Helicobacter pylori: History and facts in Peru

Tirado-Hurtado, Indira; Carlos, Cristian; Lancho, Luciana; Alfaro, Alejandro; Ponce‐Cusi, Richard; Schwarz, Luis J.; Torres, Layonel; Ayudant, Michael; Pinto, Joseph A.; Fajardo, Williams

doi:10.1016/j.critrevonc.2018.12.005

Cited by 12 publications

(9 citation statements)

References 83 publications

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“…Helicobacter pylori ( H. pylori ) is a spiral, microanaerobic, gram-negative bacterium that is very demanding on growth conditions. In 1983, it was successfully isolated from gastric mucosal biopsies from patients with chronic active gastritis [55]. It is the only microbial species known to survive in the human stomach.…”

Section: Chronic Inflammation In Different Types Of Cancersmentioning

confidence: 99%

Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles

2019

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A strong relationship exists between tumor and inflammation, which is the hot point in cancer research. Inflammation can promote the occurrence and development of cancer by promoting blood vessel growth, cancer cell proliferation, and tumor invasiveness, negatively regulating immune response, and changing the efficacy of certain anti-tumor drugs. It has been demonstrated that there are a large number of inflammatory factors and inflammatory cells in the tumor microenvironment, and tumor-promoting immunity and anti-tumor immunity exist simultaneously in the tumor microenvironment. The typical relationship between chronic inflammation and tumor has been presented by the relationships between Helicobacter pylori, chronic gastritis, and gastric cancer; between smoking, development of chronic pneumonia, and lung cancer; and between hepatitis virus (mainly hepatitis virus B and C), development of chronic hepatitis, and liver cancer. The prevention of chronic inflammation is a factor that can prevent cancer, so it effectively inhibits or blocks the occurrence, development, and progression of the chronic inflammation process playing important roles in the prevention of cancer. Monitoring of the causes and inflammatory factors in chronic inflammation processes is a useful way to predict cancer and assess the efficiency of cancer prevention. Chronic inflammation-based biomarkers are useful tools to predict and prevent cancer.

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Section: Chronic Inflammation In Different Types Of Cancersmentioning

confidence: 99%

Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles

2019

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“…Another factor that could influence the interest on gastric cancer is the low level of knowledge of the population, a Chinese study and another Peruvian study concluded that the general population has a low to medium level of awareness on the topic [45,46]. The coastal provinces: La Libertad, Lambayeque, Sierra: Áncash, Junín and Huánuco had higher RSV for this search topic, which could be related to the fact that these regions correspond to the areas with the highest incidence and mortality from gastric cancer in recent years, a fact that has been associated with social determinants of health such as: poverty, sanitation and exposure to other risk factors [47][48][49]. The correlation between incidence and RSV was not statistically significant.…”

Section: Gastric Cancermentioning

confidence: 99%

Impact of cancer awareness campaigns in Peru: a 5-year Google Trends analysis

Luna‐Abanto¹,

Gamarra²,

Armestar³

et al. 2022

ecancer

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Background:The aim of this research was to characterise the interest on the most frequent cancers in Peru through Google Trends, its geographic and temporal relationship with massive awareness campaigns. Methods:A temporal trends analysis for the last 5 years was carried out, comparing the Relative Search Volume (RSV) with the dates of mass cancer awareness campaigns in Peru. Google Trends application was used to evaluate the interest in the topics: breast, prostate, cervical stomach and colorectal cancer between 1 January 2016 and 31 December 2020, expressed in RSV. The annual RSV for each neoplasm was compared, as well as its annual variation using the Kruskal-Wallis test. The correlation between the RSV and the estimated incidence for each province was measured using the Spearman test. Results:The topics with the highest RSV were breast (median: 20, range: 6-100) and prostate cancer (median: 28, range: 9-48). The topic 'breast cancer' showed a cyclical punctual increase in October, its awareness month. Searches for cervical, stomach and colorectal cancer were smaller and did not show peaks of interest. It was observed that the RSV was variable when compared with previous years (p < 0.05 for all the evaluated topics). Geographically, different provincial configurations of interest were observed according to neoplasia. When correlating the RSV with the incidence by province, a non-significant positive correlation (p > 0.05) was found for breast, cervical and colorectal cancer. Conclusions:This study suggests a positive temporal correlation between RSV and awareness cancer campaigns in Peru specially to breast cancer and, to a lesser extent, prostate cancer. Significant variations of interest were demonstrated for each neoplasm among the evaluated years. No significant correlation was found between the incidence rate and the average RSV among Peruvian provinces.

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“…Helicobacter pylori (Hp), a microaerobic Gram-negative bacteria, was first isolated from the gastric mucosa by Australian scholars Warren and Mashall in 1983. Hp is closely related to the occurrence of a variety of digestive diseases, which can lead to stomach cancer, gastric mucosarelated lymphoma, whereupon the World Health Organization therefore identified it as a Class I carcinogen in 1994 [38]. The MIC90 and MIC50 of jaundice for 10 clinical Hp strains were 1.31mg/mL, 1.05mg/mL, and the MIC for multi-drug-resistant Hp strains was 25-200mg/mL [39,40].…”

Section: Helicobacter Pylorimentioning

confidence: 99%

Research Progress on Antibiosis Activity of Scutellaria Flavonoids

Qin¹,

Liu²,

Xie³

et al. 2021

Asian J Complement Altern Med

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Scutellariae (Huangqin) is a traditional medicine that is widely applied in China for the treatment of cold and fever, and nowadays research found that it can against pathogenic microorganism. Flavonoids is the main active constituent isolated from Scutellariae and possesses outstanding antibiosis activity. Scutellaria flavonoids displayed antiseptic actions and anti-resistance, including but not limited to destroy bacterial biofilm, suppressed activity of the DNA enzyme, restrain efflux pump and quorum-sensing system. This paper highlights and discusses the antibiosis activity of Scutellaria flavonoids, along with possible mechanisms of its action. hoping to providing basis and evidence for clinical application.

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Helicobacter pylori: History and facts in Peru

Cited by 12 publications

References 83 publications

Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles

Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles

Impact of cancer awareness campaigns in Peru: a 5-year Google Trends analysis

Research Progress on Antibiosis Activity of Scutellaria Flavonoids

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