Helicobacter pylori Infection Aggravates Dysbiosis of Gut Microbiome in Children With Gastritis

Abstract

Introduction: Helicobacter pylori infection consistently leads to chronic and low degree of inflammatory response in gastric mucosa and is closely related with gastrointestinal and extra-gastric diseases. Effects of local microbiome in the stomach have been studied in adults and children with H. pylori infection. It is, however, not known whether the intestinal microbial community differs in children with varying H. pylori infection. The aim of this study is to characterize the altered composition of microbiome induced by H. pylori infection and in gastritis.Materials and Methods: This study involved 154 individuals, including 50 children affected by H. pylori-induced gastritis, 42 children with H. pylori-negative gastritis, and 62 healthy controls. Gut microbiome composition was analyzed using 16S rRNA gene-based pyrosequencing. Fecal bacterial diversity and composition were then compared.Results: On the basis of an analysis of similarities and differences, we found that children with H. pylori-induced gastritis exhibited gut bacteria dysbiosis. The ratio of Firmicutes/Bacteroidetes (F:B) at the phylum level had dramatically decreased in H. pylori-positive gastritis group (HPG) and H. pylori-negative gastritis group (HNG), compared with the healthy control group (HCG). At the family and genus levels, relative abundance of Bacteroidaceae and Enterobacteriaceae was prevalent in HPG and HNG, whereas relative abundance of Lachnospiraceae, Bifidobacteriaceae, and Lactobacillaceae was seen in HCG. Prevalence of different taxa of gut microbiome at the class, order, family, and genus levels was also observed among the three groups.Conclusions: Gastritis can cause changes in composition of fecal microbiome, which is exacerbated by H. pylori infection. These changes in gut microbiome may be related to drug resistance and development of chronic gastrointestinal diseases.

Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice

“…The major bacterial genera were Prevotella, Helicobacter, Clostridium, Oscillospira, Bacteroides, Lactobacillus, Ruminococcus and Sutterella. Helicobacter infection aggravates dysbiosis of gut microbiome [47]. It was found in our study that in model group Helicobacter was increased significantly after D-gal injection compared to NC group.…”

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

“…The other topic which deserves more attention is HPI-associated dysregulation of gut microbiota [ 239 , 606 , 653 , 654 , 655 , 656 , 657 , 658 , 659 , 660 , 661 , 662 , 663 , 664 , 665 , 666 , 667 ], a phenomenon described also in animal models (infected Mongolian gerbils [ 668 ]) and thought to be due mainly to gut immunopathological/inflammatory responses and suppressed gastric acid secretion following chronic/atrophic gastritis or use of acid-suppressive drugs. Gut dysbiosis by affecting various biological processes contributes to the pathogenesis of OP [ 669 , 670 , 671 , 672 , 673 , 674 , 675 , 676 , 677 , 678 , 679 , 680 , 681 , 682 , 683 , 684 , 685 , 686 , 687 , 688 , 689 , 690 , 691 , 692 , 693 , 694 , 695 , 696 , 697 , 698 , 699 ] as well as to numerous other extra-digestive system diseases associated with OFs [ 700 , 701 , 702 ,…”

Chronic gastroduodenal pathology in schoolchildren: the clinical picture and features of the course

“…Заболевание только у небольшой доли пациентов развивалось клиническим проявлением хронической инфекции, например, развитием ЯБЖ и рака желудка [12]. Аналогичного мнения придерживаются Yang L et al, 2019, считая, что H.pylori инфицированность проявляется в более позднем возрастном периоде, хотя преимущественно пациенты поражаются в более молодом возрасте [13]. Хотя, как утверждают, М. А. Казакова с соавторами, 2016, у H.pylori инфицированных детей, клиническая симптоматика хронического гастродуоденита отличается полиморфизмом, и в первую очередь эта касается диспепсических нарушений и болевого синдрома [7].…”

“…При рассмотрении течения ХГДП в зависимости от возраста было отмечено, что с возрастом наблюдается снижение субъективных признаков патологии. В частности, у пациентов доподросткового возраста (6-11 лет), n=145 (50,7% из 286), у 113 (77,9% из 145) отмечали наличие нарушение сна и у 118 (81,4% из 145) периодические головные боли, в то врем как у пациентов подросткового возраста (11)(12)(13)(14)(15)…”