Helicobacter pylori infection in patients with nonalcoholic fatty liver disease

Polyzos, Stergios A.; Παπαθεοδώρου, Αθανάσιος; Patsiaoura, Kalliopi; Katsiki, Evangelia; Zafeiriadou, Efthimia; Zavos, Christos; Anastasiadou, Kyriaki; Terpos, Evangelos

doi:10.1016/j.metabol.2012.06.007

Cited by 143 publications

(158 citation statements)

References 16 publications

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“…There are only limited clinical data regarding the association between Hp infection and NAFLD (9,17,19,28) . The presence of 16S recombinant RNA of Hp spp.…”

Section: Discussionmentioning

confidence: 99%

“…However, it remains unclear whether Hp in these specimens is an incidental finding or it has the potential to affect the natural course of NAFLD. We previously showed in an observational study (19) , that Hp infection may represent one more hit contributing in the pathogenesis of NAFLD, considered a multiple-hit disease (21) ; Hp infection may trigger TNF-α, whereas adiponectin is secondarily increased to counterbalance the pro-inflammatory cascade. This may be achieved directly or indirectly, through Hp-related increase in IR (19) .…”

Section: Discussionmentioning

confidence: 99%

“…Limited clinical data also suggest that Hp infection might contribute to the pathogenesis of NAFLD (9,17,28) . We previously showed in an observational study that Hp infection may contribute to the pathogenesis NAFDL (19) . If an association between Hp infection and NAFLD is validated, eradicating Hp infection might have therapeutic benefits in NAFLD treatment, which is currently an unmet need (24) .…”

Section: Effect Of Helicobacter Pylori Eradication On Hepatic Steatosmentioning

confidence: 97%

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EFFECT OF HELICOBACTER PYLORI ERADICATION ON HEPATIC STEATOSIS, NAFLD FIBROSIS SCORE AND HSENSI IN PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS: a MR imaging-based pilot open-label study

Polyzos

Nikolopoulos

Stogianni

et al. 2014

Arq. Gastroenterol.

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Context Limited clinical data suggest Helicobacter pylori (Hp) infection may contribute to nonalcoholic fatty liver disease (NAFLD) pathogenesis. Objectives The effect of Hp eradication on hepatic steatosis (magnetic resonance imaging), nonalcoholic fatty liver disease fibrosis score and HSENSI (Homocysteine, serum glutamic oxaloacetic transaminase, Erythrocyte sedimentation rate, nonalcoholic steatohepatitis Index) in nonalcoholic steatohepatitis patients. Methods Thirteen adult patients with biopsy-proven nonalcoholic steatohepatitis, asymptomatic for gastrointestinal disease, underwent 13C urea breath test; Hp positive patients received eradication therapy until repeat test become negative. Hepatic fat fraction, standard biochemical tests and calculation of nonalcoholic fatty liver disease fibrosis score and HSENSI were performed at baseline and month 12. Results Hepatic fat fraction was similar for between and within group comparisons. Nonalcoholic fatty liver disease fibrosis score showed a non-significant trend towards decrease in Hp(+) [-0.34 (-1.39-0.29) at baseline and -0.24 (-0.99-0.71) at month 12; P = 0.116], whereas increase in Hp(-) group [-0.38 (-1.72-0.11) and -0.56 (-1.43-0.46), respectively; P = 0.249]. HSENSI was significantly decreased only in Hp(+) group [1.0 (1.0-2.0) at baseline and 1.0 (0-1.0) at month 12; P = 0.048]. Conclusions Hp eradication had no long-term effect on hepatic steatosis, but showed a trend towards improvement in nonalcoholic fatty liver disease fibrosis score and HSENSI. These results warrant larger studies with paired biopsies.

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“…There are only limited clinical data regarding the association between Hp infection and NAFLD (9,17,19,28) . The presence of 16S recombinant RNA of Hp spp.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Effect Of Helicobacter Pylori Eradication On Hepatic Steatosmentioning

confidence: 97%

See 1 more Smart Citation

EFFECT OF HELICOBACTER PYLORI ERADICATION ON HEPATIC STEATOSIS, NAFLD FIBROSIS SCORE AND HSENSI IN PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS: a MR imaging-based pilot open-label study

Polyzos

Nikolopoulos

Stogianni

et al. 2014

Arq. Gastroenterol.

