Helicobacter pylori infection induces antibodies cross-reacting with human gastric mucosa

Negrini, Riccardo; Lisato, Laura Camilla; Zanella, Isabella; Cavazzini, Luigi; Gullini, S.; Villanacci, Vincenzo; Poiesi, Claudio; Albertini, Alberto; Ghielmi, S.

doi:10.1016/0016-5085(91)90023-e

Cited by 301 publications

(177 citation statements)

References 29 publications

Supporting

Mentioning

163

Contrasting

Unclassified

Order By: Relevance

“…Our possible explanation is that the pathophysiology of proximal MALT lymphoma differs from that of distal lymphoma; proximal lymphoma might also be associated with H. pylori infection or may be H. pylori-independent autoimmune gastritis, which is generally proximal in distribution (Dixon et al, 1996). Recent studies indicate that autoimmune gastritis may derive from H. pylori infection and suggest that antibiotic resistant Table 2 Risk factor analysis for non-response of MALT lymphoma tumours may be sustained by autoantigen-responsive T cells (Negrini et al, 1991;Greiner et al, 1994). Hence, the subset of H. pylori-eradicated MALT lymphomas in proximal stomach might be associated with autoimmune-related or autonomous tumours in patients with previous H. pylori gastritis, which do not respond to H. pylori eradiation (Steinbach et al, 1999;Ruskone-Fourmestraux et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori eradication for low-grade gastric mucosa-associated lymphoid tissue lymphoma is more successful in inducing remission in distal compared to proximal disease

et al. 2007

View full text Add to dashboard Cite

A series of studies has shown that Helicobacter pylori eradication induces remission in most patients with low-grade gastric mucosaassociated lymphoid tissue (MALT) lymphoma. However, there have been few reports about the effect of bacterial treatment on the gastric MALT lymphoma in Korea, a well-known H. pylori endemic area. A total of 111 H. pylori-infected patients were prospectively enrolled in Seoul National University Hospital and 99 among them were completely followed up according to our protocol. After H. pylori eradication, tumoural response was evaluated by endoscopy and histopathology every 2 -3 months till complete remission (CR) and every 6 months after achieving CR. Median follow-up period was 41 months (range, 11 -125 months). Helicobacter pylori was successfully eradicated in all 99 patients and CR was obtained in 84 (84.8%) of 99 patients. The median time to reach CR was 3 months and 94% of CR is in continuous complete remission. Five patients with CR relapsed after 10 -22 months without the evidence of H. pylori reinfection. Cumulative recurrence rate was 2.3, 7.7 and 9.3% at 1, 2 and 3 years, respectively. Tumours were mainly located in distal stomach (67.7%) and tumours in distal stomach were associated with more favourable response than those in proximal stomach (P ¼ 0.001). Majority of patients with low-grade gastric MALT lymphoma treated by exclusive H. pylori eradication have a favourable long-term outcome, offering a real chance of cure. Tumour location could be a predictive factor for remission following H. pylori eradication.

show abstract

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori eradication for low-grade gastric mucosa-associated lymphoid tissue lymphoma is more successful in inducing remission in distal compared to proximal disease

et al. 2007

View full text Add to dashboard Cite

show abstract

“…The following murine immunoglobulin M monoclonal antibodies (MAbs) were used: MAb 54.1F6A, specific for Lewis x (G. van Dam, Leiden, The Netherlands [25]); MAb 1E52, specific for Lewis y (R. Negrini, Brescia, Italy [1,17,18]); MAb 19-O-Le, specific for H type 2 and Lewis y (Bioprobe, Amstelveen, The Netherlands [1]); MAb 4D2, specific for H type 1 (R. Negrini [1,17,18]); and MAb NAM61-1A2, specific for i antigen (D. Blanchard, Nantes, France [5]). MAbs specific for Lewis x did not cross-react with H type 2/Lewis y or vice versa; the anti-i MAb did not react with Lewis x, H type 2, or Lewis y.…”

Section: Methodsmentioning

confidence: 99%

“…The identity of these LPS epitopes with molecules of the host may play a role in the induction of H. pylori-associated autoantibodies (1,17,18) and facilitate persistence in the gastric niche of humans (31).…”

mentioning

confidence: 99%

Phase Variation in Helicobacter Pylori Lipopolysaccharide

Appelmelk¹,

Vandenbrouck-Grauls²

2003

Antigenic Variation

View full text Add to dashboard Cite

“…Mice inoculated with hybridoma cells secreting antibodies to an H. pylori lipopolysaccharide-Lewis epitope that mimics parietal cell Lewis epitopes develop gastritis (25)(26)(27)). In our model, development of parietal cell autoantibodies was directly correlated with more extensive and pronounced reactive atypia in the gastric epithelium, and more pronounced parietal cell loss.…”

Section: Lementioning

confidence: 99%

Epithelial attachment alters the outcome of Helicobacter pylori infection

Guruge

Falk

Lorenz

et al. 1998

Proc. Natl. Acad. Sci. U.S.A.

270

167

View full text Add to dashboard Cite

Genetically defined in vivo models are needed to assess the importance of target cell attachment in bacterial pathogenesis. Gastric colonization by Helicobacter pylori in human populations is common and persistent, and has various outcomes including peptic ulcers and cancer. The impact of attachment on the course of infection was examined in transgenic mice expressing a human receptor for H. pylori in their gastric epithelium. Persistent infection by a clinical isolate occurred at comparable microbial densities in transgenic and nontransgenic littermates. However, microbial attachment in transgenic mice resulted in production of autoantibodies to Lewis x carbohydrate epitopes shared by bacteria and acid-secreting parietal cells, chronic gastritis, and parietal cell loss. This model should help identify bacterial and host genes that produce attachment-related pathology.

show abstract

Helicobacter pylori infection induces antibodies cross-reacting with human gastric mucosa

Cited by 301 publications

References 29 publications

Helicobacter pylori eradication for low-grade gastric mucosa-associated lymphoid tissue lymphoma is more successful in inducing remission in distal compared to proximal disease

Helicobacter pylori eradication for low-grade gastric mucosa-associated lymphoid tissue lymphoma is more successful in inducing remission in distal compared to proximal disease

Phase Variation in Helicobacter Pylori Lipopolysaccharide

Epithelial attachment alters the outcome of Helicobacter pylori infection

Contact Info

Product

Resources

About