Helicobacter pylori infection and type 1 diabetes mellitus in children

Abstract

Objectives This study aimed to investigate the association between Helicobacter pylori infection with diabetes mellitus type one and the effect of infected Helicobacter pylori on glycemic control. Methods This case control study was conducted on children with and without type 1 diabetes mellitus (T1DM). Demographic data and gastrointestinal symptoms in both groups and glycemic control status and duration of diabetes were recorded in patients with T1DM. Stool test was done on all children to detect Helicobacter pylori antigen. Results Sixty three children with T1DM with a mean of 10.88 ± 2.84 years and 105 control children with an average age 10.17 ± 2.55 years (P = 0/09) were involved in this study. The frequency of Helicobacter pylori infection in patients with T1DM was 17/ 63 (27%) and 25/105 (23.8%) in control group, (P = 0/64). The frequency of bloating, epigastric pain and nausea was not significantly different between the two groups. The frequency of epigastric pain in children with diabetes with helicobacter infection was significantly higher than non-infected children with diabetes (29.4% vs. 2.2%) (P = 0.004).The mean duration of diabetes (P = 0.53), age diagnosis of diabetes (P = 0.09), fasting blood glucose (P = 0.18), glycosylated hemoglobin (P = 0.08) and the daily insulin dose (P = 0.18) in patients with T1DM with and without helicobacter pylori infection had not significantly different. Conclusions There was no significant association between Helicobacter pylori infection and diabetes in children 5-15 years old, and glycemic control status was not difference in patients with T1DM with and without Helicobacter pylori infection.

The causal effect of Helicobacter pylori infection on coronary heart disease is mediated by the body mass index: a Mendelian randomization study

“…Regarding lipids, a study showed that H. pylori infection can reduce the level of HDL and increase the levels of LDL and TG 51 . However, other studies have presented opposite findings 52,53 . Meta-analyses and prospective studies of large samples have shown that eradication of H. pylori infection has no significant effect on the levels of HDL, TG, or LDL 6,54 .…”

A Significant Association between Type 1 Diabetes and Helicobacter pylori Infection: A Meta-Analysis Study

“…Similarly, this present meta-analysis found a positive association between T1DM and H. pylori infection, although it did not reach statistical significance. Another study revealed that H. pylori infection was not significantly associated with T1DM in children and that the glycemic control in these patients was similar between those who developed H. pylori infection and those who did not [34]. The potential association between H. pylori infection and T1DM remains a topic of debate, particularly in terms of glycemic control, gastrointestinal symptoms, infection prevalence, eradication and reinfection rates, and sanitary conditions [29].…”

“…This exclusion covered a range of factors, including 106 duplicate articles, 267 pieces with outcomes not directly pertinent to the investigation, as well as 66 articles categorized as reviews, letters, meta-analysis studies, and case reports. Following this rigorous culling, a meticulously curated set of 12 articles were selected and emerged as prime candidates for the study, as illustrated in Figure 1 [23][24][25][26][27][28][29][30][31][32][33][34].…”

Helicobacter Pylori and Autoimmune Diseases: Involving Multiple Systems

“…Esmaeili et al ( 67 ), however, drew the opposite conclusion that H. pylori infection has no obvious connection with diabetes mellitus in children aged 5-15 years, and there is obvious difference in blood glucose control between T1DM patients who are H. pylori positive and those who are H. pylori negative. Results of a meta-analysis conducted by Dai et al suggested that H. pylori infection was positively correlated with HbA1c levels in T1DM adolescents and children ( 68 ).…”