Helicobacter pylori infection increases risk of incident metabolic syndrome and diabetes: A cohort study

Abstract

Emerging studies have shed light on the association between Helicobacter pylori (HP) infection and cardiometabolic risk. However, there is no evidence to support a causal link for the relationship in the general population. Our aim was to determine whether HP infection is associated with the risks of incident type II diabetes mellitus (DM) in a population-based cohort consisting of adults from the general population. A total of 69235 adults enrolled in the study obtained health examinations at the Tri-Service General Hospital in Taiwan from 2010 to 2016. HP infection detection was performed by rapid urease tests (RUTs), and endoscopic examinations were used to diagnose gastroesophageal reflux disease (GERD), gastric ulcers (GUs) and duodenal ulcers (DUs). Cross-sectional and longitudinal analyses were performed to examine the association between HP infection and cardiometabolic diseases using logistic regression and Cox regression in a large population-based study. HP infection was significantly associated with the presence of metabolic syndrome (MetS) (OR = 1.26, 95%CI: 1.00–1.57) and DM (OR = 1.59, 95%CI: 1.17–2.17) only in male subjects, and abnormal endoscopic findings were also correlated with cardiometabolic diseases. Our findings demonstrated that participants with HP infection had an elevated risk of developing incident DM (HR = 1.54, 95%CI: 1.11–2.13). In addition, endoscopic findings of a DU (HR = 1.63, 95%CI: 1.02–2.63), rather than GERD or a GU, were also predictive of incident DM. In this cohort, HP infection was a statistically significant predictor of incident DM among male population.

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

“…Among 13 autoimmune diseases evidence in support of a probable role of HPI was found in four—TP, Graves’ disease, neuromyelitis optica and psoriasis [ 361 ]. Just to mention some examples of contradictory conclusions: many reports and meta-analyses suggested a positive correlation between HPI, metabolic associated fatty liver disease (MAFLD; previous term non-alcoholic fatty liver disease, NAFLD) [ 362 , 363 , 364 , 365 , 366 , 367 , 368 , 369 , 370 , 371 , 372 ], type 2 diabetes mellitus (DM)/insulin resistance [ 373 , 374 , 375 , 376 , 377 ], diabetic complications [ 378 , 379 , 380 ] and obesity [ 381 , 382 ], whereas others did not found such associations [ 383 , 384 , 385 , 386 , 387 , 388 , 389 ] and some described an inverse correlation of HPI with obesity [ 390 , 391 , 392 ]. Similarly, there is discrepancy between various studies regarding links between HPI and cardiovascular diseases (CVD) [ 333 , 393 , 394 , 395 , 396 , 397 , 398 , 399 , 400 ].…”

Association between Helicobacter pylori Infection and Diabetes: A Cross-Sectional Study in China

“…Several studies supported our results on the lack of association between H. pylori infection and diabetes [ 17 , 20 , 26 ]. In contrast, others found H. pylori infection to be positively associated with diabetes [ 19 , 21 , 27 , 28 ]. A meta-analysis that included 41 case-control studies concluded that H. pylori infection could be a potential risk factor for type 2 diabetes, while among them, two studies conducted in China both showed a negative result [ 29 ].…”

Review:Helicobacter pyloriand extragastric diseases

“…Chen et al examined the correlation between H pylori and MeS, showing a positive association (OR 1.26; CI 95%: 1.00‐1.57) only in males. A positive association was also found with T2DM (OR 1.59; CI 95%: 1.17‐2.17), especially in patients with duodenal ulcer (HR 1.63; CI 95%: 1.02‐2.63) rather than those with gastroesophageal reflux disease (GERD) or gastric ulcer . Alshareef et al described a positive association between H pylori infection and gestational diabetes (OR 2.8: CI 95%: 1.1‐7.5; P < .036) and insulin resistance in Sudanese women, while Kato et al tested 21 634 patients for active or past‐ H pylori infection and presence of DM and reported an association between current H pylori infection and increased risk of DM, which disappeared after eradication .…”