Helicobacter pylori Infection is Associated with Occurrence of Proteinuria in Type 2 Diabetes Patients

Abstract

Background:Type 2 diabetes (T2DM) patients are susceptible to Helicobacter pylori (HP), and it has been reported that the occurrence of proteinuria is associated with HP infection in T2DM patients; however, this view remains controversial. This meta-analysis aimed to explore the association between HP infection and the occurrence of proteinuria in T2DM patients. In addition, we hope to provide some recommendations to readers in clinical or related fields.Methods:Our meta-analysis was conducted with the methodology of the Cochrane Collaboration. Search strategies were formulated by relevant professionals. Case–control studies that compared the occurrence of proteinuria in T2DM patients with and without HP infection were involved in our meta-analysis. Relevant English or Chinese studies were searched on online databases before 2018, including PubMed, the Cochrane library, Medline, Google Scholar, the China National Infrastructure, and Wanfang database. The search strategies were “diabetic proteinuria, diabetic microalbuminuria, diabetic albuminuria, diabetic kidney disease, diabetic renal dysfunction, diabetic renal disease, diabetic nephropathy, diabetic complications, and diabetic mellitus, combined with HP.” The quality of these involved articles was separately assessed by two investigators using the Newcastle–Ottawa Scale (NOS). Odds ratios (ORs) and associated 95% confidence intervals (CIs) were extracted and pooled using fixed-effects models.Results:Seven studies involving 1029 participants were included. The quality of these seven articles was all above five stars as assessed by NOS, and there was no significant publication bias in our meta-analysis. We found that T2DM patients with HP infection had a 2.00 times higher risk of the occurrence of proteinuria than patients without HP infection (OR: 2.00, 95% CI: 1.48–2.69).Conclusions:Our analysis showed that HP infection was associated with the occurrence of proteinuria in T2DM patients. HP radical surgery might be a therapeutic option for protecting kidney function in patients with T2DM.

Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System

“…Epidemiological surveys have indicated that the possible pathological consequences of HP infection are not restricted to the gastroduodenal tract [ 15 , 16 , 17 ]. Helicobacter gastritis is correlated with a wide range of extradigestive diseases, such as heart, vessel, skin, endocrine, respiratory, hematopoietic, immune, and central nervous system conditions [ 18 , 19 ].…”

Review:Helicobacter pyloriand extragastric diseases

“…Among 47 studies analyzed, they found a lower prevalence of H pylori in patients with CKD versus controls (OR 0.64; CI 95%: 0.52‐0.79) and this result was also confirmed by a meta‐regression analysis . Shi et al, in another meta‐analysis on the association between H pylori infection and proteinuria among patients with T2DM, reported that infected diabetic patients have twice as high a risk of proteinuria as uninfected patients (OR 2.0; CI 95%: 1.48‐2.69) …”

Association between renal function and co-infection with Clonorchis sinensis and Helicobacter pylori: a cross-sectional study

“…Another meta-analysis [41] showed that Type 2 diabetes (T 2 DM) patients with Hp infection had a 2 times higher risk of the occurrence of proteinuria than patients without Hp infection, indicating that Hp infection was associated with the occurrence of proteinuria in T 2 DM patients. Hp radical surgery might be a therapeutic option for protecting renal function in patients with T 2 DM [42]. However, a cross-sectional study [43] investigating the association between Hp infection and chronic kidney disease (CKD) did not find any significant difference in the prevalence of proteinuria and the overall CKD between the Hp infection group and non-infection group.…”