Helicobacter pylori : quand rechercher une infection et la traiter chez l’adulte ?

Korwin, J. D. De

doi:10.1016/j.revmed.2020.11.012

Cited by 4 publications

(6 citation statements)

References 30 publications

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“…Our study identified gastric ulcers, smoking and heart disease as antecedent or antecedent factors leading to gastric cancer, with a significant impact on survival and poor prognosis. Our results are supported by those found by J.-D. Korwin et al [27] whoshowed in their study that patients with gastric ulcers most often develop gastric cancer. The common denominator of these two pathologies is the infection with the bacterium Helicobacter pylori.…”

Section: Discussionsupporting

confidence: 93%

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Study of prognostic factors in gastric cancer: Application of a cox model and logistic regression

SY¹,

Bousso²,

Correa³

et al. 2022

Int. J. Stat. Appl. Math.

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Introduction: Gastric cancer has a poor prognosis. It is the fifth most common cancer in terms of incidence and the fourth most common cancer in terms of mortality world wide. The aim of our study is to identify the clinical and pathological factors associated with survival and predictive of death. Method: Our study included 262 patients over a 13-year periodfrom 2007 to 2020 at Aristide Le Dantec Hospital in Senegal and Conakry Hospital in Guinea. The survival period was established from one month after treatment to the date of death or last news. We first used the Cox proportional hazard model to identify independent factors associated with survival. Then we applied logistic regression to these factors to develop the prognostic equation. Results:The overall survival at 6 months, 1 year and 5 years after treatment was respectively 74%, 57%, 38%. The probability of occurrence of death after 5 years can be estimated with 93\% accuracy, by: log (π i / (1 -π i )) = -19,983 + 2,119* Métastases + 1,268* Ulcère gastrique + 1,100* Tabac + 37,646* Epigastralgie + 37,563* Cardiopathie + 37,220*Mucineux. Conclusion: Our approach contributes to determine the impact of clinical and pathological factors on the survival of patients and the eventual occurrence of death related to stomach cancer.

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Section: Discussionsupporting

confidence: 93%

“…The common denominator of these two pathologies is the infection with the bacterium Helicobacter pylori. Chronic gastritis caused by the bacterium can lead to ulcers and in the long term, transform the mucosa and induce mutation of it scells into cancer cells [27] .…”

Section: Discussionmentioning

confidence: 99%

Study of prognostic factors in gastric cancer: Application of a cox model and logistic regression

SY¹,

Bousso²,

Correa³

et al. 2022

Int. J. Stat. Appl. Math.

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“…In the current study, approximately 29% of the cases were pancreatic fibrosis (including early chronic pancreatitis) simultaneously infected by Helicobacter pylori. The infection of Helicobacter pylori is the treatment priority in the management of dyspepsia [ 1 , 48 ]. Then, it is reasonable to survey pancreatic fibrosis in non-ulcer dyspeptic patients after the eradication of Helicobacter pylori.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Fibrosis (Early Chronic Pancreatitis) as Emerging Diagnosis in Structural Causes of Dyspepsia: Evidence from Endoscopic Ultrasonography and Shear Wave Elastography

et al. 2021

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A new concept for the diagnosis and management of non-functional dyspepsia in guidelines was lacking in the past decade. Medical advancement has proven pancreatic fibrosis (essential image evidence of early chronic pancreatitis) to be a cause of dyspepsia and related to pancreatic exocrine dysfunction. This study aimed to analyze the clinical picture, biomarker, and percentage of pancreatic fibrosis in the dyspeptic population. A total of 141 consecutive patients were retrospectively enrolled. They were diagnosed with peptic ulcer disease, 9.2% (n = 13); pancreatic fibrosis, 17% (n = 24); pure Helicobacter pylori infection, 19.9% (n = 28); functional dyspepsia, 53.2% (n = 75); and chronic pancreatitis, 0.7% (n = 1). Among those with pancreatic fibrosis, (n = 24), 11 were diagnosed on the basis of a pancreatic acoustic radiation force impulse exceeding 1.4 m/s, and the remaining 13 were diagnosed with early chronic pancreatitis with at least three of the Japanese endoscopic ultrasonography criteria. The anatomic distribution of parenchymal criteria of early chronic pancreatitis was head, 53%; body, 38%; and tail, 9%. There were 17 cases (71%, 17/24) without Helicobacter pylori and whose dyspepsia improved after pancreatic enzyme replacement with a ratio of 82.3% (14/17). Of the 141 cases, 19 received gastric emptying scintigraphy and Western blot analysis of chromogranin-A in duodenal mucosa. Delayed gastric emptying was more common in functional dyspepsia and chromogranin-A was expressed more in pancreatic fibrosis. In conclusion, pancreatic fibrosis (including early chronic pancreatitis) outnumbered peptic ulcer disease in the dyspeptic population and pancreatic enzyme therapy was effective for 82% of cases. In early chronic pancreatitis, pancreatic fibrosis is dominant in the head location, and duodenum mucosa chromogranin-A is a potential biomarker with increased expression in an age-matched manner.

