Helicobacter pylori eradication reduces risk for recurrence of gastric hyperplastic polyp after endoscopic resection

Abstract

Background/Aims: Little is known about the effect of <i>Helicobacter pylori</i> eradication on the recurrence of gastric hyperplastic polyps after endoscopic resection. Thus, we evaluated the recurrence rate of gastric hyperplastic polyps based on <i>H. pylori</i> eradication following endoscopic resection.Methods: We retrospectively reviewed the medical records of 201 patients with <i>H. pylori</i> infection who underwent endoscopic resection for gastric hyperplastic polyps at six medical centers. <i>H. pylori</i> status was assessed by histological analysis and a rapid urease test. A total of 149 patients underwent successful <i>H. pylori</i> eradication (eradication group), whereas 52 patients had persistent <i>H. pylori</i> infections (non-eradication group). The recurrence rate of gastric hyperplastic polyps and the risk factors according to <i>H. pylori</i> status were analyzed.Results: During the mean follow-up period of 18.3 months, recurrent gastric polyps developed after endoscopic resection in 10 patients (19.2% [10/52]) in the non-eradication group and 12 patients (8.1% [12/149]) in the eradication group. The cumulative incidence of recurrent gastric hyperplastic polyps was significantly higher in the non-eradication group than in the eradication group (p = 0.041, log‐rank test). In the adjusted analysis, H. pylori eradication reduced the recurrence of gastric hyperplastic polyps (hazard ratio [HR], 0.42; 95% confidence interval [CI], 0.18 to 0.99), whereas anticoagulation therapy increased the risk of recurrence of gastric hyperplastic polyps (HR, 4.91; 95% CI, 1.39 to 17.28).Conclusions: Successful eradication of <i>H. pylori</i> may reduce the recurrence of gastric hyperplastic polyps in patients after endoscopic mucosal resection.

Relationship between Helicobacter pylori infection and colorectal polyp/colorectal cancer

“…Triple treatment coupled with long-term use of proton pump inhibitors may lower the incidence of CAP caused by H. pylori infection[ 32 ], and H. pylori eradication before to surgery may become a novel immunotherapy method for CRC[ 33 ]. In contrast, if H. pylori is not adequately treated and continues, it might considerably increase the recurrence risk of CAP[ 34 - 36 ].…”

Helicobacter pylori eradication reduces risk for recurrence of gastric hyperplastic polyp after endoscopic resection

“…In this study, authors focused on the effect of H. pylori eradication on the recurrence of gastric hyperplastic polyps after endoscopic resection [15]. Most artificial ulcers caused by endoscopic submucosal resection (EMR) or dissection healed similarly to benign gastric ulcer scars, but in several cases, they would take the form of protruded lesions.…”

Colonoscopy plays an important role in detecting colorectal neoplasms in patients with gastric neoplasms

“…According to the International Agency for Research on Cancer, gastric cancer (GC) is the fifth most common cancer worldwide, accounting for 1.1 million new cancer cases[ 1 , 2 ]. Helicobacter pylori (H. pylori) infection is the greatest known risk factor for GC and shows a positive association with gastric polyps[ 3 , 4 ]. Gastric polyps are asymptomatic lesions found incidentally during endoscopy that may develop into GC.…”