Helicobacter pylori infection: A balance between bacteria and host

Bucci, Pamela; Barbaglia, Yanina; Tedeschi, F; Zalazar, Fabián

doi:10.1016/j.ram.2022.04.003

Cited by 5 publications

(6 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…48 The cytotoxin-associated gene product (CagA), the vacuolating toxin (VacA), and the adhesion protein BabA2 are three of the major virulent factors of H. pylori. [49][50][51] Studies from Brazil, Saudi, Mexico, Japan, and Laos showed that the three virulent factors might be meaningful markers of the toxicity of H. pylori and clinical outcome of patients. [52][53][54][55][56] Combination detection of serum pepsinogen I, pepsinogen II, gastrin-17, and H. pylori virulent factors might improve the precise prediction of high-risk subpopulation of gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Prevalence Difference of Helicobacter pylori Infection Between Tibetan and Han Ethnics in China: A Meta-analysis on Epidemiologic Studies (SIGES)

Bai

Wang

et al. 2022

Asia Pac J Public Health

View full text Add to dashboard Cite

China is a multi-ethnic country, and the prevalence of Helicobacter pylori ( H pylori) infection may be diverse among ethnics. This meta-analysis was conducted to compare the prevalence of H pylori infection between Tibetans and Han ethnics. Ten studies that reported the prevalence of H pylori infection between Tibetans and Hans in China were eligible. The pooled prevalence of H pylori infection was 62.2% versus 55.3% among Tibetans and Hans, respectively. Tibetans had a higher risk of H pylori infection than Hans (odds ratio [OR] = 1.38, 95% confidence interval [CI] [1.05, 1.80]). In subgroup analysis, Tibetans with upper gastrointestinal symptoms (OR = 1.51, 95% CI [1.06-2.16]), inhabiting in Tibet (OR = 1.51, 95% CI [1.22, 1.87]), or inhabiting in Northwestern region (OR = 1.15, 95% CI [1.00, 1.31]) had significantly higher risks of H pylori infection. In addition, in the recent 10 years, Hans showed a decreased risk of H pylori infection (OR = 1.81, 95% CI [1.42, 2.30]). Heterogeneity was common, while sensitivity analyses showed partially inconsistent results against main findings. This study demonstrated higher prevalence of H pylori infection in Tibetans compared with Hans, especially in recent years, or in Tibet and northwest China, as well as symptomatic Tibetans. The results suggest tailored strategy and robustness need to be further considered for H pylori screening and eradication among Tibetans.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence Difference of Helicobacter pylori Infection Between Tibetan and Han Ethnics in China: A Meta-analysis on Epidemiologic Studies (SIGES)

Bai

Wang

et al. 2022

Asia Pac J Public Health

View full text Add to dashboard Cite

show abstract

“…Similarly, OMVs can also be released by harmful bacteria, such as the Gram-negative proteobacterium Helicobacter pylorus (Hp), whose chronic infection leads to chronic inflammation and the development of gastric cancer [ 152 , 153 ]. Hp OMVs have been shown to carry virulence genes (CagA and VacA) of the parent bacteria, which can induce the production of immunomodulatory cytokines in host macrophages and gastric epithelial cells [ 154 , 155 ]. As seen from in vitro and in vivo studies, Cy7 labeled Hp OMVs were able to infiltrate the gastric epithelium and still be detectable even 24 h after injection, causing inflammation and contributing to the development of gastric cancer [ 156 ].…”

