Helicobacter pylori eradication and reinfection

Bell, G. D.; Powell, K.; Savarino, Vincenzo; Mela, Giuseppe Sandro; Vigneri, Sergio; Celle, G; Treiber, Gerhard; Klotz, O.; Gomollón, Fernando; Bajador, Eduardo; Boer, Wink de; Ziekenhuis, Sint Anna; Tytgat, G. N. J.

doi:10.1016/s0140-6736(95)90155-8

Cited by 8 publications

(4 citation statements)

References 10 publications

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“…Several reports have shown that lower the efficacy of the original treatment, the greater the likelihood that recurrence will occur, suggesting that the efficacy of the original treatment is predictive of the recurrence of H. pylori . In this study, recurrence rate within 2 years of first‐line triple therapy was higher than that of second‐line quadruple therapy.…”

Section: Discussionmentioning

confidence: 49%

Helicobacter pylori Recurrence after First‐ and Second‐Line Eradication Therapy in Korea: The Problem of Recrudescence or Reinfection

et al. 2014

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Section: Discussionmentioning

confidence: 49%

Helicobacter pylori Recurrence after First‐ and Second‐Line Eradication Therapy in Korea: The Problem of Recrudescence or Reinfection

et al. 2014

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“…An effective eradication regimen for duodenal ulcer disease should achieve high eradication rates to reduce the incidence of recrudescence of the infection in treated patients, as shown by OAM in this study. 21 Furthermore, as the OAM triple therapy strategy used here provided such a high eradication rate, unless symptoms persist, the need to con®rm H. pylori eradication by conducting a second breath test is reduced. Recent developments have now provided the general practitioner access to other less expensive and easier to use diagnostic tests for H. pylori, which may obviate the need for laboratory tests to diagnose the infection.…”

Section: Discussionmentioning

confidence: 99%

“…20 Recrudescence of the infection, where eradication therapy has merely suppressed rather than cleared the infection, is thought to be associated with less effective eradication treatments such as standard triple therapy. 21 Experiences with other therapies have led to the development of more effective eradication regimens which are less complex and better tolerated by the patient. Previous hospital-based work in the UK has shown that treatment with omeprazole triple therapy (omeprazole, amoxycillin and metronidazole) gives rates of 92, 89 and 90%.…”

Section: Introductionmentioning

confidence: 99%

Two omeprazole‐based Helicobacter pylori eradication regimens for the treatment of duodenal ulcer disease in general practice

Cottrill¹,

McKinnon²,

Mason³

et al. 1997

Aliment Pharmacol Ther

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INTRODUCTIONHelicobacter pylori is now thought to be the most important exogenous factor in the development of duodenal ulcer disease, and is present in over 95% of duodenal ulcer patients. 1, 2 Several studies have provided strong evidence that eradication of the infection reduces ulcer relapse rate, 3±5 so it has been suggested that an attempt to eradicate the infection should be made in all patients with duodenal ulcer disease. 6 Eradication therapy therefore offers a potential cure for the disease and provides the general practitioner with an alternative to long-term treatment with acid-lowering SUMMARY Background: Helicobacter pylori is the main acquired factor in the pathogenesis of duodenal ulcer disease. Methods: This multicentre study conducted in 32 general practice centres in the UK and Ireland was a double-blind, placebo-controlled, randomized, parallelgroup comparison of triple therapy (n 98: omeprazole 40 mg once daily and amoxycillin 1 g b.d. for 2 weeks, and metronidazole 400 mg t.d.s. for the ®rst week) and dual therapy (n 85: omeprazole 40 mg once daily and amoxycillin 1 g b.d. for 2 weeks, with placebo during the ®rst week) for the eradication of H. pylori in patients with symptomatic duodenal ulcer disease. Patients who were successfully treated entered a followup phase for 12 months to assess symptomatic relapse and use of health-care resources. Results: Eradication of H. pylori based on a second 13 C-urea breath test was successful in 95% (95% con®dence interval (CI) 90±100%) of patients receiving omeprazole triple therapy and 53% (95% CI 41±65%) of those receiving omeprazole dual

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“…In adults, reinfection or recrudescence occasionally occurs within 12 months after eradication therapy, with an overall 12‐month recurrence rate of 17% (20). One study using DNA fingerprinting showed that the pretreatment and posteradication isolates (within 12 months) obtained from patients are indistinguishable from one another (21). Similarly, more effective eradication therapy is associated with a lower rate of reinfection (22).…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Reinfection Rates in Children After Eradication Therapy

Kato,

Abukawa,

Furuyama

et al. 1998

J. pediatr. gastroenterol. nutr.

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Background:There are few studies of Helicobacter pylori reinfection in childhood. In the current study the reinfection rate of H. pylori and ulcer recurrence were investigated during a follow‐up period of 12 months or more in children who had undergone eradication therapy.Methods:Twenty‐seven patients aged 5 to 16 years (6 with gastric ulcer, 13 with duodenal ulcer, and 8 with nodular gastritis) were studied. Biopsy‐based H. pylori tests performed 1 to 2 months after eradication therapy demonstrated that eradication was successful in 23 patients (5 with gastric ulcer, 11 with duodenal ulcer, and 7 with nodular gastritis) and unsuccessful in 4 (1 with gastric ulcer, 2 with duodenal ulcer, and 1 with nodular gastritis). Twenty‐three successfully treated patients were observed for a mean of 22 months (a total of 42.2 patient years of follow‐up). To assess H. pylori status, all 23 patients underwent a 13C‐urea breath test 1 year after eradication therapy. If the test result was negative, the patients underwent the follow‐up test once every year thereafter. In successfully and unsuccessfully treated patients, endoscopy was performed if a patient reported symptoms suggesting ulcer recurrence.Results:The initial follow‐up 13C‐urea breath tests showed that all 23 patients remained free of infection at 12 to 19 months. Among 17 patients, the second test confirmed reinfection in 1 at 28 months. In two patients studied, the third test showed a negative result. The reinfection rate was 2.4% per patient year. Over the follow‐up period, ulcer recurrence was found in 2 of 3 ulcer patients with eradication failure but in none of the 16 ulcer patients with successful eradication. The recurrence rate was significantly lower in successfully treated patients than in unsuccessfully treated patients (p < 0.05).Conclusions:Reinfection with H. pylori is rare in children aged more than 5 years, and successful eradication significantly reduces ulcer recurrence. This study supports the benefit of eradication therapy in older children.

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Helicobacter pylori eradication and reinfection

Cited by 8 publications

References 10 publications

Helicobacter pylori Recurrence after First‐ and Second‐Line Eradication Therapy in Korea: The Problem of Recrudescence or Reinfection

Helicobacter pylori Recurrence after First‐ and Second‐Line Eradication Therapy in Korea: The Problem of Recrudescence or Reinfection

Two omeprazole‐based Helicobacter pylori eradication regimens for the treatment of duodenal ulcer disease in general practice

Helicobacter pylori Reinfection Rates in Children After Eradication Therapy

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