Helicobacter pylori Cytotoxin-Associated Genotype and Gastric Precancerous Lesions

Plummer, Martyn; Doorn, Leen Jan Van; Franceschi, Silvia; Kleter, Bernhard; Canzian, Federico; Vivas, Jorge; López, Gladys; Colin, Didier; Muñóz, Núbia; Kato, Ikuko

doi:10.1093/jnci/djm120

Cited by 99 publications

(81 citation statements)

References 27 publications

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“…Because the vacA gene is present in all H. pylori strains, we used this marker to identify patients with H. pylori infection. 7,8 We emphasize that PCR analysis has been reported to be associated with a higher sensitivity when compared with other detection methods such as bacterial culture or histologic analysis. 18 Serologic positivity in our series (77%) was similar to the overall rate reported in a recent meta-analysis including a large number of gastric cancer patients.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical outcome of H. pylori infection may be because of several factors, such as age at the time of first infection, environmental factors, immune response, and genetic characteristics. 7 The vacA gene is present in all H. pylori strains and encodes the vacuolating cytotoxin VacA, which induces epithelial cell injury. The gene comprises 2 variable regions: m (middle region) and s (signal peptide).…”

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confidence: 99%

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Negative Helicobacter pylori status is associated with poor prognosis in patients with gastric cancer

Marrelli

Pedrazzani

Berardi

et al. 2009

Cancer

119

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NELL‐1 (Nel‐like molecule‐1) is a secreted osteogenic growth factor first identified in human craniosynostosis (CS) patients. NELL‐1 protein has been observed to promote bone and cartilage differentiation and to suppress adipogenesis in both in vitro and in vivo models. Despite these findings, the cell surface receptors of NELL‐1 have remained unknown. In this study, we observed for the first time that NELL‐1 promotes cell adherence in multiple cell lines, including ST2, C3H10T1/2, M2‐10B4, ATDC5, and MC3T3 cells. Additionally, we found that NELL‐1 binds to extracellular Integrinβ1 and induces cell focal adhesion. By utilizing siRNA methods, we determined that NELL‐1 cell surface binding and enhanced cell attachment were dependent on Integrinβ1 expression. Finally, we observed that pre‐coating of culture dishes or PLGA (polylactic‐co‐glycolic acid) scaffold with NELL‐1 resulted in a significant increase in both cell attachment and osteogenic differentiation. Our results identify for the first time a cell surface target of NELL‐1, Integrinβ1, and elucidate new functions of NELL‐1 in promoting cell adherence and osteogenic differentiation. J. Cell. Biochem. 113: 3620–3628, 2012. © 2012 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Negative Helicobacter pylori status is associated with poor prognosis in patients with gastric cancer

Marrelli

Pedrazzani

Berardi

et al. 2009

Cancer

119

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“…In fact, the presence of H. pylori DNA in gastric biopsies, the severity of precancerous lesions, and hence gastric cancer risk, appear to be specific of cagA positive strains. [35][36][37][38] Another important cause of stomach cancer is tobacco smoking. Smokers have a 50-60% increased risk of stomach cancer, as compared to nonsmokers.…”

Section: Discussionmentioning

confidence: 99%

Recent patterns in gastric cancer: A global overview

Bertuccio

Chatenoud

Levi

et al. 2009

Intl Journal of Cancer

570

434

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Until the mid-1990s, gastric cancer has been the first cause of cancer death worldwide, although rates had been declining for several decades and gastric cancer has become a relatively rare cancer in North America and in most Northern and Western Europe, but not in Eastern Europe, Russia and selected areas of Central and South America or East Asia. We analyzed gastric cancer mortality in Europe and other areas of the world from 1980 to 2005 using joinpoint regression analysis, and provided updated site-specific incidence rates from 51 selected registries. Over the last decade, the annual percent change (APC) in mortality rate was around 23, 24% for the major European countries. The APC were similar for the Republic of Korea (APC 5 24.3%), Australia (23.7%), the USA (23.6%), Japan (23.5%), Ukraine (23%) and the Russian Federation (22.8%). In Latin America, the decline was less marked, but constant with APC around 21.6% in Chile and Brazil, 22.3% in Argentina and Mexico and 22.6% in Colombia. Cancers in the fundus and pylorus are more common in high incidence and mortality areas and have been declining more than cardia gastric cancer. Steady downward trends persist in gastric cancer mortality worldwide even in middle aged population, and hence further appreciable declines are likely in the near future. ' 2009 UICC

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“…If eradication is done too late, the point of no return for cancer risk may have passed in many individuals (59). Stratifying populations (60) and developing biomarkers that accurately predict risk (39,61) are critical to resolving this dilemma.…”

Section: Challenges Facing Cancer Preventive Interventionsmentioning

confidence: 99%

“…Progress in the field will require better clinical diagnostics to identify specific agents, specific microbial genotypes, specific host genotypes, and other critical factors of the host-microbe interaction (61,66,67). To eliminate the tendency for certain persistent microbes to push toward malignancies, we will need new pharmacologic approaches based on a better understanding of host-microbe interactions.…”

Section: The Futurementioning

confidence: 99%

Understanding Microbe-Induced Cancers

Blaser

2008

Cancer Prevention Research

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Microbes are important causes of human cancers, and our estimation of their significance continues to grow as cancer biology is better dissected. A classification system is proposed that highlights common and proposed microbe-induced pathways toward oncogenesis, with an emphasis on types of targeted cells and host-microbial interactions. The central principles that underlie oncogenesis induced by the many diverse microbes and the major mechanisms involved are outlined. The phenomenon of microbe-induced cancers raises a number of important biological questions, the solving of which may inform other fields, including aging and degenerative disorders. Finally, our challenge for the future is to better understand the steps in microbe-induced cancers to optimize both prevention and therapy.

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Helicobacter pylori Cytotoxin-Associated Genotype and Gastric Precancerous Lesions

Cited by 99 publications

References 27 publications

Negative Helicobacter pylori status is associated with poor prognosis in patients with gastric cancer

Negative Helicobacter pylori status is associated with poor prognosis in patients with gastric cancer

Recent patterns in gastric cancer: A global overview

Understanding Microbe-Induced Cancers

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