2012
DOI: 10.1111/j.1477-2574.2011.00423.x
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Helicobacter pylori in Thai patients with cholangiocarcinoma and its association with biliary inflammation and proliferation

Abstract: The present findings suggest that H. pylori, especially the cagA-positive strains, may be involved in the pathogenesis of hepatobiliary diseases, especially CCA through enhanced biliary cell inflammation and proliferation.

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Cited by 63 publications
(100 citation statements)
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“…Previous study reported that H. pylori or related similar H. pylori could be detected in liver tissues from patients with cholestatic liver diseases [21]. In agreement with our previous report, we demonstrated that H. pylori was found significantly in patients with CCA compared to a cholelithiasis and control groups [4]. Additionally, our previous study found that the presence of H. pylori in CCA patients was associated with biliary cell inflammation and proliferation, as determined via inflammatory grading and Ki67-labelling immunohistochemistry techniques, respectively [4].…”
Section: Discussionsupporting
confidence: 92%
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“…Previous study reported that H. pylori or related similar H. pylori could be detected in liver tissues from patients with cholestatic liver diseases [21]. In agreement with our previous report, we demonstrated that H. pylori was found significantly in patients with CCA compared to a cholelithiasis and control groups [4]. Additionally, our previous study found that the presence of H. pylori in CCA patients was associated with biliary cell inflammation and proliferation, as determined via inflammatory grading and Ki67-labelling immunohistochemistry techniques, respectively [4].…”
Section: Discussionsupporting
confidence: 92%
“…pylori genomic DNA was extracted from bile and gastric tissue samples. DNA extractions from bile samples were previously described by Boonyanugomol et al [4]. The DNA samples from biopsies positive for RUT were extracted using a genomic DNA extraction and purification kit (Gentra System, Inc., Minneapolis, USA), according to the manufacturer's instructions.…”
Section: Dna Extractionmentioning
confidence: 99%
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“…H. bilis causes similar pre-malignant pathological changes to those seen in liver fluke infection in the biliary tree in an animal model (chronic hepatitis, hepatic dysplasia, fibrosis, and biliary hyperplasia) (70) . Cell inflammation and proliferation of biliary and gallbladder epithelial cells has been shown to be significantly higher in O. viverrini-related cholangiocarcinoma with H. pylori DNA detected in bile samples, compared to those without detectable biliary H. pylori infection (71) . The increased inflammatory and proliferative process in these patients was more pronounced in biliary infections with H. pylori harbouring the cagA gene (71) , an important virulence factor known to induce the severe inflammation associated with gastric adenocarcinoma (72) .…”
Section: Cholangiocarcinomamentioning
confidence: 99%
“…Cell inflammation and proliferation of biliary and gallbladder epithelial cells has been shown to be significantly higher in O. viverrini-related cholangiocarcinoma with H. pylori DNA detected in bile samples, compared to those without detectable biliary H. pylori infection (71) . The increased inflammatory and proliferative process in these patients was more pronounced in biliary infections with H. pylori harbouring the cagA gene (71) , an important virulence factor known to induce the severe inflammation associated with gastric adenocarcinoma (72) . H. bilis and H. pylori infection is associated with cholangiocarcinoma in patients in both areas endemic for human liver fluke infection and in areas where human liver fluke infection is rarely seen (73)(74)(75) .…”
Section: Cholangiocarcinomamentioning
confidence: 99%