Helicobacter pylori infection is associated with worse severity of Parkinson's disease

Tan, Ai Huey; Mahadeva, Sanjiv; Marras, Connie; Thalha, Abdul Malik; Kiew, Chiun Khang; Yeat, Chia Ming; Ng, Sheang Wen; Ang, Sheau Phing; Chow, S. K.; Loke, Mun Fai; Vadivelu, Jamuna; Ibrahim, Norlinah Mohamed; Yong, Hoi Sen; Tan, Chong Tin; Fox, Susan H.; Lang, Anthony E.; Lim, Shen Yang

doi:10.1016/j.parkreldis.2014.12.009

Cited by 116 publications

(87 citation statements)

References 27 publications

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“…H. pylori is the commonest bacterial infection in the gastrointestinal tract in human. H. pylori was suggested to play a role in PD as prodromal peptic ulceration is acknowledged in PD, and the immunoblot profile of serum H. pylori antibody may indicate the severity of idiopathic parkinsonism . Neuroinflammation, autoimmunity, and apoptosis induced by H. pylori infection seem to contribute to PD .…”

Section: Discussionmentioning

confidence: 99%

“…H. pylori was suggested to play a role in PD as prodromal peptic ulceration is acknowledged in PD, 37 and the immunoblot profile of serum H. pylori antibody may indicate the severity of idiopathic parkinsonism. 20,38 Neuroinflammation, autoimmunity, and apoptosis induced by H. pylori infection seem to contribute to PD. [13][14][15] Neuroinflammation appears to contribute to PD with activation of microglia, the central neurons system resident immune cells.…”

Section: Discussionmentioning

confidence: 99%

“…PD patients were three times more likely to be seropositive for H. pylori compared with controls, and their siblings were also more inclined to be both seropositive and show parkinsonism symptom . A large cross‐sectional study demonstrated the association between H. pylori positivity and worse PD motor severity . In clinical trial, H. pylori eradication improved the clinical status of PD and ameliorated motor fluctuations …”

Section: Introductionmentioning

confidence: 99%

“…16 A large cross-sectional study demonstrated the association between H. pylori positivity and worse PD motor severity. 20 In clinical trial, H. pylori eradication improved the clinical status of PD and ameliorated motor fluctuations. [21][22][23][24] Although several studies have shown a positive association of H. pylori infection with PD, [16][17][18][19] some studies have contradictory outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Meta‐analysis: Association of Helicobacter pylori infection with Parkinson's diseases

Shen

Yang

et al. 2017

Helicobacter

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Meta‐analysis: Association of Helicobacter pylori infection with Parkinson's diseases

Shen

Yang

et al. 2017

Helicobacter

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“…Data from 4484 Parkinson cases and 22 416 population controls in Denmark showed that prescriptions for H. pylori eradication drugs and proton pump inhibitors 5 or more years prior to the diagnosis of Parkinson disease were associated with an increased disease risk . In a large cross‐sectional study in Malaysia, H. pylori was also positively associated with Parkinson's disease motor severity . Further, H. pylori eradication was associated with a marked improvement at a 3‐year follow‐up in patients with idiopathic Parkinsonism in a randomised, placebo‐controlled study .…”

mentioning

confidence: 99%

Helicobacter pyloriSeropositivity and Childhood Neurodevelopment, the Rhea Birth Cohort in Crete, Greece

Karachaliou

Chatzi

Michel

et al. 2017

Paediatric Perinatal Epid

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Upper Gastrointestinal Mucosal Damage and Subsequent Risk of Parkinson Disease

Chang,

Kulkarni,

Pasricha

2024

JAMA Netw Open

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ImportanceThe gut-first hypothesis of Parkinson disease (PD) has gained traction, yet potential inciting events triggering Parkinson pathology from gut-related factors remain unclear. While Helicobacter pylori infection is linked to mucosal damage (MD) and PD, it is unknown how upper gastrointestinal MD from any source increases PD risk.ObjectiveTo evaluate any association between upper endoscopy findings of MD and subsequent clinical PD diagnosis.Design, Setting, and ParticipantsThis was a retrospective cohort study of patients with no PD history undergoing upper endoscopy with biopsy between January 2000 and December 2005, with final follow-up assessments completed July 31, 2023. The study was conducted within the Mass General Brigham system, a multicenter network in the greater Boston, Massachusetts, area. Patients with MD were matched 1:3 to patients without MD based on age, sex, and date of initial endoscopy.ExposureMD, defined as erosions, esophagitis, ulcers, or peptic injury, observed on upper endoscopy or pathology reports.Main Outcomes and MeasuresThe relative risk of PD given a history of MD, estimated using incident rate ratio (IRR) and multivariate Cox proportional hazard ratios (HRs).ResultsOf 9350 patients, participants had a mean (SD) age of 52.3 (20.3) years; 5177 (55.4%) were male; and 269 (2.9%) were Asian, 737 (7.9%) Black, and 6888 (73.7%) White. Most participants underwent endoscopy between the ages of 50 and 64 years (2842 [30.4%]). At baseline, patients with MD were more likely to have a history of H pylori infection, proton-pump inhibitor use, chronic nonsteroidal anti-inflammatory drug use, gastroesophageal reflux disease, smoking, constipation, and dysphagia. The mean (SD) follow-up time was 14.9 (6.9) years for the whole cohort, during which patients with MD were more likely to develop PD (IRR, 4.15; 95% CI, 2.89-5.97; P &lt; .001) than those without MD, even after covariate adjustment (HR, 1.76; 95% CI 1.11-2.51; P = .01). Constipation, dysphagia, older age, and higher Charlson-Deyo Comorbidity Index were also associated with higher PD risk.Conclusions and RelevanceIn this cohort study, a history of upper gastrointestinal MD was associated with elevated risk of developing a clinical PD diagnosis. Increased vigilance among patients with MD for future PD risk may be warranted.

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Helicobacter pylori infection is associated with worse severity of Parkinson's disease

Cited by 116 publications

References 27 publications

Meta‐analysis: Association of Helicobacter pylori infection with Parkinson's diseases

Meta‐analysis: Association of Helicobacter pylori infection with Parkinson's diseases

Helicobacter pyloriSeropositivity and Childhood Neurodevelopment, the Rhea Birth Cohort in Crete, Greece

Upper Gastrointestinal Mucosal Damage and Subsequent Risk of Parkinson Disease

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