Helicobacter pylori in Cholecystectomy Specimens- Morphological and Immunohistochemical Assessment

Patnayak, Rashmi; Reddy, Venkatarami; Jena, Amitabh; Gavini, Siva; Asha, T.; Rukamangadha, Nandyala; Chowhan, Amit Kumar

doi:10.7860/jcdr/2016/14802.7716

Cited by 7 publications

(7 citation statements)

References 15 publications

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“…In contrast to many studies, a retrospective study 15 of 45 cases including cholecystectomy samples detected H. pylori -positivity in the gallbladder in 40% of patients without gallstones and 20% of those with gallstones. However, this difference was not significant and no relationship could be established between H. pylori -positivity and the occurrence of gallstones.…”

Section: Discussioncontrasting

confidence: 65%

Section: Discussionsupporting

confidence: 56%

“…Moreover, no H. pylori gallbladder infection was noted in 10 patients with ulceration of the gallbladder. 15 Similarly, the current study found no relationship between H. pylori-positivity in the gallbladder and gallstones, or the development of cholesterolosis, intestinal metaplasia, pyloric metaplasia, and activation. Previous studies reported that H. pylori was more prevalent in eastern countries and showed no sex difference, but was related to age, with a particular increase in colonization rates above the age of 70 years.…”

Section: Discussionsupporting

confidence: 56%

“…Many recent studies have investigated the occurrence of H. pylori outside the stomach, e.g., in the skin, nose, and gallbladder, 9,15 while other studies have evaluated the statuses of other Helicobacter strains within the gallbladder. 10,11 Fatemi et al compared Helicobacter strains between patients without gallstones and those with acute cholecystitis and chronic cholecystitis associated with gallstones.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between Helicobacter pylori-positivity in the gallbladder and stomach and effect on gallbladder pathologies

Arı¹,

Tatar²,

Yarıkkaya³

2019

J Int Med Res

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ObjectiveHelicobacter pylori commonly occurs in the stomach, but localizations outside the stomach and related diseases have also been investigated. However, the relationship between H. pylori and gallstones remains controversial. We aimed to investigate the relationships between H. pylori in the stomach and the gallbladder and gallstones.MethodsThis prospective case-control study included patients who underwent cholecystectomy because of gallstones, pancreatic head cancer, or hepatic resection. The patients were separated into two groups according to the detection of H. pylori in gallbladder samples using Giemsa staining. Stomach H. pylori status was based on previous gastroscopy.ResultsThe study enrolled 60 patients, comprising 27 patients with gallstones and 33 without. There was no significant difference in the incidence of gallstones between patients with or without H. pylori in the stomach or gallbladder. Furthermore, the presence of H. pylori in the stomach was measured in 14 patients and was significantly correlated with H. pylori in the gallbladder.ConclusionThe current study showed no relationship between the occurrence of gallstones and the presence of H. pylori in either the gallbladder or the stomach. In contrast to previous reports, this suggests that H. pylori does not play a role in the development of gallstones.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionsupporting

confidence: 56%

Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Relationship between Helicobacter pylori-positivity in the gallbladder and stomach and effect on gallbladder pathologies

Arı¹,

Tatar²,

Yarıkkaya³

2019

J Int Med Res

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“…This gram-negative rod has previously been associated with gastritis and acid peptic disease 8 for decades and studies have been carried out to show its association with gallstones, cholecystitis 13,14 and gall bladder cancer. 15 Many serological and histological methods 16,17 have been used to detect its presence in gall bladder mucosa and bile including Giemsa staining, H&E, PCR, Urease test, Warthin-starry 18 test etc. Out of these Giemsa and H&E are considered the simplest, cheapest and most specific methods.…”

Section: Original Articlementioning

confidence: 99%

Association of Clinicopathological features of cholecystitis with H.pylori infection in Gall bladders

Jimdc¹,

Mushtaq²

2019

JIMDC

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Background: Since H pylori has been mostly associated with gastritis its presence in other parts of gastrointestinal system has not been studied much. Few previous studies have identified “H pylori” in gallbladder and found its association in causing cholecystitis and gallstones but only a few studies have been performed in Pakistan that have shown a significant association. Therefore, in this study we looked for the presence of this microorganism in cholecystitis patients and its association with the morphological changes seen in gall bladders. Material and method: All patients with acute and chronic cholecystitis admitted in ANTH between the ages of 18 and 75 years from January 2017 till March 2019, who underwent cholecystectomy, were included in the study. Gall bladder specimens after surgery were sent to Pathology department ANTH and specimens were analyzed for the presence of H pylori bacteria using H&E and Giemsa staining. Signs of inflammation, any hyperplasia, metaplasia, mucosal atrophy or erosion, lymphoid infiltration, fibrosis, cholesterolosis or any other morphological changes were also noted. Association of H.pylori with cholecystitis and other morphological changes were checked by Chi Square analysis. P. value less than 0.05 was considered statistically significant Results: Chronic cholecystitis was present in 91% cases and acute cholecystitis in 9%. Other histological findings were Hyperplasia (10%), Metaplasia (15%), Fibrosis (79%), Cholesterolosis (19%) and ulcerations (36%). H pylori was found in 17% of gall bladders and all the cases were of chronic cholecystitis. Among these, there were 11.7% Males and 88% Females. Gallstones were present in 76.4% cases and age group involvement was seen more among 41-60 years (64.7%). Other histological findings seen in hpylori positive cases were; Hyperplasia in 11.7% cases, Metaplasia in 17.6%, Fibrosis in 94.1%, cholesterolosis in 23.5% and ulcerations in 17.6% cases. Association of H-Pylori with gender, cholecystitis, gall stones, histological features and age distribution was non-significant. Conclusion: Although H pylori infection has been found in cases of chronic cholecystitis and gall stone formation, its association with cholecystitis and other morphological changes could not be proved. Hence, it is uncertain whether H pylori eradication in patients with gastritis can prevent cholecystitis or gall stones formation

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The link between Helicobacter pylori infection and gallbladder and biliary tract diseases: A review

Lim

Lee

Jiang

et al. 2023

Ann Hepatobiliary Pancreat Surg

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Helicobacter pylori is a gram-negative pathogen commonly associated with peptic ulcer disease and gastric cancer. H. pylori infection has also been reported in cholelithiasis, cholecystitis, gallbladder polyps, and biliary tract cancers. However, the association between H. pylori and gallbladder and biliary tract pathologies remains unclear due to the paucity of literature. In response to the current literature gap, we aim to review and provide an updated summary of the association between H. pylori with gallbladder and biliary tract diseases and its impact on their clinical management. Relevant peer-reviewed studies were retrieved from Medline, PubMed, Embase, and Cochrane databases. We found that H. pylori infection was associated with cholelithiasis, chronic cholecystitis, biliary tract cancer, primary sclerosing cholangitis, and primary biliary cholangitis but not with gallbladder polyps. While causal links have been reported, prospective longitudinal studies are required to conclude the association between H. pylori and gallbladder pathologies. Clinicians should be aware of the implications that H. pylori infection has on the management of these diseases.

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Helicobacter pylori in Cholecystectomy Specimens- Morphological and Immunohistochemical Assessment

Cited by 7 publications

References 15 publications

Relationship between Helicobacter pylori-positivity in the gallbladder and stomach and effect on gallbladder pathologies

Relationship between Helicobacter pylori-positivity in the gallbladder and stomach and effect on gallbladder pathologies

Association of Clinicopathological features of cholecystitis with H.pylori infection in Gall bladders

The link between Helicobacter pylori infection and gallbladder and biliary tract diseases: A review

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