Helicobacter pylori Infection and Diabetes Mellitus

Haj, Saeda; Raviv, Michal; Muhsen, Khitam

doi:10.5772/63826

Cited by 3 publications

(3 citation statements)

References 102 publications

(150 reference statements)

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“…The literature regarding the association between H. pylori and diabetes risk is inconsistent, with reports of positive, null and negative associations [4][5][6]. A published meta-analysis systematically reviewed the association between H. pylori Table 2 Association between H. pylori infection and risk of developing diabetes ( No., number Table 3 Association between persistent H. pylori infection and risk of developing diabetes No., number infection and diabetes based on observational studies and drew the conclusion that there was a trend toward more frequent H. pylori infection in individuals with diabetes [4].…”

Section: Discussionmentioning

confidence: 99%

“…An increasing number of studies have also revealed that H. pylori infection may have a wider ranging impact on health through its extragastrointestinal effects [3]. Specifically, this includes an association between H. pylori infection and diabetes [4][5][6], a harmful metabolic disease with rapidly increasing prevalence worldwide, particularly over the past 30 years [7].…”

Section: Introductionmentioning

confidence: 99%

“…These studies provided the preliminary pathophysiological evidence for the potential connection between H. pylori infection and diabetes risk. Several studies have reported direct evidence for the association between H. pylori infection and diabetes risk [4][5][6]. However, most of these studies were based on relatively small sample sizes using either a cross-sectional or casecontrol design, with inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

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The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study

Zhou

Liu

et al. 2017

Diabetologia

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Aims/hypothesis Previous studies have suggested a possible connection between Helicobacter pylori (H. pylori) infection and diabetes risk. However, prospective studies examining direct associations between these two factors are relatively lacking. In this prospective cohort study, we aimed to evaluate the association between H. pylori infection and risk of developing diabetes. Methods We performed a population-based prospective study, recruiting participants aged 45-74 years and without diabetes from the Chinese Multi-provincial Cohort Study in 2002, with a 10 year follow-up to investigate development of diabetes. H. pylori serostatus was determined by measuring serum H. pylori antibodies. H. pylori seropositivity was defined as the antibody concentration ≥ 10 U/ml. To examine the association between H. pylori seropositivity and diabetes risk, modified Poisson regression was performed. Results Of 2085 participants without diabetes, 1208 (57.9%) were H. pylori seropositive in 2002. After multivariate adjustment of possible diabetes risk factors, H. pylori seropositivity was associated with lower risk of diabetes (RR 0.78 [95% CI 0.63, 0.97], p = 0.022). Of the 1275 participants with H. pylori antibody measurements in both 2002 and 2007, 677 (53.1%) were persistently seropositive. A lower risk of diabetes was also observed in participants with persistent H. pylori seropositivity (RR 0.61 [95% CI 0.41, 0.93], p = 0.020), compared with those persistently seronegative. Conclusions/interpretation H. pylori seropositivity was associated with lower risk of diabetes in this prospective cohort study. Extrapolation of these results and the mechanism underlying the observed association require further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study

Zhou

Liu

et al. 2017

Diabetologia

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Relationships of H. pylori infection and its related gastroduodenal morbidity with metabolic syndrome: a large cross-sectional study

Refaeli

Chodick

Haj

et al. 2018

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The few published studies on the relationship between Helicobacter pylori infection and metabolic homeostasis were relatively small and yielded inconsistent results. We examined the prevalence of metabolic syndrome in relation to H. pylori infection and its symptoms in a large and unselected population. Coded data from the computerised database of a large health maintenance organisation in Israel were accessed for 147,936 individuals 25–95 years of age who performed the urea breath test during 2002–2012. The classification of metabolic syndrome followed a modified definition of the international diabetes federation. Prevalences of H. pylori infection and metabolic syndrome were 52.0% and 11.4% respectively. H. pylori infected patients had increased likelihood of metabolic syndrome: adjusted odds ratio (aOR) 1.15 (95% confidence intervals (CI) 1.10–1.19), as did patients with gastric ulcer: aOR 1.15 (95% CI 1.03–1.28) vs patients without these conditions. Duodenal ulcer was associated with metabolic syndrome only in persons aged 25–34 years: aOR 1.59 (95% CI 1.19-2.13), but not in older persons (P = 0.001 for heterogeneity). In conclusion, the likelihood of metabolic syndrome appeared significantly increased in relation to H. pylori infection and gastric and duodenal ulcers. These findings suggest that H. pylori long-term gastric inflammation might play a role in metabolic homeostasis.

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Differences in glycated hemoglobin levels and cholesterol levels in individuals with diabetes according to Helicobacter pylori infection

Haj

Chodick

Goren

et al. 2021

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This study examined differences in glycated hemoglobin (HbA1c), fasting plasma glucose and cholesterol levels between H. pylori infected and uninfected persons with diabetes. Anonymized data of Maccabi Healthcare Services in Israel were analyzed, of 12,207 individuals (50.0% H. pylori positive) aged 25–95 years who underwent the urea breath test. The data included HbA1c, fasting plasma glucose and cholesterol levels. The inverse probability of treatment weighting approach was used to account for confounders. Differences between individuals who were H. pylori positive and negative, in HbA1c (> or ≤ 7.0%) and in cholesterol levels were assessed using weighted generalized estimating equations. For men, but not women, the likelihood of having HbA1c > 7.0% was increased in those infected than uninfected with H. pylori: prevalence ratio 1.11 (95% CI 1.00, 1.24), P = 0.04. For both sexes, total cholesterol (P = 0.004) and low-density lipoprotein (LDL) levels (P = 0.006) were higher among those infected than uninfected with H. pylori. No significant differences were found in glucose and HDL levels according to H. pylori infection. The results were consistent in unweighted multivariable analyses. In conclusion, H. pylori infection might be related to worse glycemic control in men, and higher total cholesterol and LDL cholesterol levels in both sexes.

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Helicobacter pylori Infection and Diabetes Mellitus

Cited by 3 publications

References 102 publications

The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study

The association between Helicobacter pylori seropositivity and risk of new-onset diabetes: a prospective cohort study

Relationships of H. pylori infection and its related gastroduodenal morbidity with metabolic syndrome: a large cross-sectional study

Differences in glycated hemoglobin levels and cholesterol levels in individuals with diabetes according to Helicobacter pylori infection

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