Section: Biology Of Extracellular Vesiclesmentioning

confidence: 99%

Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery

Al-Jipouri,

Eritja,

Bozic

2023

IJMS

View full text Add to dashboard Cite

Extracellular vesicles (EVs) are nanoparticles released from various cell types that have emerged as powerful new therapeutic option for a variety of diseases. EVs are involved in the transmission of biological signals between cells and in the regulation of a variety of biological processes, highlighting them as potential novel targets/platforms for therapeutics intervention and/or delivery. Therefore, it is necessary to investigate new aspects of EVs’ biogenesis, biodistribution, metabolism, and excretion as well as safety/compatibility of both unmodified and engineered EVs upon administration in different pharmaceutical dosage forms and delivery systems. In this review, we summarize the current knowledge of essential physiological and pathological roles of EVs in different organs and organ systems. We provide an overview regarding application of EVs as therapeutic targets, therapeutics, and drug delivery platforms. We also explore various approaches implemented over the years to improve the dosage of specific EV products for different administration routes.

show abstract

“…As previously noted, the majority of patients infected with H. pylori exhibit histologic gastritis, and the phenotype of this gastritis will influence the progression of symptoms [48][49][50]. Most of the patients have a mild gastritis phenotype that in general is asymptomatic and do not affect the acid secretion, 10 to 15% presents the duodenal ulcer phenotype that affects the secretory function with a higher production of gastrin and acid secretion, with disturbances in the inhibitory control of acid secretion leading to dyspeptic symptoms and/or duodenal ulcer, and less than 1% present the gastric cancer phenotype that culminates in a strong reduction or absence of acid secretion, leading to severe atrophic gastritis, intestinal metaplasia and gastric cancer [21,34,[51][52][53]. In Figure 2 the treatment and strain genetic mutations have been determined and described in literature [58,59].…”

Section: Introductionmentioning

confidence: 99%

Bioactive peptides as alternative treatment for Helicobacter pylori infection

Franca-Oliveira,

Hernández-Ledesma,

Martinez-Rodriguez

2024

BCHD

View full text Add to dashboard Cite

The infection and chronic inflammatory response generated by Helicobacter pylori is a global health concern. This pathogen is characterized as a major risk factor in the development of gastric cancer and other diseases. Conventional eradication therapies are based on antibiotic regimens and as a consequence there is an increase in antimicrobial resistance of the pathogen strains, besides other potential side effects for the host. Therefore, it is necessary to explore new alternatives. This review delves into the realm of antimicrobial peptides, exploring their efficacy against H. pylori sourced from diverse origins. Furthermore, it sheds light on food-derived peptides exhibiting remarkable biological activity. These peptides exhibit promising effects on biomarkers associated with H. pylori infection, demonstrating anti-inflammatory and antioxidant properties validated through rigorous testing in both cell and animal models. Regarding the anti-inflammatory activity, the peptide VPY derived from soybean and the peptides derived from animal sources such as meat (β-Ala-His), egg (DEDTQAMPFR, DEDTQAMPF, MLGATSL, MSYSAGF, CR, FL, HC, LL, MK) and milk (IPAV) have reported a reduction of the cytokine IL-8, biomarker directly related to H. infection. For the antioxidant activity, peptides derived from milk (EAMAPK, AVPYPQ) and from Spirulina maxima (LDAVNR, MMLDF) have reduced ROS levels and could have a positive effect on the control of H. infection. Food-derived bioactive peptides with an anti-adhesive effect were also discussed. They derive from vegetable sources (corn, pea and wheat) and are capable of interacting with the host cells, interfering the adherence of H. pylori. Food-derived bioactive peptides have potential to avoid and/or mitigate undesired outcomes of infectious diseases due to the possibility of its application in nutraceuticals and food products, resulting in a preventive approach. Keywords: Helicobacter pylori, antibiotic resistance, bioactive peptides, antimicrobial peptides

show abstract

Helicobacter pylori infection: A balance between bacteria and host

Cited by 5 publications

References 41 publications

Prevalence Difference of Helicobacter pylori Infection Between Tibetan and Han Ethnics in China: A Meta-analysis on Epidemiologic Studies (SIGES)

Prevalence Difference of Helicobacter pylori Infection Between Tibetan and Han Ethnics in China: A Meta-analysis on Epidemiologic Studies (SIGES)

Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery

Bioactive peptides as alternative treatment for Helicobacter pylori infection

Contact Info

Product

Resources

About