Helicobacter pylori Infection, Gastric Cancer and Gastropanel

Loor, Alexandra; Dumitraşcu, Dinu Iuliu

doi:10.1515/rjim-2016-0025

Cited by 21 publications

(25 citation statements)

References 13 publications

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“…[ 75 ] During this process, H. pylori antibody and serum PG concentration showed significant changes, which can be used for risk stratification of gastric cancer in clinic. [ 76 77 78 ]…”

Section: Discussionmentioning

confidence: 99%

Gastric Cancer Screening by Combined Determination of Serum Helicobacter pylori Antibody and Pepsinogen Concentrations

Chen

Huang

et al. 2018

Chinese Medical Journal

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Objective:Gastroscopy combined with gastric mucosa biopsies is currently regarded as a gold standard for diagnosis of gastric cancer. However, its application is restricted in clinical practice due to its invasive property. A new noninvasive population screening process combining the assay of anti-Helicobacter pylori antibody and serum pepsinogen (PG) (ABC method) is adopted to recognize the high-risk patients for further endoscopy examination, avoiding the unnecessary gastroscopy for most population and saving the cost consumption for mass screening annually. Nevertheless, controversies exist for the grouping of ABC method and the intervals of gastroscopy surveillance for each group. In this review, we summarized these popular concerned topics for providing useful references to the healthcare practitioner in clinical practice.Data Sources:The PubMed databases were systematically searched from the inception dates to November 22, 2017, using the keywords “Helicobacter pylori,” “Pepsinogens,” and “Stomach Neoplasms.”Study Selection:Original articles and reviews on the topics were selected.Results:Anti-H. pylori antibody and serum PG concentration showed significant changes under the different status of H. pylori infection and the progression of atrophic gastritis, which can be used for risk stratification of gastric cancer in clinic. In addition, anti-H. pylori antibody titer can be used for further risk stratification of gastric cancer contributing to determine better endoscopy surveillance interval.Conclusions:The early detection and diagnosis of gastric cancer benefit from the risk stratification, but the cutoff values for H. pylori antibody and serum PG concentration require further modification.

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“…[ 75 ] During this process, H. pylori antibody and serum PG concentration showed significant changes, which can be used for risk stratification of gastric cancer in clinic. [ 76 77 78 ]…”

Section: Discussionmentioning

confidence: 99%

Gastric Cancer Screening by Combined Determination of Serum Helicobacter pylori Antibody and Pepsinogen Concentrations

Chen

Huang

et al. 2018

Chinese Medical Journal

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“…PG 1 is produced in the corpus and its levels are reduced in corpus atrophy. When the corpus is inflamed without glandular loss, levels of PG 1 in blood increase [20]. PG 2 is produced in the corpus, antrum and duodenum.…”

Section: Discussionmentioning

confidence: 99%

HIV related hypochlorhydria does not appear to respond to anti-retroviral therapy in Zambian adults: a case control study

Kayamba

Shibemba²,

Zyambo

et al. 2018

Pan Afr Med J

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Introduction Human Immunodeficiency Virus (HIV) infection is associated with hypochlorhydria but the mechanism is unknown. The objective of this study was to determine effects of anti-retroviral therapy (ART) on gastric physiology as measured by validated markers. Methods We studied HIV infected individuals who were either ART-naïve or on treatment with undetectable viral loads. We measured H.pylori IgG antibodies, pepsinogen (PG) 1 and 2 levels and fasting gastrin-17 using Biohit GastroPanel®. Gastric antral biopsies and juice were obtained for histology and pH respectively. Also included were historical data from HIV negative participants (n = 72) in a previous study, for reference. Results We enrolled 84 HIV positive individuals with a median age 42 years (IQR 37-40 years). 55(66%) were female, 32(38%) were ART naïve, and 52(62%) were on ART. Hypochlorhydria (pH>4) was present in 48(57%) of the HIV positive and 18(25%) of the HIV negative individuals (OR 4: 95% CI 1.9-8.5, P<0.001) with no significant effect of ART (OR 0.9: 95% CI 0.3-2.3, P = 0.82). Hypochlorhydria was not associated with the serological detection of corpus atrophy using low PG 1:2 ratio (OR 2.1: 95% CI 0.5-10.2, P = 0.37) or GastroPanel ® algorithm, (OR 0.7: 95% CI 0.01-60.1, P = 1.0). ART reduced the frequency of low PG 1:2 ratio (P = 0.001), but not the histological detection in the antrum of atrophy or non-atrophic gastritis. Conclusion ART use is associated with reduced serological evidence of corpus atrophy but has no effect on fasting pH, supporting earlier data that suggest that the mechanism of HIV-associated hypochlorhydria is multifactorial.

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“…Gastric cancer (GC) generates a heavy disease burden in China. Helicobacter pylori ( H. pylori ) infection is known to play a role in the pathogenesis in most patients with GC . Accumulating evidence has shown that H. pylori infection causes almost 90% of non‐cardiac GC .…”

Section: Introductionmentioning

confidence: 99%

“…Helicobacter pylori (H. pylori) infection is known to play a role in the pathogenesis in most patients with GC. 1 Accumulating evidence has shown that H. pylori infection causes almost 90% of non-cardiac GC. 2 Therefore, a successful eradication of H. pylori would significantly decrease the incidence of GC.…”

Section: Introductionmentioning

confidence: 99%

Influence of serum vitamin D level on Helicobacter pylori eradication: A multi‐center, observational, prospective and cohort study

Han

Yuan

et al. 2019

J of Digest Diseases

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Objectives This study was designed to test whether serum vitamin D levels affected Helicobacter pylori (H. pylori) infection and eradication rates. Methods A multicenter observational prospective cohort study was conducted. A total of 496 H. pylori− positive (H. pylori+) and 257 H. pylori‐negative (H. pylori−) patients were enrolled from four hospitals in China. Baseline serum vitamin D levels were measured and a 13C‐urea breath test (UBT) was performed for all the participants. The H. pylori+ patients were divided into two subgroups based on their serum vitamin D levels (<10 or ≥10 ng/mL). A second 13C‐UBT was performed between 4 and 8 weeks after 14‐day bismuth‐containing quadruple eradication therapies. Factors potentially affecting H. pylori eradication were determined using a questionnaire survey. Results Serum vitamin D levels were significantly lower in the H. pylori+ group than in the H. pylori− group ([17.0 ± 6.9] ng/mL vs [19.2 ± 8.0] ng/mL, P = 0.000). H. pylori eradication rate significantly differed between patients with serum vitamin D levels of <10 ng/mL and ≥10 ng/mL (71.7% vs 87.3%, P = 0.005). A multivariate analysis showed that having serum vitamin D level ≥10 ng/mL was an independent risk factor for a successful H. pylori eradication (odds ratio 0.381, 95% confidence interval 0.183‐0.791, P = 0.010). Conclusions Serum vitamin D level may affect H. pylori infection and its eradication. Randomized controlled trials are needed to find out whether vitamin D supplements may increase the H. pylori eradication rate.

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Helicobacter pylori Infection, Gastric Cancer and Gastropanel

Cited by 21 publications

References 13 publications

Gastric Cancer Screening by Combined Determination of Serum Helicobacter pylori Antibody and Pepsinogen Concentrations

Gastric Cancer Screening by Combined Determination of Serum Helicobacter pylori Antibody and Pepsinogen Concentrations

HIV related hypochlorhydria does not appear to respond to anti-retroviral therapy in Zambian adults: a case control study

Influence of serum vitamin D level on Helicobacter pylori eradication: A multi‐center, observational, prospective and cohort study

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