Helicobacter pylori and Metabolic Diseases

Kim, Sung Eun

doi:10.7704/kjhugr.2019.0038

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…Clinical manifestations of H. pylori infection include gastrointestinal diseases such as gastritis, peptic ulcer disease, gastric mucosa‐associated lymphoid tissue, and non‐cardia gastric adenocarcinoma 3 . Furthermore, H. pylori infection is linked to a number of extra‐gastric diseases, including idiopathic thrombocytopenic purpura, preeclampsia, cardiovascular disease, neurological, anemia, and autoimmune thyroid diseases 4–7 …”

Section: Introductionmentioning

confidence: 99%

Cohort study of Helicobacter pylori infection and the risk of incident osteoporosis in women

Kim

Lee

et al. 2020

J of Gastro and Hepatol

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Background and Aim Previous studies suggested an association between Helicobacter pylori infection and osteoporosis; however, large‐scale longitudinal studies are lacking to elucidate this association. Methods A cohort study of 10 482 women without osteoporosis at baseline who participated in a repeated health‐screening examination including an H. pylori‐specific immunoglobulin G antibody test was conducted to evaluate the association between H. pylori and osteoporosis development. Osteoporosis was diagnosed using dual‐energy X‐ray absorptiometry. Results During the 77 515.3 person‐years of follow‐up, women with H. pylori infection had a higher rate of incident osteoporosis than those who were uninfected. In a multivariable model adjusted for age, body mass index (BMI), menopausal status, smoking status, regular exercise, comorbidities (including hypertension, diabetes mellitus, dyslipidemia, stroke, or ischemic heart disease), and concomitant medications, the hazard ratio (HR) for incident osteoporosis in women with H. pylori infection compared with that in women without infection was 1.23 (95% confidence interval [CI], 1.03–1.45). The association between H. pylori and osteopenia development was also evident. In the multivariable analysis, menopause (HR, 1.68; 95% CI, 1.31–2.16) and increasing age (HR, 1.07; 95% CI, 1.06–1.08) were identified as significant risk factors for osteoporosis, whereas higher BMI (HR, 0.84; 95% CI, 0.81–0.87) was a protective factor for the risk of osteoporosis. Conclusions In this cohort study, H. pylori infection was associated with an increased risk of osteoporosis, independent of risk factors and confounding factors.

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Section: Introductionmentioning

confidence: 99%

Cohort study of Helicobacter pylori infection and the risk of incident osteoporosis in women

Kim

Lee

et al. 2020

J of Gastro and Hepatol

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“…H. pylori infection not only affects the stomach but is also associated with numerous extragastric diseases, including idiopathic thrombocytopenic purpura and iron‐deficiency anemia 8‐10 . Moreover, many studies have reported an association between H. pylori seropositivity and lipid abnormalities, and cardiovascular disease, suggesting a causal relationship that remains controversial 11‐17 …”

Section: Introductionmentioning

confidence: 99%

Eradication of Helicobacter pylori infection decreases risk for dyslipidemia: A cohort study

et al. 2021

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Background Previous studies have suggested a relationship between Helicobacter pylori infection and dyslipidemia; however, large‐scale longitudinal studies have not elucidated this association. This study assessed the longitudinal effects of H. pylori infection and eradication on lipid profiles in a large cohort. Methods This cohort study included 2,626 adults without dyslipidemia at baseline, who participated in a repeated, regular health‐screening examination, which included upper gastrointestinal endoscopy, between January 2009 and December 2018. The primary outcome was incident dyslipidemia at follow‐up. Results During the 10,324 person‐years of follow‐up, participants with persistent H. pylori infection had a higher incidence rate (130.5 per 1,000 person‐years) of dyslipidemia than those whose infections had been successfully controlled (98.1 per 1,000 person‐years). In a multivariable model adjusted for age, sex, waist circumference, smoking status, alcohol intake, and education level, the H. pylori eradication group was associated with a lower risk of dyslipidemia than the persistent group (HR, 0.85; 95% CI, 0.77–0.95; p = 0.004). The association persisted after further adjustment for baseline levels of low‐density and high‐density lipoprotein cholesterol (HR, 0.87; 95% CI, 0.79–0.97; p = 0.014). Conclusions H. pylori infection may play a pathophysiologic role in the development of dyslipidemia, whereas H. pylori eradication might decrease the risk of dyslipidemia.

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Sex differences betweenHelicobacter pyloriinfection and cholesterol levels in an adult health checkup program

et al. 2020

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BackgroundHelicobacter pylori (H pylori) infection is suggested to be a risk factor of metabolic syndrome (MS) and lipid abnormalities. The aim of this study was to investigate the influence of H pylori infection on MS and lipid abnormalities according to sex differences.Materials and MethodsWe analyzed a total of 4551 adults who received health checkups from January 2016 to May 2017. We enrolled participants who did not have a history of hypertension, diabetes, hyperlipidemia, or cancer among those who underwent endoscopy with a rapid urease test.ResultsWe included a total of 1065 participants, and 663 patients (62.3%) were H pylori‐positive. The H pylori infection rate was 59.3% (426/719) in males and 68.5% (237/346) in females. The mean level of total cholesterol (P = .003), low‐density lipoprotein (LDL) cholesterol (P = .046), and triglycerides (P = .029) were statistically higher in H pylori‐infected males. The mean level of high‐density lipoprotein (HDL) cholesterol was statistically lower in H pylori‐infected females (P = .032). Multivariate analysis showed that total cholesterol in males (odds ratio [OR], 1.007; 95% confidence interval [CI], 1.002‐1.011) and HDL cholesterol in females (OR, 0.983; 95% CI, 0.968‐0.998) were associated with active H pylori infection. The prevalence of MS was higher in both male and female H pylori‐infected groups; however, there was no statistical significance.ConclusionsH pylori infection is significantly related to increased total cholesterol in males and to decreased HDL cholesterol in females, which suggests that H pylori could affect lipid profiles and may be different by sex.

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Helicobacter pylori and Metabolic Diseases

Cited by 3 publications

References 51 publications

Cohort study of Helicobacter pylori infection and the risk of incident osteoporosis in women

Cohort study of Helicobacter pylori infection and the risk of incident osteoporosis in women

Eradication of Helicobacter pylori infection decreases risk for dyslipidemia: A cohort study

Sex differences betweenHelicobacter pyloriinfection and cholesterol levels in an adult health checkup program

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