Helicobacter pylori infection and adenocarcinoma arising in Barrett's esophagus

Quddus, M. Ruhul; Henley, John; Sulaiman, Raed; Palumbo, Theodore C; Gnepp, Douglas R.

doi:10.1016/s0046-8177(97)90052-6

Cited by 32 publications

(19 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…58 -60 An inverse association between H. pylori infection and the presence of Barrett esophagus has also been found. [61][62][63][64] It is thus possible that certain types of H. pylori infection may promote noncardia gastric adenocarcinoma development but may protect against the development of Barrett esophagus and the Barrett-associated adenocarcinomas of the esophagus and cardia.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of p53 Mutations in Adenocarcinoma of the Esophagus and Cardia

Ireland

Shibata²,

Chandrasoma³

et al. 2000

Annals of Surgery

View full text Add to dashboard Cite

ObjectiveTo compare the frequency and spectrum of p53 gene mutations in adenocarcinomas of the esophagus and cardia and to compare clinical and pathologic features in patients with p53 mutant and nonmutant cancers. Summary Background DataThe p53 gene is commonly mutated in human cancers, and a p53 mutation is reported to be present in more than 50% of esophageal adenocarcinomas. Although many studies have investigated the frequency of p53 protein overexpression in adenocarcinomas of the esophagus or esophagogastric junction, few studies have assessed the frequency and clinical significance of p53 mutations in these tumors. In particular, the prognostic importance of p53 mutation is uncertain. Adenocarcinomas of the esophagus and cardia share many epidemiologic and pathologic features, but it is controversial whether they represent the same tumor. A comparison of the frequency and spectrum of mutations in adenocarcinomas of the esophagus and cardia would test whether these tumors are also similar at the molecular level. MethodsDNA was isolated from microdissected paraffin-embedded tumor tissues of patients who underwent esophagogastrectomy for adenocarcinoma of the esophagus (n ϭ 19), cardia (esophagogastric junction, n ϭ 12), or subcardia (n ϭ 6). Exons 5 to 8 of the p53 gene were analyzed for the presence of mutations using the polymerase chain reaction with singlestrand conformation polymorphism and DNA sequencing of bands showing abnormal mobility. The presence of mutation was confirmed by selective hybridization of a mutant-specific oligonucleotide to DNA isolated from the tumor. Resultsp53 mutations were identified in 18 of 37 (48.6%) tumors. Patients with p53 mutant tumors were significantly younger and had a significantly poorer prognosis. There was a similar prevalence of p53 mutations in adenocarcinomas of the esophagus (53%) and cardia (58%). In contrast, mutations were relatively uncommon in subcardia adenocarcinomas (one mutant tumor [17%]). The types of mutations found in the esophageal and the cardia cancers were also similar.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Significance of p53 Mutations in Adenocarcinoma of the Esophagus and Cardia

Ireland

Shibata²,

Chandrasoma³

et al. 2000

Annals of Surgery

View full text Add to dashboard Cite

show abstract

“…HP has been shown to colonize Barrett's epithelium, although one study identified no organisms sion and iron deficiency [39]. In another study, however, there was no association between either cigarette smoking in a series of biopsies from Barrett's mucosa, dysplasia, and cancers of the esophagus [44]. Published data do or alcohol use and EGJ adenocarcinoma [40].…”

Section: Etiology and Risk Factorsmentioning

confidence: 98%

Adenocarcinoma of the Esophagogastric Junction

Jenkins

1999

Dig Dis

View full text Add to dashboard Cite

Adenocarcinoma of the esophagogastric junction (EGJ) has increased rapidly in incidence in the latter half of the twentieth century. The increase in incidence has affected white men between the ages of 40 and 60 disproportionately. Understanding the etiology and improving treatment requires careful classification of EGJ tumors. A recent consensus conference recognized three types of EGJ adenocarcinomas: distal esophageal, cardia, and subcardia gastric. Distal esophageal adenocarcinomas are associated with Barrett’s esophagus. Heilcobacter pylori infection may play a role in some adenocarcinomas of the subcardia, but the association is unproven. Therapy for all types of EGJ tumors is surgical, but multimodal forms of treatment are commonly used because of the advanced stage at which these tumors often present. Several endoscopic options exist for primary therapy of early-stage tumors and for palliation.

show abstract

“…Several studies have supported the protective effect of H. pylori infection against the development of GORD and BO [17][18][19][20], whereas other studies suggest that the presence of H. pylori infection does not alter the natural history of BO [21,22]. Moreover, one study suggested that neither gastric nor esophageal infection with H. pylori was required for the development of BO-related OA [23].…”

Section: Dear Editormentioning

confidence: 99%