Helicobacter pylori Infection and Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Heydari, Keyvan; Yousefi, Mohammad; Alizadeh‐Navaei, Reza; Lotfi, Parisa; Sheydaee, Fateme; Raei, Maedeh; Vahdatinia, Alireza; Hessami, Amirhossein; Rafati, Sajjad; Moosazadeh, Mahmood; Ghasemian, Roya; Salehi, Fatemeh; Massoudi, Haleh; Ghaffari-Saravi, Fatemeh; Rismantab, Sahar

doi:10.5152/tjg.2022.21467

Cited by 13 publications

(9 citation statements)

References 46 publications

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“…Based on the data from cohort studies, H. pylori infection increased the risk of NAFLD occurrence after adjustment for confounders. Notably, seven previous metaanalyses [51][52][53][54][55][56][57] also concluded a signifcant association between H. pylori infection with NAFLD. Our current metaanalysis has several advantages compared to previous ones [51][52][53][54][55][56][57].…”

Section: Discussionmentioning

confidence: 98%

“…Notably, seven previous metaanalyses [51][52][53][54][55][56][57] also concluded a signifcant association between H. pylori infection with NAFLD. Our current metaanalysis has several advantages compared to previous ones [51][52][53][54][55][56][57]. First, there was a more comprehensive collection of eligible studies by expanding the search strategy and updating the fnal search date.…”

Section: Discussionmentioning

confidence: 98%

“…Second, some of the previous meta-analyses did not strictly follow the prespecified inclusion and exclusion criteria to collect all relevant studies. For example, in both meta-analyses by Zhou et al [ 51 ] and Heydari et al [ 56 ], a cross-sectional study by Sumida et al [ 40 ] would have been included based on their eligibility criteria, but neither of them included this study. Third, some of the previous meta-analyses only calculated ORs to evaluate their association.…”

Section: Discussionmentioning

confidence: 99%

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Relationship of Helicobacter pylori Infection with Nonalcoholic Fatty Liver Disease: A Meta-Analysis

Dong

et al. 2023

Canadian Journal of Gastroenterology and Hepatology

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Background and Aims. Helicobacter pylori (H. pylori) and nonalcoholic fatty liver disease (NAFLD) have become increasingly recognized, both of which affect human health globally. The association of H. pylori infection with NAFLD remains unclear. Methods. PubMed, EMBASE, and Cochrane Library databases were searched. Only a random-effects model was used. Odds ratios (ORs) and risk ratios (RRs) with 95% confidence intervals (CIs) were calculated for the combined estimates of raw data. Adjusted ORs (aORs) and hazard ratios (aHRs) with 95% CIs were calculated for the combined estimates of data adjusted for confounders. Results. Thirty-four studies with 218573 participants were included. Based on unadjusted data from 26 cross-sectional studies and 3 case-control studies, H. pylori infection was significantly associated with the presence of NAFLD (OR = 1.26, 95% CI = 1.17–1.36, P < 0.001 ). Based on adjusted data from 15 cross-sectional studies and 1 case-control study, H. pylori infection was significantly associated with the presence of NAFLD (aOR = 1.25, 95% CI = 1.08–1.44, P < 0.001 ). Compared with control subjects without NAFLD, patients with moderate (OR = 1.67, 95% CI = 1.17–2.39, P = 0.005 ) and severe (OR = 1.71, 95% CI = 1.30–2.24, P < 0.001 ) NAFLD, but not those with mild NAFLD (OR = 1.14, 95% CI = 0.9–1.45, P = 0.286 ), had significantly higher proportions of H. pylori infection. The association of H. pylori infection with the occurrence of NAFLD was statistically significant based on adjusted data from 3 cohort studies (aHR = 1.18, 95% CI = 1.05–1.34, P = 0.007 ), but not based on unadjusted data from 3 cohort studies (RR = 1.41, 95% CI = 0.80–2.48, P = 0.237 ). Conclusion. H. pylori infection is associated with NAFLD, especially moderate and severe NAFLD. The impact of H. pylori eradication on the prevention of NAFLD should be further explored.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Relationship of Helicobacter pylori Infection with Nonalcoholic Fatty Liver Disease: A Meta-Analysis

Dong

et al. 2023

Canadian Journal of Gastroenterology and Hepatology

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“…Three meta-analyses showed an increased risk of NAFLD in H. pylori-positive patients compared to H. pylori-negative patients, with odds ratios (ORs) ranging from 1.19 to 1.27. [12][13][14] Two additional meta-analyses reported ORs of 1.36 to 1.38 for H. pylori infection in NAFLD patients. 1,15 The most recent of these meta-analyses by Heydari et al, 12 published in 2022, included 22 studies and over 117,000 patients, had a 27% increased risk of developing NAFLD in patients with H. pylori infection.…”

Section: Association Between H Pylori Infection and Nafldmentioning

confidence: 99%

“…[12][13][14] Two additional meta-analyses reported ORs of 1.36 to 1.38 for H. pylori infection in NAFLD patients. 1,15 The most recent of these meta-analyses by Heydari et al, 12 published in 2022, included 22 studies and over 117,000 patients, had a 27% increased risk of developing NAFLD in patients with H. pylori infection.…”

Section: Association Between H Pylori Infection and Nafldmentioning

confidence: 99%