2021
DOI: 10.1016/j.amsu.2021.102651
|View full text |Cite
|
Sign up to set email alerts
|

Helicobacter pylori co-infection with Epstein-Barr virus and the risk of developing gastric adenocarcinoma at an early age: Observational study infectious agents and cancer

Abstract: Background Gastric cancer (GC) is one of the leading causes of morbidity and mortality worldwide. The onset and progression of gastric cancer are attributed to numerous triggers, these triggers may be infection of the gastric epithelium by Helicobacter pylori ( H. pylori ), or by Epstein-Barr virus (EBV). Both agents can establish a lifelong persistent infection in the host, leading to chronic inflammation, which also contributes to cancer deve… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
15
1
2

Year Published

2021
2021
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 17 publications
(18 citation statements)
references
References 46 publications
0
15
1
2
Order By: Relevance
“… 17 EBV infection can promote the hypermethylation of tumor suppressor genes, inflammation of gastric mucosa, and immune evasion of the host, resulting in gastric carcinogenesis. 18 As sustained infection with H. pylori and EBV can cause chronic inflammatory stress in the stomach, there is emerging attention to GC risk and co-infection by both pathogens, since H. pylori co-infection with EBV increases the occurrence of GC 19 , 20 and may stimulate aggressiveness of GC. 21 …”
Section: Introductionmentioning
confidence: 99%
“… 17 EBV infection can promote the hypermethylation of tumor suppressor genes, inflammation of gastric mucosa, and immune evasion of the host, resulting in gastric carcinogenesis. 18 As sustained infection with H. pylori and EBV can cause chronic inflammatory stress in the stomach, there is emerging attention to GC risk and co-infection by both pathogens, since H. pylori co-infection with EBV increases the occurrence of GC 19 , 20 and may stimulate aggressiveness of GC. 21 …”
Section: Introductionmentioning
confidence: 99%
“…One of these is the interaction between H. pylori and EBV in the TME, which synergizes malignant transformation. In fact, patients co-infected with EBV and H. pylori developed gastric cancer earlier in life than those without co-infection and were also noted to have more aggressive disease [ 59 ]. Some studies have hypothesized that the chronic inflammatory reaction in response to H. pylori recruits lymphocytes infected by EBV, enhancing the chances of their interaction with gastric epithelial cells [ 59 ].…”
Section: Microbial Community As Part Of the Tme: Ebv And H ...mentioning
confidence: 99%
“…One of these is the interaction between H pylori and EBV in the TME, which synergizes malignant transformation. In fact, patients co-infected with EBV and H pylori developed gastric cancer earlier in life than those without co-infection and were also noted to have more aggressive disease [49].…”
Section: Microbial Community As Part Of the Tme: Ebv And H Pylori Coi...mentioning
confidence: 99%
“…Some studies hypothesize that the chronic inflammatory reaction in response to H pylori recruits lymphocytes infected by EBV, enhancing the chances of their interaction with gastric epithelial cells [49]. In addition, co-infection creates a TME that is more advantageous for malignant transformation.…”
Section: Microbial Community As Part Of the Tme: Ebv And H Pylori Coi...mentioning
confidence: 99%
See 1 more Smart Citation