Helicobacter pylori infection induces gastric cancer in Mongolian gerbils

Pattern of Transcription Factor Activation in Helicobacter pylori–Infected Mongolian Gerbils

“…Cellular infiltration in the antrum was more severe in the ulcer group than in the atrophy group (Figure 1). In contrast to a previous study using strain 6 TN2GF4, no infected gerbils developed gastric cancer.…”

“…6 This strain is cag pathogenicity island (PAI) positive, vacA s1 (production of the vacuolating cytotoxin) and has functional blood group antigen binding adhesin (BabA) and outer inflammatory protein (OipA). Long-term studies (eg, 18 months) used wild-type (WT) strain TN2GF4, whereas the cag PAI mutant (isogenic cagE mutant) was used for shortterm studies (ie, 1 and 3 months).…”

“…The Mongolian gerbil (Meriones unguiculatus) has proven to be a convenient animal model for studies of H pylori infection because the gross and histologic findings mimic the lesions induced by H pylori infection in the human gastric mucosa. [5][6][7][8][9] In the present study, we investigated the roles of transcription factors in the gastric mucosa of H pylori-infected gerbils over the course of the infection in vivo.…”

Prevalence of Helicobacter pylori infection in gastric remnant after distal gastrectomy for primary gastric cancer

“…Since Warren and Marshall [6] first isolated H. pylori from the stomachs of patients with gastritis, numerous studies have demonstrated the relationship between H. pylori infection and the development of gastric cancer [7][8][9][10]. Now, H. pylori is regarded as a definite carcinogen [11] and as a trigger for the sequence of carcinogenesis, because there is strong evidence for H. pylori infection as a cause of chronic atrophic gastritis and intestinal metaplasia, two possible precancerous lesions [9,10,[12][13][14]. Our previous observations on the background mucosa of early-stage carcinoma of the GR also indicated an intimate association between atrophic gastritis and intestinal-type gastric carcinoma [2].…”

“…Although the real cause of gastric carcinogenesis is not fully understood, several environmental factors, including infection with Helicobacter pylori, have been shown to be linked with gastric carcinogenesis [5]. Since Warren and Marshall [6] first isolated H. pylori from the stomachs of patients with gastritis, numerous studies have demonstrated the relationship between H. pylori infection and the development of gastric cancer [7][8][9][10]. Now, H. pylori is regarded as a definite carcinogen [11] and as a trigger for the sequence of carcinogenesis, because there is strong evidence for H. pylori infection as a cause of chronic atrophic gastritis and intestinal metaplasia, two possible precancerous lesions [9,10,[12][13][14].…”