Helicobacter pylori Infection Status Correlates with Serum Parameter Levels Responding to Multi-organ Functions

Gong, Yuehua; Wang, Wei; Liu, Jingwei; Dong, Ning; Yuan, Yuan

doi:10.1007/s10620-015-3522-2

Cited by 18 publications

(17 citation statements)

References 43 publications

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“…These findings indicate that H. pylori colonization of the gerbil stomach leads to not only a gastric mucosal inflammatory response but also a systemic response. Previous studies reported that humans infected with H. pylori have significantly higher leukocyte counts than their uninfected counterparts (62,63). The leukocytosis observed in H. pylori-infected gerbils in the current study was substantially greater than the leukocytosis previously observed in H. pylori-infected humans.…”

Section: Discussioncontrasting

confidence: 70%

Dietary Composition Influences Incidence of Helicobacter pylori-Induced Iron Deficiency Anemia and Gastric Ulceration

et al. 2016

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Epidemiologic studies have provided conflicting data regarding an association between Helicobacter pylori infection and iron deficiency anemia (IDA) in humans. Here, a Mongolian gerbil model was used to investigate a potential role of H. pylori infection, as well as a possible role of diet, in H. pylori-associated IDA. Mongolian gerbils (either H. pylori infected or uninfected) received a normal diet or one of three diets associated with increased H. pylori virulence: high-salt, low-iron, or a combination of a high-salt and low-iron diet. In an analysis of all infected animals compared to uninfected animals (independent of diet), H. pylori-infected gerbils had significantly lower hemoglobin values than their uninfected counterparts at 16 weeks postinfection (P < 0.0001). The mean corpuscular volume (MCV) and serum ferritin values were significantly lower in H. pylori-infected gerbils than in uninfected gerbils, consistent with IDA. Leukocytosis and thrombocytosis were also detected in infected gerbils, indicating the presence of a systemic inflammatory response. In comparison to uninfected gerbils, H. pylori-infected gerbils had a higher gastric pH, a higher incidence of gastric ulcers, and a higher incidence of fecal occult blood loss. Anemia was associated with the presence of gastric ulceration but not gastric cancer. Infected gerbils consuming diets with a high salt content developed gastric ulcers significantly more frequently than gerbils consuming a normal-salt diet, and the lowest hemoglobin levels were in infected gerbils consuming a high-salt/low-iron diet. These data indicate that H. pylori infection can cause IDA and that the composition of the diet influences the incidence and severity of H. pylori-induced IDA.A nemia affects up to 1.6 billion people worldwide, potentially resulting in fatigue, decreased productivity, increased susceptibility to infection, or death (1-5). A wide variety of infectious processes can be primary causes of anemia or can exacerbate anemia arising from noninfectious etiologies. For example, intestinal parasitic infections can cause chronic blood loss, leading to iron deficiency anemia (IDA; i.e., anemia due to iron deficiency) (3, 6). Anemia arises in patients with malaria because the parasites invade erythrocytes (2), and bacterial toxins can cause hemolysis (7). In addition, chronic infections, chronic immune activation, and cancer can cause a form of anemia known as "anemia of chronic disease" (8).Colonization of the human stomach with the gastric bacterium Helicobacter pylori is another potential cause of anemia. Anemia often occurs in the setting of symptomatic H. pylori-associated diseases (peptic ulcer disease or gastric cancer), but it has been suggested that H. pylori may also be a cause of IDA in asymptomatic persons with no evidence of peptic ulcer disease or gastric cancer (9). H. pylori has been linked to several other hematologic diseases, including pernicious anemia (vitamin B 12 deficiency arising through an autoimmune-mediated process) and idiopathic throm...

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Section: Discussioncontrasting

confidence: 70%

Dietary Composition Influences Incidence of Helicobacter pylori-Induced Iron Deficiency Anemia and Gastric Ulceration

et al. 2016

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“…It has been shown that H. pylori infection was independently associated with elevated LDL-C levels and contributed to the atherosclerotic process[ 25 ]. The current study showed the difference on levels of serum LDL-C between H. pylori -infected and non-infected male subjects, which suggested an effect of H. pylori infection on raising levels of LDL-C in males.…”

Section: Discussionmentioning

confidence: 99%

Changes with aging in gastric biomarkers levels and in biochemical factors associated withHelicobacter pyloriinfection in asymptomatic Chinese population

