HELICOBACTER PYLORI PREVALENCE IN PATIENTS WITH CELIAC DISEASE: results from a cross-sectional study

Lasa, Juan S.; Zubiaurre, Ignacio; Dima, Guillermo; Peralta, Daniel; Soifer, Luis

doi:10.1590/s0004-28032015000200012

Cited by 22 publications

(19 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been established that Hp infection causes duodenitis and induces intra‐epithelial lymphocytosis, whereby Hp infection may contribute to more severe damage in patients with CD. In this study, the histologic severity of duodenal lesions was not influenced by the presence of Hp infection, and it was comparable to the previous publications 12,21,30 . However, there are studies demonstrating milder inflammation in the duodenum of celiac patients when there was a concomitant Hp infection.…”

Section: Discussionsupporting

confidence: 90%

“…The relationship between CD and Hp infection has been studied previously; however, the results were either contradictory or inconclusive 11,13,20‐23 . Studies done in adults reported that the rate of Hp infection varied between 12.5%‐20.7% in celiac patients, compared with 30%‐55.3% in the dyspeptic adults who had been examined by endoscopy and histopathology 10,12 . Our findings in this study were comparable to those, and the rates of Hp infection were 26.3% vs. 50.1% in CD and controls, respectively.…”

Section: Discussionsupporting

confidence: 58%

“…Hygiene hypothesis might be an explanation for the underlying pathogenesis 6 . Furthermore, the interaction between microorganism and the host might alter the immunogenicity of ingested gluten via the modification of gastric pH 12 or the cross talk between them 35 . Moreover, it has been shown that Hp might modulate the gastroduodenal permeability 8 .…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, the prevalence of Hp has decreased during the last decades all over the world, but at a faster rate in developed countries 9 . It has been suggested that the decline in Hp frequency might be associated with the increased frequency of autoimmune disorders such as CD in children 10‐13 . Furthermore, the latest pediatric guideline for the management of Hp in children underlines that Hp infection in early childhood might have immunologic benefits later in life 14 .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Helicobacter pylori infection in children with celiac disease: Multi‐center, cross‐sectional study

et al. 2020

View full text Add to dashboard Cite

Background An inverse association has been suggested between celiac disease (CD) and Helicobacter pylori (Hp) infection in children; however, there are inconsistent data. The purpose of this multi‐center study is to evaluate the association between Hp and CD in childhood. Methods Children who underwent endoscopy between July 2016 and November 2017 in four pediatric gastroenterology centers were included in the study. Patients with a history of previous Hp eradication, antibiotic or acid‐suppressive drug therapy in the last 4 weeks, and any underlying chronic disease were excluded. The presence of Hp infection was confirmed by both histopathology and the rapid urease test. The ones who had the diagnosis of CD were compared with the children who underwent endoscopy during the same period and had another diagnosis. Duodenal histopathology of children with CD was categorized according to the modified Marsh classification. Results Of 3056 endoscopies performed in the study period, 2484 cases were eligible for the study. A total of 482 CD patients (mean age: 9.71 ± 4.63 years, 58.5% girls) and 2060 controls (mean age: 9.92 ± 4.66 years, 54.6% girls) were included in the study. The rate of Hp infection was significantly lower in CD group (26.3% vs 50.1%, P < .01). The difference was prominent even in children younger than 6 years old (P < .01). There was no correlation between Hp infection and the modified Marsh scores in CD (P > .05). Conclusion In this cross‐sectional study, where Hp infection is common even in the pediatric population, the frequency of Hp infection was significantly lower in children with CD compared with the controls. Systematic cohort studies are necessary to clarify causal association between Hp infection and the development of celiac disease.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Helicobacter pylori infection in children with celiac disease: Multi‐center, cross‐sectional study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Celijakija se nekada može javiti udruženo sa drugim oboljenjima kao što su: dermatitis herpetiformis -Duhring, insulin zavisni dijabetes melitus (IDDM), hipotireoidizmom, Daunov i Tarnerov sindrom ili mikroskopski kolitis (6,8,10). U želucu, kod pacijenata sa celijakijom, može se udruženo naći limfocitni gastritis (LG) dok rezultati istraživanja sugerišu manju učestalost hroničnog Helicobacter pylori (Hp) pozitivnog gastritisa (11,12).…”

