Helicobacter pylori in sedentary men is linked to higher heart rate, sympathetic activity, and insulin resistance but not inflammation or oxidative stress

Abstract

AimTo compare anthropometric parameters, body composition, hormonal and inflammatory profiles, oxidative stress indices, and heart rate variability (HRV) in Heliobacter pylori (H.pylori) positive and negative healthy sedentary participants.MethodsAmong 30 recruited apparently healthy male participants (age between 20 and 40) enrolled in this cross-sectional study, 18 were H.pylori negative and 12 were positive (stool antigen test). Participants underwent routine physical examination and body composition determination. The following biochemical parameters were determined in blood: fasting whole blood glucose, glycated hemoglobin, insulin, C-peptide, cortisol, aldosterone, testosterone, thyroid stimulating hormone, C-reactive protein, interleukins 6 and 10, tumor necrosis factor-α, and the urinary level of 1,4-dihydroxynonane mercapturic acid. For HRV evaluation, electrocardiogram in supine position and in orthostatic test was performed.ResultsH.pylori contamination was not significantly associated with any changes in anthropometric parameters, body composition, blood pressure, fasting glucose, or glycated hemoglobin levels. No significant difference was found for inflammatory markers as well as 1,4-dihydroxynonane mercapturic acid. H.pylori-positive participants, however, had significantly higher heart rate (P = 0.009), sympathetic/parasympathetic balance in orthostatic test (P = 0.029), fasting insulin level (P = 0.037), and HOMA-index (P = 0.047).ConclusionsH.pylori contamination is linked to a significantly higher heart rate, sympathetic activation, and increased insulin resistance, while inflammatory and oxidative stress markers remain unaffected in healthy sedentary male subjects.

Glucose as a Major Antioxidant: When, What for and Why It Fails?

“…The opposite effects are mediated by anti-inflammatory interleukin-10 [104] and the spleen plays a particularly important role in these regulatory interactions [105]. The autonomic nervous system may also be involved in regulation of interactions of local inflammatory conditions and oxidative stress [106]. Autonomic output is actively involved in the regulation of glucose homeostasis and can adjust the rates of glucose production and utilization independently of hormonal influences [107].…”

Helicobacter pylori in Health and Disease: Its Contribution to Gastrointestinal Disorders and Systemic Metabolic Effects

“…It was demonstrated that Amaranth oil supplementation provided significant improvement of gastric mucosa morphological pattern and also had a positive effect on heart rate variability [5]. In a separate study we demonstrated that H. pylori in apparently healthy sedentary young male subjects is associated with higher heart rate, sympathetic activity and insulin resistance, however, we detected no changes in parameters reflecting inflammatory profile, metabolic parameters or oxidative stress [6][7][8]. In summary, there is a growing evidence of systemic metabolic effects of H. pylori infection not only in patients with overt gastrointestinal disorders, but also in apparently asymptomatic healthy subjects.…”

Glucose as a Major Antioxidant: When, What for and Why It Fails?

“…The opposite effects are mediated by anti-inflammatory interleukin-10 [104] and the spleen plays a particularly important role in these regulatory interactions [105]. The autonomic nervous system may also be involved in regulation of interactions of local inflammatory conditions and oxidative stress [106]. Autonomic output is actively involved in regulation of glucose homeostasis and can adjust the rates of glucose production and utilization independently of hormonal influences [107].…”