Helicobacter pylori infection in patients with and without coronary heart disease

Menge, H.; Lang, Alexandra; Hopert, R.; Brosius, B.; Löllgen, H; Boenigk, U.

doi:10.1016/s0016-5085(98)80916-5

Cited by 2 publications

(2 citation statements)

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“…However, a similar angiographic study of 70 patients in Germany found no significant dif-ference in rates of H pylori infection, determined using endoscopy, in patients with and without CHD (56% vs 44%; PϾ.05). 78 Furthermore, a study in Korea of 274 patients undergoing coronary angiography for suspected CHD found no difference in H pylori seroprevalence between patients without visible lesions and those with disease in 1, 2, or 3 coronary arteries. 56 In a United States-based angiographic study, H pylori serologic studies were performed in 179 patients with suspected CHD 79 ; 121 had angiographic evidence of CHD and 58 did not.…”

Section: Possible Disease Associations With H Pylori Infection Cardiomentioning

confidence: 98%

Non–Gastrointestinal Tract Associations of Helicobacter pylori Infection

Leontiadis¹,

Sharma²,

Howden³

1999

Arch Intern Med

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Helicobacter pylori infection is linked to conditions of the upper gastrointestinal tract, including peptic ulcer and gastric adenocarcinoma. It has also been associated with a wide variety of non-gastrointestinal tract conditions. However, the evidence in support of H. pylori infection as a cause of the non-gastrointestinal tract conditions is not widely understood. We reviewed the medical literature for publications and abstracts dealing with putative non-gastrointestinal tract associations of H. pylori infection. We appraised the level of evidence and applied it to an established set of 9 criteria for determining causation. We found that many studies examining a possible causal relationship have been uncontrolled or inadequately controlled. Studies have often failed to control for socioeconomic status. Studies of treating H. pylori infection in patients with these disorders have been poorly designed and inappropriately controlled, and therefore add little to the evidence base. Attention should be focused on appropriate testing for and treatment of H. pylori infection in patients with conditions that are of proven association, notably peptic ulcer disease.

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Section: Possible Disease Associations With H Pylori Infection Cardiomentioning

confidence: 98%

Non–Gastrointestinal Tract Associations of Helicobacter pylori Infection

Leontiadis¹,

Sharma²,

Howden³

1999

Arch Intern Med

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“…On the contrary, Tsai et al demonstrated that H. pylori seropositivity is not associated with several coronary risk factors in either cases or controls [90]. Menge et al stated in a review that data regarding the association between H. pylori infection and CAD are inconclusive and need further investigation [91]. And a metaanalysis of 18 epidemiological studies involving over 10000 patients failed to demonstrate a significant association between H. pylori infection and CAD [92].…”

Section: Infectious Pathogens and Atherosclero-sismentioning

confidence: 99%

Activation of the Innate Immune System in Atherosclerotic Disease

Nijhuis¹,

Keulen

Pasterkamp³

et al. 2007

CPD

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Innate immunity is the first line of defence against invading micro-organisms. The family of Toll-like receptors (TLRs) recognizes pathogen-associated molecular patterns (PAMPs) that are carried by the invading micro-organisms. Infectious pathogens have been implicated to play an important role in atherosclerosis. Nowadays, evidence is accumulating that TLRs play an important role in the initiation and progression of atherosclerosis too. A lot is known about the exogenous ligands that are able to activate the TLRs, but it is also known that endogenous ligands have the capacity to activate TLRs when exogenous ligands are absent. Studies on knockout mice, epidemiological studies and even human polymorphism studies confirmed the important role of TLRs in development and progression of atherosclerotic disease. Studies with antagonists against TLR ligands and vaccination studies demonstrated that TLR signaling might be a potential target for intervention in the initiation and progression of atherosclerosis.

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Helicobacter pylori infection in patients with and without coronary heart disease

Cited by 2 publications

References 0 publications

Non–Gastrointestinal Tract Associations of Helicobacter pylori Infection

Non–Gastrointestinal Tract Associations of Helicobacter pylori Infection

Activation of the Innate Immune System in Atherosclerotic Disease

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