Helicobacter pylori eradication for the treatment of low-grade gastric MALT lymphoma: Follow-up together with sequential molecular studies

Montalbán, Carlos; Manzanal, A.; Boixeda, D; Redondo, Clara; Álvarez, Isabel; Calleja, J.L.; Bellas, Carmen

doi:10.1093/annonc/8.suppl_2.s37

Cited by 52 publications

(36 citation statements)

References 13 publications

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“…The presence of follicular cholecystitis is a histological change that may be related to the presence of Helicobacter spp as such as the development of MALT lymphoma in the stomach. Even if there was no correlation between microscopic and molecular methods, and that not all the bacilli Giemsa were demonstrated as helicobacter, this finding suggests that the presence of bacteria may be responsible for stimulation of lymphocytes and the generation of clones of cells to lymphoid follicles 3,10,17 . An average age of 57 years was found for the appearance of lymphoid follicles in relation to patients who showed no such condition, suggests that the time of exposure to the bacillus have a crucial role in the development of follicular cholecystitis.…”

Section: Discussionmentioning

confidence: 90%

“…Besides ulcerous disease, H. pilory is related to the development of gastric adenocarcinoma and MALT lymphoma in the stomach 3 . Recent work demonstrated the presence of H. pylori and H. bilis both in the bile and gallbladder of more than 75% of patients with gallbladder's cancer and more than 50% of patients with chronic cholecytitis undergoing surgery 4 .…”

Section: Introductionmentioning

confidence: 99%

“…In the histology of tumors of the gallbladder, the inflammatory process is commonly seen 12 . Similar to the development of lowgrade MALT lymphoma in the stomach due to chronic infection of H. pylori 3 , we seek to establish whether there is a relationship with the presence of lymphoid follicles (follicular cholecystitis) and the presence of helicobacter.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Helicobacter spp in chronic cholecystitis and correlation with changes on the histological pattern of the gallbladder

et al. 2010

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Prevalence of Helicobacter spp in chronic cholecystitis and correlation with changes on the histological pattern of the gallbladder 1Prevalência do Helicobacter spp na colecistite crônica calculosa e correlação com as alterações histológicas da vesícula biliar ABSTRACT Purpose: Establish the prevalence of Helicobacter spp in chronic cholecystitis and its correlation with the gallbladder's histological findings. Methods: 100 patients were operated for chronic cholecystitis with cholecystolithiasis. In pathological examination of the gallbladder, were evaluated the presence of metaplasia, dysplasia, lymphoid follicles, anaplasia and tumors that might be related to the presence of Helicobacter plus the presence of the bacilli Giemsa by optical microscopy. From the DNA extracted from the gallbladder's bile, PCR was performed by using specific primers for the identification of Helicobacter spp with amplification of the 400bp segment of rRNA gene16S, with positive control DNA from Helicobacter pylori. All the cases negative for isolation of genetic material were excluded. The cases of PCR and Giemsa were used as negative control group. The histological findings were compared to the presence of bacilli and PCR data using a chi-square and Fisher's Exact test (CI = 95.0%, p <0.05). Results: Of 68 patients, 42 (61.8%) were PCR for Helicobacter spp and 19 (27.9%) had Giemsa . There was no correlation between the two findings. The PCR for Helicobacter spp was not correlated to the histological findings. The presence of lymphoid follicles and metaplasia was related to the Giemsa (p = 0.025 and p= 0.039). Conclusion: There is high prevalence of Helicobacter spp in patients with chronic cholecystitis and cholecystolithiasis without be correlated with the histological patterns studied.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence of Helicobacter spp in chronic cholecystitis and correlation with changes on the histological pattern of the gallbladder

et al. 2010

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“…136 Following the removal of this immunological drive by eradication of H pylori, the lymphoma, in particular the low-grade MALT lymphoma, is reported to show clinical and histological regression. [138][139][140][141][142] Similarly, various infectious agents capable of inducing chronic ocular inflammation could play a role in the pathogenesis of PIOL.…”

Section: Infectious Agents May Play a Role In Piol Patho-genesis And mentioning

confidence: 99%

Molecular pathology of primary intraocular lymphoma

Chan¹

2004

American Journal of Ophthalmology

129

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“…Primary immune thrombocytopenia [26][27][28][29][30][31][32][33]36,37,40,43,48,62 Low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma [50][51][52][53]62 Controversial hematologic associations with H. pylori infection Pernicious anemia [54][55][56] Monoclonal gammopathy of undetermined significance 57,58 Myelodysplastic syndrome 59 …”

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confidence: 99%