Helicobacter pylori infection may increase the risk of progression of chronic hepatitis B disease among the Chinese population: a meta-analysis

Wang, Juan; Chen, Ruochan; Zheng, Yixiang; Zhao, Shushan; Li, Ning; Zhou, Rongrong; Huang, Yan; Huang, Zebing; Fan, Xue‐Gong

doi:10.1016/j.ijid.2016.07.014

Cited by 32 publications

(31 citation statements)

References 24 publications

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“…Several studies detected a similar high association between the frequency of H. pylori infection and liver cirrhosis. [27][28][29] A Chinese study found a higher prevalence (72%) of H. pylori in Chinese HBV patients than in the control group (39%). 30 However, in the present study, strong association could not be detected between the prognosis of the liver condition and H. pylori infection, except in the level of ALP.…”

Section: Discussionmentioning

confidence: 99%

Association between Severity of Liver Disease, Frequency of Helicobacter pylori Infection, and Degree of Gastric Lesion in Egyptian Patients with Hepatitis B Virus Infection

Mohamed

Elshimy

Sadik³

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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The relationship between hepatitis B virus (HBV) infection, severity of liver disease, frequency of infection, and degree of gastric lesions was not yet fully investigated in Egyptian patients. The present work was performed on 100 Egyptian patients with HBV from the National Hepatology and Tropical Medicine Institute and 70 healthy volunteers as control group. The participants were subjected to full medical history taking, clinical examination, and laboratory investigations. All patients were positive for HBV surface antigen (HBV sAg), HBV DNA, and negative for hepatitis C virus antibodies. The severity of the liver disease was assessed using Child-Pugh scoring system. Screening of all participants for Ag in stool was performed. Biopsy specimens were taken from the gastric lesions of -infected patients for histopathological examination. The mean age of the patients and control group were 34.9 and 33.4 years, respectively. The levels of the liver enzymes were statistically higher in HBV patients than the control group. Ag in stool was detected in 45.7% of the control group, and a higher percentage (60%) was detected in the patients group. Chronic gastritis with glandular atrophy and metaplasia was found in 15.6% of patients of Child-Pugh A, 70% of Child-Pugh B, and 100% of Child-Pugh C. It could be concluded that the prognosis of the liver disease significantly influences the severity of the gastric pathology in infection.

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Section: Discussionmentioning

confidence: 99%

Association between Severity of Liver Disease, Frequency of Helicobacter pylori Infection, and Degree of Gastric Lesion in Egyptian Patients with Hepatitis B Virus Infection

Mohamed

Elshimy

Sadik³

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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“…The frequency of H. pylori infection among patients with chronic hepatitis B is around 30-80% [17]. H. pylori infection is confirmed in 79% of patients with postinflammatory liver cirrhosis connected with HBV infection [18].…”

Section: Chronic Hbv and Hcv Infectionsmentioning

confidence: 99%

“…Frequency of H. pylori infection among patients with chronic hepatitis B correlates with the incidence of hepatocellular cancer, both in men and women [20]. Among this type of patients, fast progression of inflammatory changes in the liver is observed, as well as intensified fibrosis, which promotes occurrence of primary neoplastic lesions [17,21].…”

Section: Chronic Hbv and Hcv Infectionsmentioning

confidence: 99%

“…H. pylori infection may be present in even 70% of patients chronically infected with HCV [23]. Meta-analysis of 20 studies demonstrated higher incidence of H. pylori infection among HCV-positive patients, compared to persons without viral infection [17,24]. Much higher fibrosis, loss of cellular proteins, and glycogen was found in morphological studies of the liver from HCV-positive patients, if those were coinfected with H. pylori, compared to those without coinfection [25].…”

Section: Chronic Hbv and Hcv Infectionsmentioning

confidence: 99%

“…Incidence of H. pylori infection among patients with liver cirrhosis and concomitant HCV infection increases proportionally to progressing liver failure [39]. Moreover, it has been demonstrated that the highest percentage of people infected with H. pylori among those with HCV infection is observed in the case of patients in whom HCC developed [17,24]. Many pieces of information argue that concomitant infection with H. pylori and HCV increases the incidence of HCC.…”

Section: Liver Cirrhosis Hepatocellular Carcinoma (Hcc) and Cholangmentioning

confidence: 99%

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The Importance of H. pylori Infection in Liver Diseases

Łapiński¹

2018

Helicobacter Pylori [Working Title]

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The chapter is a review of current knowledge on the impact of H. pylori infection on the clinical course of patients with various forms of liver damage. H. pylori infection is found in 50-90% of the world population. The bacteria not only mainly contribute to occurrence of gastric mucosa inflammation but also to gastric ulcer and cancer. H. pylori contains an active antioxidative system, which not only neutralizes free radicals but also synthesizes specific VacA toxin, which leads to destruction and apoptosis of the cells. A specific system of bacterial CagA genes has a special role in carcinogenesis. There is an increasing number of reports describing lesions in the circulatory system, pancreas, or the skin, connected with H. pylori infection. Liver colonization by H. pylori happens after transmission of the bacteria from the stomach, with blood, through the portal vein or directly through the bile ducts. The bacteria promote liver function deterioration in the course of toxic injury, autoimmune inflammation, chronic HBV, and HCV infection. Infections among people with liver cirrhosis are especially dangerous. In this group of patients, H. pylori infection may significantly worsen liver function, leading to hyperammonemia, increased portal pressure, and development of esophageal varices. Thus, testing for and treating this infection among patients with liver cirrhosis is especially important.

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Concomitant Diseases and Co-contribution on Progression of Liver Stiffness in Patients with Hepatitis B Virus Infection

Liu

Jiang

et al. 2022

Dig Dis Sci

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Helicobacter pylori infection may increase the risk of progression of chronic hepatitis B disease among the Chinese population: a meta-analysis

Abstract: These results indicate a strong relationship between H. pylori and chronic hepatitis B, particularly during HBV progression.

Cited by 32 publications

References 24 publications

Association between Severity of Liver Disease, Frequency of Helicobacter pylori Infection, and Degree of Gastric Lesion in Egyptian Patients with Hepatitis B Virus Infection

Association between Severity of Liver Disease, Frequency of Helicobacter pylori Infection, and Degree of Gastric Lesion in Egyptian Patients with Hepatitis B Virus Infection

The Importance of H. pylori Infection in Liver Diseases

Concomitant Diseases and Co-contribution on Progression of Liver Stiffness in Patients with Hepatitis B Virus Infection

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