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“…На сьогоднішній день ерадикація інфекції Helicobacter pylori є основним патогенетичним лікуванням ВХ та хронічного артрофічного гастриту [5]. Міжнародно визнані підходи до діагностики та засади фармакотерапії ВХ оновлюються кожні 5 років, що знаходить своє відображення у положеннях Маастрихтського консенсусу (Маастрихт-І (1996 р.…”

Section: тетрахлорметановий гепатит з фоновим етанол-індукованим циро...unclassified

“…), Маастрихт-V (2022 р.)). Сучасні схеми антихелікобактерної терапії містять препарати вісмуту, інгібітори протонної помпи (ІПП) та комбінацію 2-3 антибактеріальних препаратів з переліку: амоксицилін, кларитроміцин, метронідазол, тетрациклін, левофлоксацин, рифабутин або фуразолідон [3,4,5]. Така варіативність схем лікування хелікобактеріозу обґрунтована прогресуючою антибіотикорезистентністю Helicobacter pylori, особливо до кларитроміцину та метронідазолу [4,5].…”

Section: тетрахлорметановий гепатит з фоновим етанол-індукованим циро...unclassified

Gender determinism of the effect of placenta cryoextract on the hepatotropic effects of esomeprazole, clarithromycin and metronidazole in chronic liver damage

Chyzh

Кошурба

Марченко

et al. 2023

Modern Medical Technology

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Current regimens for the eradication of Helicobacter pylori infection include bismuth drugs, proton pump inhibitors, and a combination of 2–3 antibacterial drugs. Uncontrolled use of antibacterial agents as part of eradication schemes increases the risk of developing their unwanted drug reactions, in particular, hepatotoxicity. As a means with potentially hepatoprotective activity, our attention was drawn to placental cryoextract. The purpose of the study. To characterize the gender aspects of the hepatotropic action of placenta cryoextract in tetrachloromethane hepatitis with background ethanol-induced cirrhosis and liver damage by antiulcer agents. Materials and methods. Research was conducted on 112 male and female rats. Tetrachloromethane hepatitis with background ethanol-induced liver cirrhosis was reproduced by injecting an oil solution of CCl4 in combination with a 5.0% ethanol solution for 45 days. Modulation of the content of sex hormones was achieved by surgical ovariectomy or testectomy. Results and discussion. Administration of esomeprazole, clarithromycin, and metronidazole in chronic liver damage in animals without changes in hormonal status led to a statistically significant (p=0.01) 27.6% increase in the level of bilirubin in homogenates of liver tissues in female rats (78.7±4.5 mmol/l) than in males. The greatest decrease in the content of bilirubin (41.7%, p<0.001) with the use of cryoextract of the placenta was noted in castrated female rats with simulated tetrachlormethone hepatitis with background ethanol-induced cirrhosis of the liver, which were injected with antiulcer agents. Conclusions. Administration of cryoextract of the placenta has a pronounced hepatoprotective effect in animals of both sexes. In male rats with no change in hormonal status with simulated liver injury and the administration of antiulcer drugs, placenta cryoextract therapy was more effective than in female rats, as indicated by a more than 1.6-fold decrease in the content of bilirubin in the liver homogenates of male rats (43.1%, p<0.001) than in females (27.4%, p<0.01).

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Helicobacter pylori : quand rechercher une infection et la traiter chez l’adulte ?

Cited by 4 publications

References 30 publications

Study of prognostic factors in gastric cancer: Application of a cox model and logistic regression

Study of prognostic factors in gastric cancer: Application of a cox model and logistic regression

Pancreatic Fibrosis (Early Chronic Pancreatitis) as Emerging Diagnosis in Structural Causes of Dyspepsia: Evidence from Endoscopic Ultrasonography and Shear Wave Elastography

Gender determinism of the effect of placenta cryoextract on the hepatotropic effects of esomeprazole, clarithromycin and metronidazole in chronic liver damage

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