Section: Uvodunclassified

Histopathological changes of gastric mucosa in celiac disease

Otašević¹,

Jovanović²

2018

Medicinski podmladak

View full text Add to dashboard Cite

Introduction: Celiac disease (CD) is a chronic autoimmune disease caused by ingestion of gluten in genetically susceptible individuals. Lymphocytic gastritis (LG) can be found in CD patients, with possible lower incidence of chronic Helicobacter pylori (Hp) positive gastritis. Aim: The aim was to assess the frequency and type of histopathological changes of gastric mucosa in patients with proven CD. Material and methods: This study included patients who underwent esophagogastroduodenoscopy (EGDS) and histopathological examination. Patients were distributed into two groups: patients with and without histopathological alterations indicative of CD. Results: The study included 351 patients. CD was detected in 145 (41.3%) patients, while the control group consisted of 206 (58.7%) patients without CD confirmation. The most common symptom in CD patients was diarrhea, while patients in the control group most often complained of dyspepsia, fatigue and bloating (p = 0.001). Chronic superficial gastritis was the most common gastritis in both groups of patients (76% and 63.6%; p > 0.05). Gastritis associated with Hp infection was present in 29.3% of CD patients, which is significantly less than in people without CD where 62% of gastritis is associated with Hp infection (p < 0.001). In this study we haven't discovered other forms of gastritis. Patients with CD had significantly lower incidence of Hp infection compared to the control group (15.7% vs. 37.9%; p < 0.001). Marsh IIIa degree was significantly more prevalent in Hp-patients compared to Hp+ patients (39.8% vs. 9.1%; p=0.005). Marsh IIIc was more prevalent in Hp+ patients (63.6% prema 35%; p = 0.011). The presence of Hp infection affects the degree of damage to duodenal mucosa (p = 0.011). Conclusion: The prevalence of Hp infection was significantly lower in CD patients. The higher degree of damage to duodenal mucosa in Hp+ CD patients may contribute to the possible synergistic effect of infection and autoimmunity in CD.

show abstract

Gut Microbiota and Celiac Disease

et al. 2016

View full text Add to dashboard Cite

Recent evidence regarding celiac disease has increasingly shown the role of innate immunity in triggering the immune response by stimulating the adaptive immune response and by mucosal damage. The interaction between the gut microbiota and the mucosal wall is mediated by the same receptors which can activate innate immunity. Thus, changes in gut microbiota may lead to activation of this inflammatory pathway. This paper is a review of the current knowledge regarding the relationship between celiac disease and gut microbiota. In fact, patients with celiac disease have a reduction in beneficial species and an increase in those potentially pathogenic as compared to healthy subjects. This dysbiosis is reduced, but might still remain, after a gluten-free diet. Thus, gut microbiota could play a significant role in the pathogenesis of celiac disease, as described by studies which link dysbiosis with the inflammatory milieu in celiac patients. The use of probiotics seems to reduce the inflammatory response and restore a normal proportion of beneficial bacteria in the gastrointestinal tract. Additional evidence is needed in order to better understand the role of gut microbiota in the pathogenesis of celiac disease, and the clinical impact and therapeutic use of probiotics in this setting.

show abstract

HELICOBACTER PYLORI PREVALENCE IN PATIENTS WITH CELIAC DISEASE: results from a cross-sectional study

Cited by 22 publications

References 20 publications

Helicobacter pylori infection in children with celiac disease: Multi‐center, cross‐sectional study

Helicobacter pylori infection in children with celiac disease: Multi‐center, cross‐sectional study

Histopathological changes of gastric mucosa in celiac disease

Gut Microbiota and Celiac Disease

Contact Info

Product

Resources

About