Helicobacter pylori in Gastric Malignancies

Bhandari, Abhishek; Crowe, Sheila E.

doi:10.1007/s11894-012-0296-y

Cited by 41 publications

(22 citation statements)

References 65 publications

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“…CagA H. pylori strains play a role in gastroduodenal ulcers and the development of gastric cancer. H. pylori infection was recently demonstrated to protect against gastro-oesophageal reflux disease and reflux esophagitis [6], to be associated with several extragastric disorders [7] and to play a role in respiratory disorders, such as chronic bronchitis and lung cancer [4,8,9]. A protective function in bronchial asthma, rhinitis and T-helper cell type 2 (Th-2) driven disorders in general has been proposed [10].…”

mentioning

confidence: 99%

Helicobacter pyloriseroprevalence in patients with idiopathic pulmonary fibrosis

et al. 2013

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confidence: 99%

Helicobacter pyloriseroprevalence in patients with idiopathic pulmonary fibrosis

et al. 2013

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“…In cancer patients, there is a deregulation of angiogenesis, with increased VEGF and decreased TSP1, promoting tumor angiogenesis and inflammation [22]. Hypermethylation of this gene has been found in many human primary cancers including gastric carcinoma and colorectal cancer [23,24]. Our results demonstrated that 5 % of GC samples were methylated within THBS1 gene promoter and 7 % in samples of normal tissue.…”

Section: Discussionmentioning

confidence: 57%

Association of COX2 gene hypomethylation with intestinal type gastric cancer in samples of patients from northern Brazil

et al. 2013

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To verify the methylation status of THBS1, GPX3, and COX2 genes and to evaluate their association with Helicobacter pylori in gastric adenocarcinomas. Methylation-sensitive restriction enzyme PCR assay was performed in 16 diffuse type gastric cancer samples, 23 intestinal type, and 15 normal stomach tissue. The presence of H. pylori was performed by amplification of the fragment of the 16S rRNA. Statistical analyses were performed using Fisher's exact test. The hypermethylation of GPX3, THBS1, and COX2 occurred in 18 (n = 7), 5 (n = 2), and 36 % (n = 14) of gastric cancer samples, respectively, whereas in normal samples, it was found in 13, 7, and 67 %. The presence of H. pylori was detected in 67 % of gastric cancer samples and 67 % in normal gastric samples. The methylation of THBS1 and GPX3 was not significantly different between the types of tumors, normal sample, the presence of H. pylori, or clinicopathological variables studied (P > 0.05). However, the methylation status of the gene COX2 is significantly different between normal tissue and intestinal type gastric cancer (P = 0.02). Therefore, our results suggest that the methylation status of the gene COX2 is associated with the intestinal type of gastric cancer.

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“…Although it was reported that there was no difference in H. pylori seroprevalence between majorities of intestinal and diffuse types of cancer cases, there were also studies in which significantly higher rates were defined in intestinal type (80-90%) than the diffuse type (30%) cancer cases (Bhandari and Crowe, 2012).…”

Section: Discussionmentioning

confidence: 95%

Is Helicobacter pylori a Poor Prognostic Factor for HER-2 SISH Positive Gastric Cancer?

Selçukbiricik

Tural²,

Erdamar³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Helicobacter pylori (H. pylori) is one of the risk factors for gastric cancer (GC). Any prognostic effect of HER-2 status in gastric lymph node metastasis in H. pylori positive cases is unknown. Materials and Methods: A total of 74 patients, 47 (64%) male, and 27 (34%) female, who had subtotal or total gastrectomy and also positive lymph nodes, were included in the study. Age range was 29-87 years, and median age was 58 years. HER-2 expression was assessed in both gastric resection samples and lymph node material with carcinoma metastasis of the same patient by immunohistochemistry (IHC) and silver in situ hybridization (SISH) methods. H. pylori status was examined in gastric materials of all patients. Relationships between HER-2 status in gastric cancers and lymph nodes and H. pylori status were investigated. Results: H. pylori was positive in 40 cases (54%), and negative in 34 (46%). While in the primary tissues of H. pylori positive cases, SISH positivity for HER-2 was observed in 13 cases (86%), SISH negativity was observed in 2 (14%), in metastatic lymph nodes 21 cases (72%) were SISH positive and 8 cases (28%) were SISH negative (P=0.005 and P=0.019, respectively). Initial CEA values were high in 18 cases (78%) with positive H. pylori and in 5 cases (22%) with negative H. pylori (P=0.009). While SISH data of patients were negative in 59 cases (80%) and positive in 15 cases (20%) in primary tissues, they were negative in 56 cases (75%) and positive in 18 cases (25%) in lymph nodes. Discrepancy between primary tissue and lymph node results was detected in 3 cases, in which SISH was negative in the primary tissue and HER-2 expression was positive in the lymph nodes. Conclusions: Clinical progression was poor in H. pylori positive cases with HER-2 negativity in primary gastric tissue, but HER-2 positivity in the lymph nodes. SISH positivity can be expected in H. pylori positive cases, and it may be predicted that these cases can benefit from trastuzumab treatment.

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Helicobacter pylori in Gastric Malignancies

Cited by 41 publications

References 65 publications

Helicobacter pyloriseroprevalence in patients with idiopathic pulmonary fibrosis

Helicobacter pyloriseroprevalence in patients with idiopathic pulmonary fibrosis

Association of COX2 gene hypomethylation with intestinal type gastric cancer in samples of patients from northern Brazil

Is Helicobacter pylori a Poor Prognostic Factor for HER-2 SISH Positive Gastric Cancer?

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