Helicobacter pylori infection assessed by ELISA and by immunoblot and noncardia gastric cancer risk in a prospective study: the Eurgast-EPIC project

González, Carlos; Mégraud, Françis; Buissonnière, Alice; Luján-Barroso, Leila; Agudo, Antonio; Duell, Eric J.; Boutron‐Ruault, Marie‐Christine; Clavel-Chapelon, F; Palli, Domenico; Krogh, Vittorio; Mattiello, Amalia; Tumino, Rosario; Sacerdote, Carlotta; Quiŕos, J. Ramón; Sánchez‐Cantalejo, Emilio; Navarro, Carmen; Barricarte, Aurelio; Dorronsoro, Miren; Khaw, Kay Tee; Wareham, Nick; Allen, Naomi E.; Tsilidis, Kostas; Bueno‐de‐Mesquita, H. Bas; Jeurnink, Suzanne M.; Numans, Mattijs E.; Peeters, Petra H.M.; Λάγιου, Παγώνα; Valanou, Elisavet; Trichopoulou, A.; Kaaks, Rudolf; Lukanova-McGregor, Annekatrin; Bergman, Manuela; Boeing, Heiner; Manjer, Jonas; Lindkvist, Björn; Stenling, Roger; Hallmans, Göran; Mortensen, Lotte Maxild; Overvad, Kim; Olsen, Anja; Tjønneland, Anne; Bakken, Kjersti; Dumeaux, Vanessa; Lund, Eiliv; Jenab, Mazda; Romieu, Isabelle; Michaud, Dominique S.; Mouw, Traci; Carneiro, Fátima; Fenge, C.; Riboli, Elio

doi:10.1093/annonc/mdr384

Cited by 114 publications

(92 citation statements)

References 18 publications

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“…Serology of H. pylori was available for 43 of the 48 GC cases, being positive for 41 of them, but was not available for the subcohort. However, a recent study (30) suggests that H. pylori infection is a necessary condition for gastric carcinogenesis and, therefore, adjustment or stratified analysis by H. pylori would be uninformative, at least for noncardia GC. In addition to potential confounders we also investigated the effect according to levels of the potential sources of DNA adducts.…”

Section: Discussionmentioning

confidence: 99%

Aromatic DNA Adducts and Risk of Gastrointestinal Cancers: A Case–Cohort Study within the EPIC–Spain

Agudo

Peluso

Munnia

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Colorectal (CRC) and gastric cancer (GC) are associated with meat intake and tobacco smoke, maybe because of aromatic compounds occurring in tobacco smoking and formed during cooking meat. Activated metabolites of these compounds may bind to DNA forming bulky adducts.Methods: Forty-eight subjects diagnosed of GC and 154 of CRC during a 7-year follow-up period in the European Prospective Investigation into Cancer and Nutrition-Spain cohort were compared with a sample of 296 subjects using a case-cohort approach. Aromatic adducts to DNA from leukocytes collected at recruitment were measured by means of the

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Section: Discussionmentioning

confidence: 99%

Aromatic DNA Adducts and Risk of Gastrointestinal Cancers: A Case–Cohort Study within the EPIC–Spain

Agudo

Peluso

Munnia

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…For this reason, some authors looked at CagA antibodies that are supposed to persist for longer periods of time after curing the infection by antibiotic treatment, or spontaneous clearance during the progression of atrophy. In a nested European case-control study from the Eurogast-EPIC project, Gonzalez et al [12] showed by using immunoblot detecting CagA antibodies that nearly, all noncardia-gastric cancer cases were indeed H. pylori positive, with an odds ratio three times higher than that obtained by ELISA.…”

Section: Epidemiologymentioning

confidence: 99%

Epidemiology and Diagnosis of Helicobacter pylori Infection

et al. 2012

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Medline, PubMed and the Cochrane databases were searched on epidemiology and diagnosis of Helicobacter pylori for the period of April 2011-March 2012. Several studies have shown that the prevalence of H. pylori infection is decreasing in adults and children in many countries. Various diagnostic tests are available, and most of them have high sensitivity and specificity. The Maastricht IV/Florence consensus report states that the urea breath test using 13 C urea remains the best test to diagnose H. pylori infection. Among the stool antigen tests, the ELISA monoclonal antibody test is recommended. All these tests were used, either as a single diagnostic test or in combination, to investigate H. pylori infection among different populations throughout the world. Of particular interest, current improvements in high-resolution endoscopic technologies enable increased diagnostic accuracy for the detection of H. pylori infection, but none of these techniques, at present, are specific enough for obtaining a real-time diagnosis of H. pylori infection.

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“…In point of fact, bias due to the differences in the methods used to detect HP and a systemic and substantial under-detection of Helicobacter pylori infection and underestimation of its effect on gastric cancer is at the end not excluded. (Nomura et al, 1991) 1991 USA 295 92 109 111 186 Nomura et al (Parsonnet et al, 1991) 1991 USA 218 103 109 83 109 Uemura et al (Uemura et al, 2001) 2001 Japan 1526 36 36 1210 1490 Miki (Miki 2011) 2011 Japan 5290 59 63 4151 5227 González et al (González et al, 2012) …”

Section: The Data Of the Studies Analyzedmentioning

confidence: 99%

Helicobacter Pylori is the Cause of Gastric Cancer

Barukčić¹

2018

MHS

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Objective: This study presents a systematic meta-analysis of the relationship between Helicobacter pylori (HP) infection and gastric cancer (GC). Materials and Methods:Twelve articles including 21589 subjects were selected (1237 cases and 20352 controls).These data were analyzed using the mathematical formula of the conditio sine qua non relationship and the causal relationship formula. Results:The data re-analyzed support the Null hypothesis without a Helicobacter pylori infection no human gastric cancer. The causal relationship between HP and GC is highly significant. Conclusion:Helicobacter pylori is the cause of human gastric cancer.

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Helicobacter pylori infection assessed by ELISA and by immunoblot and noncardia gastric cancer risk in a prospective study: the Eurgast-EPIC project

Abstract: Using a western blot assay, nearly all noncardia GC were classified as H. pylori positive and the OR was more than threefold higher than the OR assessed by ELISA, supporting the hypothesis that H. pylori infection is a necessary condition for noncardia GC.

Cited by 114 publications

References 18 publications

Aromatic DNA Adducts and Risk of Gastrointestinal Cancers: A Case–Cohort Study within the EPIC–Spain

Aromatic DNA Adducts and Risk of Gastrointestinal Cancers: A Case–Cohort Study within the EPIC–Spain

Epidemiology and Diagnosis of Helicobacter pylori Infection

Helicobacter Pylori is the Cause of Gastric Cancer

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