Helicobacter pylori and primary gastric lymphoma

Nakamura, Shotaro; Yao, Takashi; Aoyagi, Kazuhiko; Iida, Mitsuo; Fujishima, Masatoshi; Tsuneyoshi, Masazumi

doi:10.1002/(sici)1097-0142(19970101)79:1<3::aid-cncr2>3.0.co;2-p

Cited by 157 publications

(39 citation statements)

References 34 publications

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“…32 However, lar to those for the previously reported patients with in the current study, H. pylori was detected in all patients (Table 2), even though all 12 lymphomas masgastric adenocarcinoma without lymphoma. …”

Section: Discussionsupporting

confidence: 81%

“…14 - 21,32 with double primary gastric lymphoma and adenocarThe authors' previous study revealed H. pylori to be cinoma were 71% and 36%, respectively (80% and 40%, detected in only 50% of the gastric lymphomas invadrespectively, for early adenocarcinoma, and 0% and ing the deep portion of submucosa or even deeper, in 0%, respectively, for advanced adenocarcinoma), contrast to 90% of those restricted to the mucosa and which appeared to be slightly lower but relatively simithe superficial portion of the submucosa. 32 However, lar to those for the previously reported patients with in the current study, H. pylori was detected in all patients (Table 2), even though all 12 lymphomas masgastric adenocarcinoma without lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…The postoperative survival probability was estimated by the Kaplan -Meier method in 12 patients with douImmunohistochemistry Including the Detection ble primary gastric lymphoma and adenocarcinoma, of H. pylori as well as in 217 patients with primary gastric Immunohistochemical staining for MIB-1 (Ki-67), 1 bcllymphoma without adenocarcinoma, 1 and the com-2, 28 p53, 28 and H. pylori 32 was performed on formalin parisons were calculated using the log rank test. Other fixed, paraffin embedded surgical specimens by the statistical differences were evaluated using either the streptavidin-biotin-peroxidase-complex method using chi-square test or the Mann -Whitney U test.…”

Section: 28mentioning

confidence: 99%

“…In the stomach, an EBV association H. pylori were predigested by trypsin. 32 The primary has been reported in some cases of primary gastric antibodies, including MIB-1 (Immunotech, Marseille, lymphoma [22][23][24] and adenocarcinoma. [25][26][27] France), bcl-2 (clone 124; Dako, Glostrup, Denmark), In the current study, the authors analyzed 12 cases p53 (PAb1801; Oncogene Science, Uniondale, NY), and of coexisting primary gastric lymphoma and adenocar-H. pylori (B471; Dako, Glostrup, Denmark), were apcinoma in the same patient observed either synchroplied overnight at 4 ЊC, followed by incubation with nously or metachronously to delineate the clinicosecondary biotinylated antibody for 20 minutes, and pathologic and immunohistochemical features, as well a streptavidin-biotin-peroxidase complex reagent was as to assess the possible association with H. pylori and then applied for 20 minutes at room temperature.…”

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Synchronous and metachronous primary gastric lymphoma and adenocarcinoma

Nakamura

Aoyagi

Iwanaga

et al. 1997

Cancer

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RESULTS.Two different tumors were found synchronously in 10 patients (5 with Masatoshi Fujishima, M.D. 2 independent tumors and 5 with contiguous/collision tumors) and metachronously in 2. The size of the lymphomas (mean, 7.2 cm) was larger than that of the adeno-1 Second Department of Pathology, Faculty of carcinomas (mean, 3.6 cm) (P õ 0.005). Histologically, 9 of the 12 lymphomas Medicine, Kyushu University, Fukuoka, Japan.(75%) were mucosa-associated lymphoid tissue lymphomas, and all lymphomas 2 Second Department of Internal Medicine, Facinvaded the deep portion of the submucosa or deeper. Conversely, 10 of the 12 ulty of Medicine, Kyushu University, Fukuoka, adenocarcinomas (83%) were early carcinomas. Six adenocarcinomas were intestiJapan.nal type, whereas the other 6 were diffuse type. The MIB-1 index of the adenocarci-3 First Department of Pathology, School of Mednomas (mean, 50.4%) was higher than that of the lymphomas (mean, 29.3%) (P õ icine, Fukuoka University, Fukuoka, Japan. 0.05). Helicobacter pylori (H. pylori) was documented in all 12 patients, whereasEpstein-Barr virus-encoded RNA 1 was detected in only 2. During the followup period after surgery, 6 patients died, 4 due to adenocarcinoma. The survival probability of all 12 patients appeared to be similar to that of previously reported patients with gastric adenocarcinoma alone, and was significantly worse than that of the 217 patients with gastric lymphoma alone (P õ 0.05).CONCLUSIONS. An H. pylori infection is considered to be associated with the development of these double malignancies. In many such synchronously observed cases, lymphomas may precede carcinogenesis, while the prognosis appears to be more closely associated with the adenocarcinoma than the lymphoma. G astric adenocarcinoma is one of the most common malignancies, whereas primary gastric lymphoma is relatively uncommon, oc-The authors thank Dr. Koh-ichi Ohshima and curring in only 1 -7% of all malignant neoplasms of the stomach. Dr. Akinori Iwashita, Fukuoka University, forThe occurrence of both malignant gastric lymphoma and adenocarcitheir kind cooperation, and Brian T. Quinn for noma in the same patient is very rare, and little is known regarding his critical comments.the clinicopathologic characteristics of such cases. 2-13Address for reprints: Shotaro Nakamura, M.D.,Helicobacter pylori (H. pylori) is believed to play a causative role nocarcinomas but also primary gastric lymphomas, especially those of mucosa-associated lymphoid tissue (MALT) type, are associated

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: 28mentioning

confidence: 99%

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confidence: 99%

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Synchronous and metachronous primary gastric lymphoma and adenocarcinoma

Nakamura

Aoyagi

Iwanaga

et al. 1997

Cancer

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“…It has also been implicated in gastric adenocarcinoma (6 -9) and gastric lymphoma (10), leading to its classification as a type I human carcinogen (11). H. pylori is a chronic pathogen, and the means by which this organism is able to persist in the stomach and resist or evade destruction by the immune system is central to its involvement in disease.…”

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confidence: 99%