Shan

Bai

Han

et al. 2017

WJG

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AIMTo observe changes in gastric biomarker levels with age and effects of Helicobacter pylori (H. pylori) infection in a healthy population, and explore factors associated with gastric biomarkers.METHODSThree hundred and ninety-five subjects were selected and underwent physical examinations, biochemical tests, and measurement of serum pepsinogen (PG) I and II, gastrin-17 (G-17) and H. pylori antibody levels. Analyses were made by Student’s t-test, ANOVA, Pearson’s correlation and multiple linear regressions.RESULTSPGII levels were higher in the ≥ 65-years-old age group (P < 0.05) and PGI/PGII were lower in the ≥ 75-years-old age group (P = 0.035) compared to the 35-44-years-old age group. Levels of low-density lipoprotein cholesterol (LDL-C) were higher (P = 0.009) in H. pylori-infected subjects that were male. LDL-C levels were higher in 55-74-years-old age group (P < 0.05) for H. pylori-infected subjects and 45-64-years-old age group (P < 0.05) for non-infected subjects compared to 35-44-years-old age group. Hp-IgG level positively correlated with PGI, PGII and G-17 (P < 0.001, P < 0.001, P = 0.006), and negatively correlated with PGI/PGII (P < 0.001). Creatinine positively correlated with PGI, PGII and G-17 (P < 0.001, P < 0.001, P < 0.001). Fasting blood glucose (FBG) positively correlated with PGI/PGII and G-17 (P < 0.001, P = 0.037). Age positively correlated with PGII and G-17 (P = 0.005, P = 0.026).CONCLUSIONPGII levels increased while PGI/PGII declined with age in a healthy population. H. pylori infection had an effect on raising LDL-C levels to increase the risk of atherosclerosis in males, especially those of elderly age. Age, H. pylori infection, levels of renal function and FBG were associated with levels of pepsinogens and gastrin.

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“… 41 On the other hand, H. pylori IgG is not synchronised with the H. pylori infection process, so the delayed generation or disappearance of H. pylori colonisation for several months may affect the level of anti- H. pylori IgG in the urine. 42 Indeed, Graham et al 23 reported that urine tests may remain positive for an extended time after successful treatment of the infection. This may be an important factor affecting the accuracy of the antibody test in the diseased population.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of testing for anti-Helicobacter pyloriIgG in urine forH. pyloriinfection diagnosis: a systematic review and meta-analysis

Gong

Yuan

2017

BMJ Open

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ObjectivesThis meta-analysis aims to systematically measure the potential diagnostic value of anti-Helicobacter pylori IgG in urine for infection diagnosis, using all eligible studies published in English and Chinese languages.DesignThe random effect model was used to analyse the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative LR (NLR), diagnostic OR (DOR), together with the summary receiver operator characteristic curve.SettingLiterature searches of databases including PubMed, EMBASE, MEDLINE, Web of Science, Chinese National Knowledge Infrastructure and Wanfang databases were performed to retrieve studies evaluating the diagnostic value of urine IgG antibody for H.pylori infection.Primary outcome measureTwenty-three studies with 4963 subjects were included in the current meta-analysis.ResultsThe pooled sensitivity, specificity, PLR, NLR, DOR and area under the curve (AUC) were 0.83 (95% CI 0.82 to 0.85), 0.89 (95% CI 0.88 to 0.90), 8.81 (95% CI 6.37 to 12.2), 0.13 (95% CI 0.09 to 0.2), 73 (95% CI 46.45 to 114.74) and 0.9551, respectively. Subgroup analyses showed that diagnostic accuracy of the urine IgG assay was no different in age, region, study population and assay method.ConclusionsAnti-H. pylori antibody in urine might serve as a good marker in diagnosing H. pylori infection. However, further validation based on a larger sample is still required.

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Helicobacter pylori Infection Status Correlates with Serum Parameter Levels Responding to Multi-organ Functions

Cited by 18 publications

References 43 publications

Dietary Composition Influences Incidence of Helicobacter pylori-Induced Iron Deficiency Anemia and Gastric Ulceration

Dietary Composition Influences Incidence of Helicobacter pylori-Induced Iron Deficiency Anemia and Gastric Ulceration

Changes with aging in gastric biomarkers levels and in biochemical factors associated withHelicobacter pyloriinfection in asymptomatic Chinese population

Accuracy of testing for anti-Helicobacter pyloriIgG in urine forH. pyloriinfection diagnosis: a systematic review and meta-analysis

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