Helicobacter pylori Associated With Obstructive Sleep Apnea Might Contribute to Sleep, Cognition, and Driving Performance Disturbances in Patients With Cirrhosis

Kountouras, Jannis; Deretzi, Georgia

doi:10.1016/j.cgh.2015.02.009

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…There are even several studies that have focused on the association of H. pylori itself with OSA. Whether such infectious etiologies play an important role in the pathophysiology of OSA and its comorbidities is a topic that requires further investigations [155][156][157][158][159][160][161][162].…”

Section: Choroidal Layermentioning

confidence: 99%

The Associations of Obstructive Sleep Apnea and Eye Disorders: Potential Insights into Pathogenesis and Treatment

Ahn

Gorin²

2021

Curr Sleep Medicine Rep

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Purpose of Review Obstructive sleep apnea (OSA) patients are at significantly increased risks for cardiovascular and cerebrovascular morbidities. Recently, there has been heightened interest in the association of OSA with numerous ocular diseases and possible improvement of these conditions with the initiation of OSA treatment. We reviewed the current evidence with an emphasis on the overlapping pathogeneses of both diseases. Recent Findings Currently available literature points to a substantial association of OSA with ocular diseases, ranging from those involving the eyelid to optic neuropathies and retinal vascular diseases. Since the retina is one of the highest oxygen-consuming tissues in the body, the intermittent hypoxia and hypercapnia ensuing in OSA can have deleterious effects on ocular function and health. Tissue hypoxia, autonomic dysfunction, microvascular dysfunction, and inflammation all play important roles in the pathogenesis of both OSA and ocular diseases. Whether OSA treatment is capable of reversing the course of associated ocular diseases remains to be determined. It is anticipated that future therapeutic approaches will target the common underlying pathophysiologic mechanisms and promote favorable effects on the treatment of known associated ocular diseases. Summary Emerging evidence supports the association of ocular diseases with untreated OSA. Future studies focusing on whether therapeutic approaches targeting the common pathophysiologic mechanisms will be beneficial for the course of both diseases are warranted.

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Section: Choroidal Layermentioning

confidence: 99%

The Associations of Obstructive Sleep Apnea and Eye Disorders: Potential Insights into Pathogenesis and Treatment

Ahn

Gorin²

2021

Curr Sleep Medicine Rep

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show abstract

“…Hp may be involved in HE and post-HE persistent cognitive dysfunction pathophysiology by releasing proinflammatory and vasoactive substances involved, through blood-brain barrier (BBB) disruption, in brain pathologies; Hp might access the brain via the oral-nasal-olfactory pathway or by circulating monocytes (infected with Hp due to defective autophagy) through disrupted BBB, leading to neurodegeneration [4-6]. Likewise, human defensins might also contribute to Hp -related brain pathophysiology by modulating innate and adaptive immune system responses [7].…”

mentioning

confidence: 99%

Potential Impact of Helicobacter Pylori on Hepatic Encephalopathy Pathophysiology

et al. 2018

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“…Finally, based on histological analysis for H. pylori documentation, we reported an association between H. pylori infection and obstructive sleep apnea (OSA) accompanied by increased inflammatory mediators, including TNF-a, IL-1b, IL-8, and reactive oxygen species. These mediators contribute to OSA and asthma pathophysiology (8)(9)(10), and the OSA prevalence in asthma patients is considerably higher (11).…”

mentioning

confidence: 99%

Comment on “Therapeutic Application of an Extract of Helicobacter pylori Ameliorates the Development of Allergic Airway Disease”

Kountouras

Doulberis

Stergiopoulos

et al. 2018

The Journal of Immunology

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Helicobacter pylori Associated With Obstructive Sleep Apnea Might Contribute to Sleep, Cognition, and Driving Performance Disturbances in Patients With Cirrhosis

Cited by 6 publications

References 6 publications

The Associations of Obstructive Sleep Apnea and Eye Disorders: Potential Insights into Pathogenesis and Treatment

The Associations of Obstructive Sleep Apnea and Eye Disorders: Potential Insights into Pathogenesis and Treatment

Potential Impact of Helicobacter Pylori on Hepatic Encephalopathy Pathophysiology

Comment on “Therapeutic Application of an Extract of Helicobacter pylori Ameliorates the Development of Allergic Airway Disease”

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