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“…Moreover, we describe for the first time the association between high fat dietinduced NAFLD and enhanced Helicobacter genus detection. Even though is a controversial issue [45,46], it has been suggested the role of Helicobacter pilory as a contributing factor in the progression of NAFLD [47][48][49], considering its eradication as effective preventive or treatment measures [50,51]. Interestingly, Helicobacter genus was dramatically reduced by quercetin treatment in our model of NAFLD, corroborating its anti-Helicobacter activity observed in in vitro and in vivo models of infection [52,53], and supporting therapeutic potential of quercetin for prevention of the spectrum of non-alcoholic fatty liver diseases.…”

Section: Thus Quercetin Reduced the Increased Firmicutes/bacteroidetesmentioning

confidence: 99%

Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation

Porras

Nistal

Martínez‐Flórez

et al. 2017

Free Radical Biology and Medicine

412

259

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Abbreviations: ALT, alanine aminotransferase; C/EBPα, CCAAT/enhancer binding protein alpha; CHOP, CCAAT-enhancer-binding protein homologous protein; CYP2E1, cytochrome P450 2E1; DAMPs, danger-associated molecular patterns; FABP1, fatty acid binding protein 1; FAS, fatty acid synthase; FAT/CD36, fatty acid translocase CD36; FFA, free fatty acid; FOXA1, forkhead box protein A1; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GRP78, 78 kDa glucose-regulated protein; HFD, high fat diet; HOMA-IR, homeostasis model assessment of insulin resistance; IAP, intestinal phosphatase alkaline; IL-6, interleukin 6; LPO, lipid peroxidation; LPS, lipopolysaccharide; LXRα, liver X receptor alpha; NAFLD, non-alcoholic fatty liver disease; NAS, NAFLD activity score; NASH, non-alcoholic steatohepatitis; NF-B , nuclear factor kappa B; NLRP3, NOD-like receptor family pyrin domain containing 3;PAMPs, pathogen-associated molecular patterns; PRRs, pattern recognition receptors; SCFAs, short-chain fatty acids; SREBP-1c, sterol regulatory element binding protein 1c; TG, triglycerides; TLR, Toll-like receptor; TNF-αtumor necrosis factor; UPR, unfolded protein response. AbstractGut microbiota is involved in obesity, metabolic syndrome and the progression of nonalcoholic fatty liver disease (NAFLD). It has been recently suggested that the flavonoid quercetin may have the ability to modulate the intestinal microbiota composition, suggesting a prebiotic capacity which highlights a great therapeutic potential in NAFLD. The present study aims to investigate benefits of experimental treatment with quercetin on gut microbial balance and related gut-liver axis activation in a nutritional animal model of NAFLD associated to obesity. C57BL/6J mice were challenged with high fat diet (HFD) supplemented or not with quercetin for 16 weeks.

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“…Hp-I might represent one further hit contributing to NAFLD pathogenesis, representing the MetS hepatic component and Hp eradication results in a trend towards improvement in NAFLD fibrosis score 8,9 ;…”

mentioning

confidence: 99%

Letter: Helicobacter pylori -related non-alcoholic fatty liver disease with concomitant metabolic syndrome as risk factor for colorectal neoplasia

Kountouras

Polyzos

Kapetanakis

et al. 2017

Aliment Pharmacol Ther

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Helicobacter pylori infection in patients with nonalcoholic fatty liver disease

Cited by 143 publications

References 16 publications

EFFECT OF HELICOBACTER PYLORI ERADICATION ON HEPATIC STEATOSIS, NAFLD FIBROSIS SCORE AND HSENSI IN PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS: a MR imaging-based pilot open-label study

EFFECT OF HELICOBACTER PYLORI ERADICATION ON HEPATIC STEATOSIS, NAFLD FIBROSIS SCORE AND HSENSI IN PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS: a MR imaging-based pilot open-label study

Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation

Letter: Helicobacter pylori -related non-alcoholic fatty liver disease with concomitant metabolic syndrome as risk factor for colorectal neoplasia

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