Helicobacter Pylori Infection in Children of Low and High Socioeconomic Status in Northeastern Brazil

Parente, José Miguel Luz; Silva, Benedito Borges da; Palha-Dias, Mírian P. S.; Zaterka, Schlioma; Nishimura, Nancy F.; Zeitune, José Murilo Robilotta

doi:10.4269/ajtmh.2006.75.509

Cited by 37 publications

(35 citation statements)

References 28 publications

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“…The results of this imunocromatographic test are in disagreement with the immunoassay tests executed in Brazil (2,3,11,13,14,(16)(17)(18)21). Our results are also in disagreement with some results obtained even in different areas of the world, by immunocromatographic assay (4,9,18) .…”

Section: Discussioncontrasting

confidence: 56%

“…Due to these characteristics, the use of FAT by immunochromatography in developing countries is attractive. To the best of our knowledge, only nine studies (2,3,11,13,14,(16)(17)(18)21) in the past ten years evaluated FAT to diagnosis H. pylori infection in Brazil, most of them used immuno-enzymatic assay and only one used immunochromatography (18) .…”

Section: Introductionmentioning

confidence: 99%

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Is the Immunocromatographic Fecal Antigen Test Effective for Primary Diagnosis of Helicobacter Pylori Infection in Dyspeptic Patients?

Nora

Hörner

Carli

et al. 2016

Arq. Gastroenterol.

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-Background -The diagnosis of H. pylori infection can be performed by non-invasive and invasive methods.The identification through a fecal antigen test is a non-invasive, simple, and relatively inexpensive test. ) and negative predictive value 73,2% (CI95% 67.5-77.6); Positive likelihood ratio was 4.7 (CI95% 2.9-7.9) and Negative Likelihood Ratio 0.4 (CI95% 0.3-0.5). The prevalence odds ratio for a positive test was 12.3 (CI95% 5.7-26.3). The index kappa between FAT and histology/urease test was 0.53 (CI95% 0.39-0.64). Conclusion -Immunochromatographic FAT is less expensive than the other methods and readily accepted by the patients but its diagnostic performance does not recommend its use in the primary diagnosis, when the patient may have an active infection.

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Section: Discussioncontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Is the Immunocromatographic Fecal Antigen Test Effective for Primary Diagnosis of Helicobacter Pylori Infection in Dyspeptic Patients?

Nora

Hörner

Carli

et al. 2016

Arq. Gastroenterol.

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“…pylori colonizes the human stomach during childhood 26 and survives in the human stomach, the only niche known to date, for the lifetime of the carrier 5 . In most of the individuals H. pylori infection may be asymptomatic, causing chronic gastritis.…”

Section: Discussionmentioning

confidence: 99%

“…The stool antigen tests based on immunoassay (ELISA) have been tested in several laboratories of the world, including in Brazil 4,[26][27][28] , and the results have been satisfactory. In Brazil, previous validation of a monoclonal stool antigen test for diagnosis of H. pylori was reported in children 27 ; however, the stool antigen test based on lateral flow chromatography has not yet been tested in adults.…”

Section: Introductionmentioning

confidence: 99%

Validation of a rapid stool antigen test for diagnosis of Helicobacter pylori infection

Silva

Villares

Monteiro

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe aim of this study was to validate the rapid lateral flow Helicobacter pylori stool antigen test (One step H. pylori antigen test, ACON laboratories, San Diego, USA; Prime diagnostics, São Paulo), using 13 C-Urea Breath Test as the gold standard for H. pylori infection diagnosis. A total of 98 consecutive patients, asymptomatic or dyspeptic, entered the study. Sixty-nine were women, with a mean age of 45.76 ± 14.59 years (14 to 79 years). In the H. pylori-positive group, the rapid stool antigen test detected H. pylori antigen in 44 of the 50 positive patients (sensitivity 88%; 95% CI: 75.7-95.5%), and six false-negative; and in the H. pylori-negative group 42 presented negative results (specificity 87.5%; 95% CI: 74.7-95.3%), and six false-positive, showing a substantial agreement (Kappa Index = 0.75; p < 0.0001; 95% CI: 0.6-0.9). Forty four of fifty patients that had positive stool antigen were H. pylori-positive, the PPV of the stool antigen test was 88% (95% CI: 75.7-95.5%), and 42 patients with negative stool antigen test were H. pylori-negative, the NPV of the stool antigen test was 87.5% (95% CI: 74.7-95.3%). We conclude that the lateral flow stool antigen test can be used as an alternative to breath test for H. pylori infection diagnosis especially in developing countries.

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“…In populations with a higher SES, the risk of acquiring it also begins early, although more slowly, reaching significantly lower rates than those seen in populations with a low SES. Acquiring the infection during childhood may be decisive to the morbidity and mortality associated with chronic H pylori infection in the adult population (49,140,156,162) .…”

Section: Group 5 Epidemiology Of Infection and Proposals For Action mentioning

confidence: 99%

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Coelho

Maguinilk

Zaterka³

et al. 2013

Arq. Gastroenterol.

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Significant progress has been obtained since the Second Brazilian Consensus Conference on Helicobacter pylori Infection held in 2004, in São Paulo, SP, Brazil, and justify a third meeting to establish updated guidelines on the current management of H. pylori infection. The Third Brazilian Consensus Conference on H pylori Infection was organized by the Brazilian Nucleus for the Study of Helicobacter, a Department of the Brazilian Federation of Gastroenterology and took place on April 12-15, 2011, in Bento Gonçalves, RS, Brazil. Thirty-one delegates coming from the five Brazilian regions and one international guest, including gastroenterologists, pathologists, epidemiologists, and pediatricians undertook the meeting. The participants were allocated in one of the five main topics of the meeting: H pylori, functional dyspepsia and diagnosis; H pylori and gastric cancer; H pylori and other associated disorders; H pylori treatment and retreatment; and, epidemiology of H pylori infection in Brazil. The results of each subgroup were submitted to a final consensus voting to all participants. Relevant data were presented, and the quality of evidence, strength of recommendation, and level of consensus were graded. Seventy per cent and more votes were considered as acceptance for the final statement. This article presents the main recommendations and conclusions to guide Brazilian doctors involved in the management of H pylori infection.

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Helicobacter Pylori Infection in Children of Low and High Socioeconomic Status in Northeastern Brazil

Cited by 37 publications

References 28 publications

Is the Immunocromatographic Fecal Antigen Test Effective for Primary Diagnosis of Helicobacter Pylori Infection in Dyspeptic Patients?

Is the Immunocromatographic Fecal Antigen Test Effective for Primary Diagnosis of Helicobacter Pylori Infection in Dyspeptic Patients?

Validation of a rapid stool antigen test for diagnosis of Helicobacter pylori infection

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

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