Helicobacter pylori and its association with autoimmune diseases: systemic lupus erythematosus, rheumatoid arthritis and Sjögren syndrome

Etchegaray‐Morales, Ivet; Jiménez-Herrera, Erick Alejandro; Mendoza‐Pinto, Claudia; Rojas-Villarraga, Adriana; Macias-Díaz, Salvador; Osorio-Peña, Ángel David; Munguía‐Realpozo, Pamela

doi:10.1016/j.jtauto.2021.100135

Cited by 11 publications

(12 citation statements)

References 92 publications

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“…While autoimmune diseases, including systemic lupus erythematous, have long been associated with MN, other vague autoimmune syndromes have also been reported, including inflammatory arthritis and ITP [ 14 – 16 ]. Additionally, an association between Helicobacter pylori infection and autoimmune diseases has been previously reported, including SLE, Sjogren's disease, and rheumatoid arthritis [ 17 ]. Although our patient did not exhibit a typical full-house pattern of immunoglobulin deposition in the glomerular basement membrane or any symptoms suggesting autoimmune diseases, including systemic lupus erythematosus or Sjögren's syndrome, he may have had an underlying autoimmune disease or overlapping syndrome because he was positive for anti-Sm and anti-SS-A antibodies even after 5 years post-eradication of his gastric Helicobacter pylori .…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of coexisting membranous nephropathy and immune thrombocytopenia by eradicating gastric Helicobacter pylori infection: a case report

Suetsugu,

Sakuma,

Maruyama

et al. 2023

CEN Case Rep

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Membranous nephropathy (MN) is a common cause of nephrotic syndrome in middle-aged and older adults. MN etiology is mainly primary or idiopathic; however, it may also be secondary to infections, drugs, neoplasms, and autoimmune diseases. We present the case of a 52-year-old Japanese man with coexisting nephrotic MN and immune thrombocytopenic purpura (ITP). Renal biopsy revealed glomerular basement membrane thickening with immunoglobulin (Ig) G and complement component 3 deposition. Glomerular IgG subclass analysis revealed predominant IgG4 deposition with weak IgG1 and IgG2 deposition. IgG3 and phospholipase A2 receptor deposits were negative. Upper endoscopy revealed no ulcers, but histological examination demonstrated Helicobacter pylori infection in the gastric mucosa with elevated IgG antibodies. After gastric Helicobacter pylori eradication, the nephrotic-range proteinuria and thrombocytopenia of the patient were markedly improved without initiation of immunosuppressive treatment. Therefore, clinicians should consider the possibility of Helicobacter pylori infection in patients with coexisting MN and ITP. Further studies are required to demonstrate the associated pathophysiological aspects.

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Section: Discussionmentioning

confidence: 99%

Successful treatment of coexisting membranous nephropathy and immune thrombocytopenia by eradicating gastric Helicobacter pylori infection: a case report

Suetsugu,

Sakuma,

Maruyama

et al. 2023

CEN Case Rep

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“…Furthermore, it is well-documented that H. pylori infection triggers a Th-17 inflammatory response, which is also involved in the pathophysiology of systemic lupus erythematosus [ 224 , 225 ]. In fact, a recent review concluded that H. pylori might have a dichotomous role acting as both a trigger and a protector for systemic lupus erythematosus depending on age, race, and the affected organs [ 125 ].…”

Section: H Pylori and Other Extraintestinal Manifestationsmentioning

confidence: 99%

“…Sjögren syndrome, a systemic autoimmune disease characterized by lymphoplasmocytic infiltration of the exocrine glands resulting in sicca syndrome was also suggested to be associated with H. pylori infection [ 125 ]. H. pylori antibodies were found to be significantly increased in patients with primary Sjögren syndrome as compared to secondary type, other autoimmune diseases, and healthy controls [ 126 ].…”

Section: H Pylori and Other Extraintestinal Manifestationsmentioning

confidence: 99%

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Helicobacter pylori-Related Extraintestinal Manifestations—Myth or Reality

Mărginean

Meliţ

2022

Children

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It is well documented that Helicobacter pylori (H. pylori) can cause both gastrointestinal and extraintestinal manifestations. The latter one represents a major burden in terms of diagnosis and treatment. H. pylori-associated systemic subclinical inflammation is mostly responsible for the development of extraintestinal manifestations, and its early eradication might result in preventing all adverse events related to their occurrence. Thus, it was suggested that H. pylori might be associated with iron deficiency anemia, thrombocytopenia (immune thrombocytopenic purpura), Schonlein Henoch purpura, failure to thrive, vitamin B12 deficiency, diabetes mellitus, body mass index, cardiovascular diseases, as well as certain neurological conditions. Nevertheless, studies showed both pros and cons in terms of the role of H. pylori in the development of previously mentioned clinical entity underlining the crucial need for further studies on these topics. Although most of these extraintestinal manifestations occur during adulthood, we must not forget that H. pylori infection is acquired mainly during childhood, and thus its early diagnosis and eradication might represent the cornerstone in the prevention of H. pylori-induced inflammatory status and consequently of all related extraintestinal conditions.

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“…Third, suppressing the immune system raises the chance of neoplasm, such as gastric cancer. 5 A single organ or a number of organs and systems may be affected by an autoimmune disease, which is a chronic disease that typically results from the loss of immunological tolerance to autoantigens. Since the time H. pylori has been originally discovered in the stomach and then its harmful effect was recognized, modern gastroenterology has advanced significantly.…”

mentioning

confidence: 99%

Helicobacter Pylori infection in rheumatic and autoimmune diseases

Ghamdi

Aljohani²,

Almuawi³

et al. 2022

Int J Community Med Public Health

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Helicobacter pylori (H. pylori) infection is responsible for affecting almost 50% to 80% of people worldwide thus making it quite a prevalent bacterial infection. The relationship between infection and autoimmune disease have grown more obvious over the past 20 years. Although the exact cause of autoimmune diseases is unknown, it has long been hypothesized that genetically susceptible individuals may be more likely to develop autoimmune processes as a result of exposure to specific environmental agents, such as bacterial and viral infections or chemical exposures. One important factor in the development of autoimmune disorders is H. pylori infection. Clinically, H. pylori infection is frequently linked to peptic ulcer disease, while many infected people exhibit no symptoms. Atrophic gastritis, immunological thrombocytopenic purpura, and mucosa associated lymphoid tissue lymphoma are just a few of the illnesses that immune dysregulation has been linked to and reduced by H. pylori. Rheumatoid arthritis, systemic lupus erythematosus, and Sjogren's syndrome are examples of autoimmune diseases caused by an immune system that is malfunctioning in the body and invading healthy tissues. The purpose of this research is to review the available information about H. pylori infection in rheumatic and autoimmune disease. Numerous researchers have proposed that H. pylori may have a role in the emergence of autoimmune diseases due to its frequency and capability to alter human immune function. Although the results from majority of the present study findings in literature are contrasting. Further clinical research is needed to elaborately explain the association between autoimmune diseases and H. pylori infection.

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Helicobacter pylori and its association with autoimmune diseases: systemic lupus erythematosus, rheumatoid arthritis and Sjögren syndrome

Cited by 11 publications

References 92 publications

Successful treatment of coexisting membranous nephropathy and immune thrombocytopenia by eradicating gastric Helicobacter pylori infection: a case report

Successful treatment of coexisting membranous nephropathy and immune thrombocytopenia by eradicating gastric Helicobacter pylori infection: a case report

Helicobacter pylori-Related Extraintestinal Manifestations—Myth or Reality

Helicobacter Pylori infection in rheumatic and autoimmune diseases

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