Helicobacter pylori isolates from Greek children express type 2 and type 1 Lewis and α1,6-glucan antigens in conjunction with a functional type IV secretion system

Altman, Eleonora; Chandan, Vandana; Harrison, Blair A.; Panayotopoulou, Effrosini; Roma-Giannikou, Eleftheria; Li, Jianjun; Sgouras, Dionyssios N.

doi:10.1099/jmm.0.038729-0

Cited by 8 publications

(9 citation statements)

References 25 publications

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“…Lewis (Le) blood‐group epitopes on the surface of H. pylori mimic structures present on human gastric surfaces and could be implicated in adverse autoimmune reactions of the host. Most studies in adults found that the majority of the H. pylori strains express type 2 Le x and/or Le y antigens, while pediatric isolates have the tendency to express also type 1 Le b antigen . Moreover, pediatric isolates have overwhelming presence of α1,6‐glucan, yet another phenotypic characteristic that facilitates colonization and contributes to the antigenic diversity of H. pylori surface .…”

Section: Pathophysiologymentioning

confidence: 99%

“…Most studies in adults found that the majority of the H. pylori strains express type 2 Le x and/or Le y antigens, while pediatric isolates have the tendency to express also type 1 Le b antigen . Moreover, pediatric isolates have overwhelming presence of α1,6‐glucan, yet another phenotypic characteristic that facilitates colonization and contributes to the antigenic diversity of H. pylori surface . For better understanding of the host immune response to H. pylori infection, Freire De Melo et al .…”

Section: Pathophysiologymentioning

confidence: 99%

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Helicobacter pylori in Pediatrics

2012

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This review summarizes important pediatric studies published from April 2011 up to March 2012. Proteomics profile of ulcerogenic Helicobacter pylori strains was defined in the most interesting study of the last year. The antigen stool test is becoming the "gold standard" in prevalence studies, and according to the last epidemiologic studies, the prevalence of H. pylori infection in childhood is not decreasing any more in the developed world. The resistance rate of H. pylori strains is high in children. Therefore, among other important issues concerning H. pylori in pediatrics, guidelines published by ESPGHAN and NASPGHAN last year also recommended culture and susceptibility testing before first-line treatment in areas with high or unknown antibiotic resistance rates.

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Section: Pathophysiologymentioning

confidence: 99%

Section: Pathophysiologymentioning

confidence: 99%

Helicobacter pylori in Pediatrics

2012

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“…It has been reported that the LPS glucan is expressed by the majority of H. pylori isolates from Greek children [ 38 ]. Another study by the same group reported the glucan expression was 73% (30/41) in Canadian H. pylori isolates [ 39 ].…”

Section: Lps Structure In Western H Pylori Strmentioning

confidence: 99%

Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains

Tang

Debowski

et al. 2018

Toxins

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Recent structural analysis of the lipopolysaccharide (LPS) isolated from Helicobacter pylori G27 wild-type and O-antigen ligase mutant resulted in the redefinition of the core-oligosaccharide and O-antigen domains. The short core-oligosaccharide (Glc–Gal–Hep-III–Hep-II–Hep-I–KDO) and its attached trisaccharide (Trio, GlcNAc–Fuc–Hep) appear to be highly conserved structures among H. pylori strains. The G27 LPS contains a linear glucan–heptan linker between the core-Trio and distal Lewis antigens. This linker domain was commonly identified in Western strains. In contrast, out of 12 partial LPS structures of Asian strains, none displayed the heptan moiety, despite the presence of Lewis antigens. This raises the question of how Lewis antigens are attached to the Trio, and whether the LPS structure of Asian strains contain another linker. Of note, a riban was identified as a linker in LPS of the mouse-adapted SS1 strain, suggesting that alternative linker structures can occur. In summary, additional full structural analyses of LPS in Asian strains are required to assess the presence or absence of an alternative linker in these strains. It will also be interesting to study the glucan-heptan linker moieties in pathogenesis as H. pylori infections in Asia are usually more symptomatic than the ones presented in the Western world.

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“…Rotavirus is classified in the genus Rotavirus of the family Reoviridae , and comprises icosahedral, non-enveloped viruses with 11 segments of double-stranded RNA as the genome [1]. Genus Rotavirus is further classified into species, and species Rotavirus A (RVA), Rotavirus B (RVB) and Rotavirus C (RVC) have been detected in humans [1].…”

Section: Introductionmentioning

confidence: 99%

“…Genus Rotavirus is further classified into species, and species Rotavirus A (RVA), Rotavirus B (RVB) and Rotavirus C (RVC) have been detected in humans [1]. RVB is also detected in various animals including lambs, pigs, cattle, goats and rats [2–7].…”

Section: Introductionmentioning

confidence: 99%

The First Identification of Rotavirus B from Children and Adults with Acute Diarrhoea in Kathmandu, Nepal

et al. 2013

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Rotavirus B (RVB) in the genus Rotavirus of the family Reoviridae is known to be a cause of acute gastroenteritis among children and adults in parts of Asia including China, India, Bangladesh and Myanmar. In a 15-month surveillance programme between March 2007 and May 2008, 3,080 stool specimens were collected from children and adults with acute gastroenteritis in an infectious disease hospital in Kathmandu, Nepal. In 25 (0.8%) specimens RVB was detected, for the first time in Nepal, by the use of polyacrylamide gel electrophoresis followed by confirmation with reverse-transcription PCR and sequencing. The strains detected in this study had very similar electropherotypes, and their VP7 sequences were almost identical and phylogenetically belonged to the Indo-Bangladeshi lineage which was distinct from the Chinese lineage. Thus, this study showed the circulation of RVB strains belonging to the Indo-Bangladeshi lineage in a broader region than previously documented, suggesting that this phylogenetic divide corresponded to the geographic divide created by the Himalayan Mountains. Further studies may be warranted to identify and characterize the RVB strains in northern Vietnam which is adjacent to southern China with a long and less mountainous border.

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Helicobacter pylori isolates from Greek children express type 2 and type 1 Lewis and α1,6-glucan antigens in conjunction with a functional type IV secretion system

Cited by 8 publications

References 25 publications

Helicobacter pylori in Pediatrics

Helicobacter pylori in Pediatrics

Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains

The First Identification of Rotavirus B from Children and Adults with Acute Diarrhoea in Kathmandu, Nepal

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