 1.33 (1.01, 1.93) vs. 0.56 (0.50, 0.79) mmol/l, p=0.002), plasma IgG (1183±201 vs. 1832±469 mg/ml, p=0.018), IgA (328±140 vs. 469±150 mg/ml, p=0.018), and C3 (128±23.4 vs. 45.3±13.5 mg/l, p<0.001). Fasting insulin in the IAS and B-IRS patients was high (299–4708 vs. 118–851 mU/l, p=0.106), and there was a difference in 2 h oral glucose tolerance test insulin (4217–8343 mU/l vs. 274–1143 mU/l, p=0.012). Glycated hemoglobin (HbA1c) in the B-IRS patients was higher than in IAS patients (114±14.4. vs. 40.6±8.89 mmol/mol, p<0.001). Serum insulin-like growth factor-1 (IGF-1) was lower in all B-IRS patients (25±0.00 vs. 132±52.7 ng/ml, p<0.001). Although IAS and B-IRS are autoimmune hyperinsulinemic dysglycemic syndromes, several clinical parameters (body mass index, HbA1c, WBC, platelet, albumin, triglyceride, IgG, C3, and IGF-1) are different between these two syndromes.

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Helicobacter pylori and autoimmune diseases

Cited by 11 publications

References 45 publications

CagA-PositiveHelicobacter pyloriInfection and Reduced Sperm Motility, Vitality, and Normal Morphology

CagA-PositiveHelicobacter pyloriInfection and Reduced Sperm Motility, Vitality, and Normal Morphology

Association between thyroid autoimmunity and Helicobacter pylori infection

Comparison of Two Autoimmune Dysglycemia Syndromes: Insulin Autoimmune Syndrome (IAS) and Type B Insulin Resistance Syndrome (B-IRS)

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