Helicobacter pylori infection and its correlates among the patients of peptic perforation and gastric carcinoma

Saha, Subhendu Bikas; Bakshi, Sabyasachi; Mandal, Tapas K.

doi:10.21203/rs.3.rs-29536/v1

Cited by 1 publication

(2 citation statements)

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“…The present study found that around three-fourths of the patients were Hindus and 22.5% were Muslims and most of them were married (85%), which corresponds to the study done by Saha et al ,[ 11 ] which also reported most of the patients suffering from perforated ulcer were Hindus and married persons were the commonest. The beneficiaries of the studied hospital are mostly Hindus, and this has been reflected in the findings of the present study.…”

Section: Discussionsupporting

confidence: 90%

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Profile of gastroduodenal perforation patients admitted in a rural tertiary care hospital: An observational cross-sectional study

Bose,

Ray,

Ali

et al. 2024

JWAS

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Background: Gastro-duodenal perforation is a common surgical emergency that remains a formidable health burden worldwide with significant morbidity and mortality. Ulcer disease remains the most common cause of gastro-duodenal perforation. Diagnosing the presence of H. pylori can help eradicate the infection from the community at large and thereby reduce the chances of gastro-duodenal perforation. Aims: To assess the clinical presentation of gastro-duodenal perforation patients and to evaluate the detection of Helicobacter pylori infection by available investigations. Materials and Methods: A descriptive observational study was conducted among 80 patients presenting with clinical features suggestive of gastro-duodenal perforation and confirmed by clinical, radiological basis and operative findings admitted at a rural tertiary care hospital during 2019-2020. Detailed history was taken from the patient/party, clinically examined, and blood/tissue samples were investigated. The patients were managed with standard treatment modality in the studied institute. Data were collected, compiled, and entered MS Excel and analyzed using appropriate software. Descriptive analysis was done in the form of proportion for categorical variables, mean or median for continuous variables. Result: Cases of gastro-duodenal perforations were more among middle to later age of life, mostly affecting married male patients hailed from rural area and unskilled workers. History of intake of spicy food, prolonged starvation, history of NSAID use were common among them. Majority of the patients had history of pain abdomen in the past suggesting of PUD and history of taking variety group of acid reducing agents. Most of them presented with epigastric pain, vomiting, abdominal distension along with other signs of peritonitis. Obliteration of liver dullness and free gas under right dome of diaphragm was also noted in large proportion among them. Majority of cases were found positive for H. pylori on Histology (85%), followed by rapid urease test (RUT) (80%) and a positivity of 72.5% and 68.8% on serum IgG and IgA antibody respectively. Rapid Urease Test was more sensitive as well as specific in diagnosing of H. pylori than antibody detection test. Conclusion: Early detection of H. pylori infection and treatment with potent anti H. pylori therapy postoperatively has been found to be adequate.

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Section: Discussionsupporting

confidence: 90%

“…In a study by Saha et al [ 11 ] observed that RUT, an indicator of H. pylori infection, was positive in 82% patients of with peptic perforation. The present study has reported almost a similar result (80%).…”

Section: Discussionmentioning

confidence: 99%