Helicobacter pylori and Gastric Cancer

Abstract

Gastric cancer remains a major cause of cancer death worldwide. The discovery of Helicobacter pylori Helicobacter pylori and its association with gastric cancer has opened up new insights into its pathogenesis. Gastric cancer pathogenesis is the result of a complex interplay between bacterial, host and environmental factors resulting in a step wise histological progression to neoplasia. H. pylori is a major factor in the early stages of cancer development and the mechanism of action of its virulence factors are being steadily unravelled. It is also now recognised that host genetic polymorphisms also play a complex role interacting synergistically with the bacterial virulence factors. The role of H. pylori in the causation of gastric cancer also raises the possibility of cancer prevention through screening and eradication, actions which may improve outcomes in high risk populations but which may not be cost-effective in areas of low risk. Ultimately, despite the vast improvements in knowledge, as yet there has not been a corresponding improvement in terms of gastric cancer survival rates.

Relationship between ureB Sequence Diversity, Urease Activity and Genotypic Variations of Different Helicobacter pylori Strains in Patients with Gastric Disorders

“…Association of the severity of H. pylori induced diseases with virulence entity of the colonized strains was reported in several studies. CagA, VacA, IceA, DupA and urease are among the most important virulence factors whose involvement in the progression of these diseases has been established (Rathbone and Rathbone, 2011 (Kusters et al, 2006;Yahav et al, 2000). Urease of H. pylori accounts for about 10% of the total cell protein that is expressed in most of the strains (Suzuki et al, 2007).…”

Single-crystal neutron diffraction studies of hydrogen-bonded systems: Two recent examples from IPNS

“…However, the hydrogen-bonding preference of the individual molecule, particularly when surrounded by aqueous solvent, is of more interest in drug design. This preference was investigated by means of molecular dynamics simulations with AMBER, in vacuo, with implicit water, and with explicit water molecules [12]. These calculations strongly imply that the intramolecular interaction observed in the solid state, with O5 as donor, is preferred over the alternative possibility with O4 acting as donor.…”

Helicobacter pyloriEradication Therapy: Current Availabilities

“…Several randomized controlled trials performed in western countries and in Asia have given opposite results about the role of HP infection in causing FD, with no evidence for the former countries whereas a success of eradication has been obtained in some east Asian populations [70]. As HP may reduce gastric acid secretion, its colonisation has been reported to be inversely associated with the development of GERD [72]. HP infection would be protective towards gastroesophageal disease (GERD).…”